Scintigraphical evaluation of alveolar clearance in horses.
Abstract: This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min-1) from lung into blood of nebulized 99mTc-DTPA has been established for healthy horses (Group A) compared with values obtained with horses suffering from chronic obstructive pulmonary disease (COPD; Group B). The 99mTc-DTPA clearance was measured in the caudoventral (R1) and in the half caudal (R2) parts of the left lung during different time intervals. The two regions aimed to define the influence of the airways on measured clearance (R2 contained proportionally more conducting airways than R1). It was concluded that a comparison of groups of subjects may be performed in R2 and on data collected during a 20 min period. The normal clearance rate in R2 was 1.80 +/- 0.46%.min-1 (T1/2R2 = 40.99 +/- 12.45 min) in Group A. In Group B, a significantly faster 99mTc-DTPA transfer rate was found (4.17 +/- 0.83%.min-1 or T1/2R2 = 17.17 +/- 3.38min). Bronchoalveolar lavage (BAL) suggested that the increased permeability measured in Group B could be the result of lung inflammatory responses. Our results have demonstrated the ability of the 99mTc-DTPA clearance test to detect alveolar epithelial damage in horses. Furthermore, we were able to show that a regional analysis of the alveolar-capillary barrier integrity may be performed satisfactorily in the equine patient.
Publication Date: 1998-08-06 PubMed ID: 9691851DOI: 10.1016/s1090-0233(98)80061-0Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Animal Health
- Bronchoalveolar Lavage
- Chronic Obstructive Pulmonary Disease
- Clinical Pathology
- Clinical Study
- Comparative Study
- Diagnosis
- Diagnostic Technique
- Disease Diagnosis
- Equine Diseases
- Equine Health
- Horses
- In Vivo
- Inflammation
- Lung Health
- Physiology
- Pulmonary Health
- Respiratory Health
- Scintigraphy
- Veterinary Medicine
Summary
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This research devised a standardized method to measure the permeability of the alveolar epithelium membrane in horses with the goal of determining normal rates and comparing them with those in horses afflicted with chronic obstructive pulmonary disease (COPD). The findings indicated an ability to assess alveolar epithelial damage in horses, with potential for regional examination of the alveolar-capillary barrier integrity.
Study Purpose and Method
- The purpose of this research was to develop a standard method to assess the permeability of the alveolar epithelial membrane in horses. This was done by establishing the typical rate of clearance of nebulized 99mTc-DTPA from the lung into the blood in healthy horses (Group A). This was then compared with the clearance rates in horses suffering from COPD (Group B).
- The 99mTc-DTPA clearance was measured in two different parts of the left lung during various time intervals. The purpose was to determine how the presence of airways influenced the clearance measurement, as one region contained more conducting airways than the other.
Results
- The study proposed that a comparison of the subject groups could be done based on data collected over 20 minutes from the region with a higher number of airways.
- The normal clearance rate in this region was 1.80 +/- 0.46%.min-1 (T1/2R2 = 40.99 +/- 12.45 min) in Group A (healthy horses).
- For Group B (COPD horses), a significantly higher 99mTc-DTPA transfer rate was found, suggesting that these horses had increased permeability of the alveolar epithelial membrane likely due to inflammatory responses in the lung, based on bronchoalveolar lavage (BAL) indications.
Conclusion
- The results demonstrated the capability of the 99mTc-DTPA clearance test to detect damage to the alveolar epithelial in horses.
- Moreover, the study suggested the feasibility of performing a regional examination of the alveolar-capillary barrier integrity in equine patients, providing valuable insights into lung diseases such as COPD in horses.
Cite This Article
APA
Votion D, Vandenput S, Duvivier DH, Lambert P, Art T, Lekeux P.
(1998).
Scintigraphical evaluation of alveolar clearance in horses.
Vet J, 156(1), 51-58.
https://doi.org/10.1016/s1090-0233(98)80061-0 Publication
Researcher Affiliations
- Department of Physiology, Faculty of Veterinary Medicine, University of Liège, Belgium.
MeSH Terms
- Animals
- Horses / physiology
- Lung Diseases / diagnostic imaging
- Lung Diseases / veterinary
- Pulmonary Alveoli / diagnostic imaging
- Pulmonary Alveoli / physiology
- Radionuclide Imaging
- Respiratory Function Tests / veterinary
- Technetium Tc 99m Pentetate
Citations
This article has been cited 2 times.- de Wasseige S, Picotte K, Lavoie JP. Nebulized dexamethasone sodium phosphate in the treatment of horses with severe asthma. J Vet Intern Med 2021 May;35(3):1604-1611.
- Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Can J Vet Res 2014 Jul;78(3):214-20.
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