Serial measurement of lactate concentration in horses with acute colitis.
Abstract: Serial measurement of lactate concentration is utilized for therapeutic and prognostic purposes in human critical care. The prognostic value of serial lactate measurement in equine acute colitis warrants investigation. Objective: Serial lactate concentrations are predictive of outcome in horses with colitis. Methods: A total of 101 horses with colitis. Methods: Retrospective study. Plasma L-lactate concentrations were measured at admission and at 4-8 and 24 hours after admission. Associations between admission, early (4-8 hours) and late (24 hours) lactate concentrations, and survival status were determined. The percent reduction in lactate concentration between admission and the early time point, and between admission and the late time point, was calculated. Using a cutoff value, associations between percent reduction in lactate and survival status and associations between percent reduction in lactate and clinical and clinicopathologic data were determined. Results: There was no association between admission plasma lactate concentration and survival status (P = .26). The 4-8 and 24 hour after admission lactate concentrations were associated with survival status (P = .023, .013, respectively). Lactate cutoffs of ≤2.3 and ≤1.5 mmol/L had the maximum sensitivity and specificity for predicting survival at the 4-8 and 24 hour time points, respectively. When lactate reduction ≥30% at 4-8 hours and ≥50% at 24 hours after admission were used as the cutoffs, the percent reduction of lactate concentration was significantly associated with survival (P = .012 and .019, respectively). Conclusions: The prognostic ability of serial measurement of blood lactate concentration warrants prospective study as a measure of therapeutic response in horses with colitis.
Copyright © 2011 by the American College of Veterinary Internal Medicine.
Publication Date: 2011-10-07 PubMed ID: 22092636DOI: 10.1111/j.1939-1676.2011.00808.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research examined the use of sequential lactate measurements as a potential prognostic tool in horses with acute colitis, finding a significant association between survival prognosis and lactate concentration levels after admission at specified time points.
Objective and Methodology of the Research
- The core objective of the study was to establish whether serial lactate concentrations could predict outcomes in horses with colitis. In order to accomplish this, the researchers analyzed retrospectively existing data from 101 horses diagnosed with colitis.
- The researchers measured Plasma L-lactate concentrations at various points; on admission, after 4-8 hours, and 24 hours post- admission. They then established the relationships between lactate levels at these times, the percentage decrease in lactate level from the time of admission to each of the subsequent time points, and the survival status of the horses.
Results of the Research
- The study discovered no association between initial plasma lactate levels at the time of admission and survival rate of the horses.
- However, the lactate levels measured around 4-8 hours and 24 hours after admission had a significant correlation with survival rates confirmed by statistical significance (P = .023 and .013, respectively).
- The researchers determined the most sensitive and accurate lactate level cutoffs for predicting survival at the 4-8 and 24-hour marks. These were ≤2.3 and ≤1.5 mmol/L, respectively.
- The study also discovered that a lactate reduction of at least 30% after 4-8 hours and a minimum of 50% after 24 hours from admission could be linked meaningfully with horse survival, confirmed by statistical significance (P = .012 and .019, respectively).
Conclusion
- The researchers concluded that the sequential measurement of blood lactate concentration has prognostic potential and warrants further prospective studies to determine its applicability as a measure of therapeutic response in horses suffering from colitis.
Cite This Article
APA
Hashimoto-Hill S, Magdesian KG, Kass PH.
(2011).
Serial measurement of lactate concentration in horses with acute colitis.
J Vet Intern Med, 25(6), 1414-1419.
https://doi.org/10.1111/j.1939-1676.2011.00808.x Publication
Researcher Affiliations
- William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA.
MeSH Terms
- Animals
- Colitis / blood
- Colitis / veterinary
- Horse Diseases / blood
- Horses
- Lactates / blood
- Retrospective Studies
- Time Factors
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