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Home / Equine Research Bank / Animals (Basel) / Screening the Presence of Non-Typhoidal Salmonella in Differ...
Animals : an open access journal from MDPI2021; 11(6); doi: 10.3390/ani11061532

Screening the Presence of Non-Typhoidal Salmonella in Different Animal Systems and the Assessment of Antimicrobial Resistance.

Abstract: Salmonella is a major bacterial foodborne pathogen that causes the majority of worldwide food-related outbreaks and hospitalizations. Salmonellosis outbreaks can be caused by multidrug-resistant (MDR) strains, emphasizing the importance of maintaining public health and safer food production. Nevertheless, the drivers of MDR Salmonella serovars have remained poorly understood. In this study, we compare the resistance profiles of Salmonella strains isolated from 4047 samples from domestic and wild animals in Chile. A total of 106 Salmonella strains (2.61%) are isolated, and their serogroups are characterized and tested for susceptibility to 16 different antimicrobials. The association between antimicrobial resistance (AMR) and a subset of independent variables is evaluated using multivariate logistic models. Our results show that 47 antimicrobial-resistant strains were found (44.3% of the total strains). Of the 47, 28 correspond to single-drug resistance (SDR = 26.4%) and 19 are MDR (17.9%). S. Enteritidis is highly persistent in animal production systems; however, we report that serogroup D strains are 18 times less likely to be resistant to at least one antimicrobial agent than the most common serogroup (serogroup B). The antimicrobials presenting the greatest contributions to AMR are ampicillin, streptomycin and tetracycline. Additionally, equines and industrial swine are more likely to acquire Salmonella strains with AMR. This study reports antimicrobial-susceptible and resistant Salmonella in Chile by expanding the extant literature on the potential variables affecting antimicrobial-resistant Salmonella.
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Publication Date: 2021-05-24 PubMed ID: 34074040PubMed Central: PMC8225015DOI: 10.3390/ani11061532Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study looks into the resistance profiles of Non-typhoidal Salmonella strains found in animals in Chile, to gauge the prevalence of antimicrobial-resistant strains and the drivers behind such resistance.

Research Methodology and Findings

  • The researchers collected a total of 4047 samples from both domestic and wild animals. From these, they were able to isolate 106 Non-typhoidal Salmonella strains, which accounted for 2.61% of the total samples collected.
  • The resistance profiles of these strains were then assessed against 16 different antimicrobials, and their serogroups were characterized.
  • To evaluate the association between antimicrobial resistance (AMR) and various independent variables, the team used multivariate logistic models.
  • Results showed 47 strains to be antimicrobial-resistant, 44.3% of the total strains, with 28 strains resistant to a single drug (26.4%) and 19 strains multiresistant (17.9%).

Serogroup Specific Resistance

  • The study found that while the serogroup Enteritidis is highly persistent in animal production systems, serogroup D strains were 18 times less likely to be resistant to at least one antimicrobial agent compared to the most common serogroup (serogroup B).
  • This highlights the possible different natural or selective pressures faced by the different serogroups in the animal systems, influencing their resistance or susceptibility to antimicrobials.

Major Contributors to Antimicrobial resistance (AMR)

  • From the analysis, the most notable contributors to AMR amongst the tested agents were identified to be ampicillin, streptomycin, and tetracycline.

Host Factors in Antimicrobial Resistance (AMR)

  • Significantly, the study also found that horses and industrial pigs were more likely to carry antimicrobial-resistant Salmonella strains.
  • This finding suggests that host factors and environments may be contributing to the increased risk of AMR occurrence.

Significance of the study

  • This research provides new insights into the prevalence and drivers of antimicrobial-resistant Salmonella in animals in Chile, contributing to the existing literature on ways to mitigate the growth and spread of antimicrobial-resistant Salmonella.

Cite This Article

APA
Rivera D, Allel K, Dueñas F, Tardone R, Soza P, Hamilton-West C, Moreno-Switt AI. (2021). Screening the Presence of Non-Typhoidal Salmonella in Different Animal Systems and the Assessment of Antimicrobial Resistance. Animals (Basel), 11(6). https://doi.org/10.3390/ani11061532

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 6

Researcher Affiliations

Rivera, Dácil
  • Facultad de Ciencias de la Vida, Universidad Andres Bello, Republica 440, Santiago 8320000, Chile.
  • Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago 7550000, Chile.
Allel, Kasim
  • Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago 7550000, Chile.
  • Department of Disease Control, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
  • Antimicrobial Resistance Centre, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Dueñas, Fernando
  • Facultad de Ciencias de la Vida, Universidad Andres Bello, Republica 440, Santiago 8320000, Chile.
Tardone, Rodolfo
  • Facultad de Ciencias de la Vida, Universidad Andres Bello, Republica 440, Santiago 8320000, Chile.
Soza, Paula
  • Facultad de Ciencias de la Vida, Universidad Andres Bello, Republica 440, Santiago 8320000, Chile.
Hamilton-West, Christopher
  • Departamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santa Rosa 11735, La Pintana, Santiago 8820000, Chile.
Moreno-Switt, Andrea I
  • Facultad de Ciencias de la Vida, Universidad Andres Bello, Republica 440, Santiago 8320000, Chile.
  • Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago 7550000, Chile.
  • Escuela de Medicina Veterinaria, Pontificia Universidad Católica de Chile, Santiago 7810000, Chile.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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