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British journal of anaesthesia1987; 59(8); 1027-1034; doi: 10.1093/bja/59.8.1027

Selective mechanical ventilation of dependent lung regions in the anaesthetized horse in dorsal recumbency.

Abstract: The effect of selective mechanical ventilation of dependent lung regions were studied in anaesthetized horses (mean weight 486 kg) in dorsal recumbency. Blood-gas measurements were performed with the horse in the lateral position during spontaneous breathing (before selective intubation) and in dorsal recumbency during spontaneous breathing, general mechanical ventilation, and spontaneous breathing + selective mechanical ventilation. Arterial oxygen tension (PaO2) was 32.3 kPa in the lateral position during spontaneous breathing with a high inspired oxygen fraction (FlO2 greater than 92%). In dorsal recumbency PaO2 decreased to 10.9 kPa during spontaneous breathing and was not significantly affected by general mechanical ventilation (PaO2 12.6 kPa). The institution of selective mechanical ventilation with a selective positive end-expiratory pressure (PEEP) of 20 cm H2O caused a marked increase in PaO2 to an average of 35.3 kPa. It is concluded that selective intubation of dependent regions in the diaphragmatic lobes is a feasible procedure and that selective mechanical ventilation with PEEP markedly improves arterial oxygenation in the anaesthetized horse in dorsal recumbency.
Publication Date: 1987-08-01 PubMed ID: 3307855DOI: 10.1093/bja/59.8.1027Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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This research explores the impact of selectively ventilating dependent lung regions in anaesthetized horses lying on their backs. The results suggest that this technique markedly enhances oxygen saturation in the blood, making the procedure a viable option for improving arterial oxygenation in such situations.

Introduction

  • Researchers investigated the effect of selective mechanical ventilation, specifically targeting dependent lung regions, in anaesthetized horses positioned on their backs, or in dorsal recumbency.
  • The study seeks to determine whether selectively ventilating dependent regions of the lungs can significantly improve oxygen delivery to the body during anesthesia.
  • This research is important for equine anesthesia techniques, especially in surgical procedures where horses need to be positioned supine.

Methodology

  • Large horses with an average weight of 486 kg were anaesthetized and monitored in the lateral and dorsal recumbency positions during different breathing conditions.
  • These conditions included spontaneous breathing, general mechanical ventilation, and a combination of spontaneous breathing and selective mechanical ventilation.
  • Blood-gas readings, with particular attention to arterial oxygen tension (PaO2), were obtained and analyzed during each phase of the experiment.

Results

  • When the horses were in lateral position and spontaneously breathing with a high fraction of inspired oxygen (over 92%), the average arterial oxygen tension (PaO2) stood at 32.3 kPa.
  • However, when the horses were repositioned on their backs, or in dorsal recumbency, the PaO2 dropped to 10.9 kPa during spontaneous breathing and 12.6 kPa under general mechanical ventilation.
  • Remarkably, when selective mechanical ventilation with an added positive end-expiratory pressure (PEEP) of 20 cm H2O was applied, the PaO2 significantly elevated to an average of 35.3 kPa, indicating improved oxygen saturation in the arterial blood of the anesthetized horses.

Conclusion

  • The study’s outcomes suggest that selective intubation of dependent regions in the diaphragmatic lobes can be a viable procedure.
  • It’s crucial to note that this technique significantly improves arterial oxygenation for horses under anesthesia laying on their backs.
  • This finding could have vital implications in improving oxygenation methods during equine surgical procedures and possibly reducing post-anesthesia complications related to hypoxia.

Cite This Article

APA
Nyman G, Frostell C, Hedenstierna G, Funkquist B, Kvart C, Blomqvist H. (1987). Selective mechanical ventilation of dependent lung regions in the anaesthetized horse in dorsal recumbency. Br J Anaesth, 59(8), 1027-1034. https://doi.org/10.1093/bja/59.8.1027

Publication

ISSN: 0007-0912
NlmUniqueID: 0372541
Country: England
Language: English
Volume: 59
Issue: 8
Pages: 1027-1034

Researcher Affiliations

Nyman, G
  • Department of Surgery, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Frostell, C
    Hedenstierna, G
      Funkquist, B
        Kvart, C
          Blomqvist, H

            MeSH Terms

            • Anesthesia, General / veterinary
            • Animals
            • Female
            • Horses / physiology
            • Lung / physiology
            • Male
            • Oxygen / blood
            • Positive-Pressure Respiration / veterinary
            • Posture
            • Pulmonary Gas Exchange
            • Respiration, Artificial / methods
            • Respiration, Artificial / veterinary

            Citations

            This article has been cited 5 times.
            1. Savvas I, Pavlidou K, Braun C, Schauvliege S, Staffieri F, Moens Y. Evaluation of the Effect of the Inspired Oxygen Fraction on Blood Oxygenation during Inhalant Anaesthesia in Horses: A Systematic Review with Meta-Analysis. Animals (Basel) 2021 Jul 30;11(8).
              doi: 10.3390/ani11082245pubmed: 34438703google scholar: lookup
            2. Ishizuka T, Tamura J, Nagaro T, Sudo K, Itami T, Umar MA, Miyoshi K, Sano T, Yamashita K. Effects of intermittent positive pressure ventilation on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA). J Vet Med Sci 2014 Dec;76(12):1577-82.
              doi: 10.1292/jvms.14-0077pubmed: 25649938google scholar: lookup
            3. Gregson R, Clutton RE. Near-fatal misuse of medical tape around an endotracheal tube connector during inhalation anesthesia in a horse. Can Vet J 2012 Sep;53(9):978-82.
              pubmed: 23450862
            4. Hubbell JA, Aarnes TK, Bednarski RM, Lerche P, Muir WW. Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses. BMC Vet Res 2011 Jun 3;7:23.
              doi: 10.1186/1746-6148-7-23pubmed: 21639886google scholar: lookup
            5. Otsuka T, Araki M, Mita H, Kambayashi Y, Yoshihara E, Ohta M. Total intravenous anesthesia with propofol-ketamine-xylazine with or without remifentanil in thoroughbred horses undergoing castration. J Equine Sci 2024 Oct;35(3):35-41.
              doi: 10.1294/jes.35.35pubmed: 39411213google scholar: lookup