Serum concentrations of keratan sulfate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to standardbred horses during race training.
Abstract: To determine the effects of orally administered glucosamine on concentrations of markers of bone and cartilage metabolism in Standardbred horses during race training. Methods: Twenty 16- to 20-month-old Standardbreds beginning race training. Methods: Horses were randomly assigned to 2 groups. One group received glucosamine hydrochloride (4 g, PO, q 12 h), and the second (control) group received glucose (4 g, PO, q 12 h). Serum samples were obtained prior to onset of the study (baseline) and at regular intervals for 48 weeks for determination of concentrations of keratan sulfate (KS), osteocalcin (OC), and pyridinoline crosslinks (PYD). Results: Osteocalcin concentrations changed significantly with time; mean serum concentrations were significantly higher than baseline values for samples obtained at 24 to 48 weeks after onset of the study. Although a significant effect of time was observed for mean concentration of KS, concentrations did not differ significantly from baseline values at any time during the study when groups were analyzed separately. However, pooled analysis revealed significant increases of mean serum KS concentration at weeks 24 and 30. Significant changes in serum PYD concentrations were not detected. Oral administration of glucosamine did not significantly affect serum concentrations of any of the markers. Conclusions: Increased serum OC in clinically normal Standardbreds during race training may reflect bone formation that accompanies adaptive remodeling of the appendicular skeleton. For these experimental conditions, glucosamine did not appear to exert a detectable influence on serum concentrations of these 3 markers of connective tissue metabolism.
Publication Date: 2002-08-13 PubMed ID: 12171162DOI: 10.2460/ajvr.2002.63.1106Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article examines the impact of orally administered glucosamine on bone and cartilage metabolism in Standardbred horses during race training. It concludes that although there were changes in some markers over time, glucosamine didn’t have a significant impact on these changes.
Objective and Methods
- The research aimed to study how oral glucosamine affects concentrations of markers of bone and cartilage metabolism in Standardbred horses during race training.
- Twenty horses aged between 16 and 20 months, about to start race training, were randomly divided into two groups. One group was given glucosamine hydrochloride, and the control group was given glucose.
- Serum samples were collected at the start of the study and at regular intervals for 48 weeks to determine the concentrations of keratan sulfate (KS), osteocalcin (OC), and pyridinoline crosslinks (PYD) – key markers of connective tissue metabolism.
Results
- Osteocalcin concentrations changed significantly over time, with mean serum concentrations being noticeably higher than initial values for samples taken 24 to 48 weeks after the study began.
- There was also a significant effect of time on the mean concentration of KS, but the concentrations didn’t significantly differ from the initial values at any time during the study when the groups were analyzed separately.
- Pooled analysis revealed significant increases in mean serum KS concentration at weeks 24 and 30.
- No notable changes in serum PYD concentrations were found.
- The oral administration of glucosamine did not significantly affect the serum concentrations of any of the markers.
Conclusions
- The increase in serum OC during race training in healthy Standardbreds may be an indication of bone formation that accompanies the adaptive remodeling of the appendicular skeleton.
- Under these experimental conditions, glucosamine did not appear to have a considerable effect on serum concentrations of these three markers of connective tissue metabolism.
Cite This Article
APA
Caron JP, Peters TL, Hauptman JG, Eberhart SW, Orth MW.
(2002).
Serum concentrations of keratan sulfate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to standardbred horses during race training.
Am J Vet Res, 63(8), 1106-1110.
https://doi.org/10.2460/ajvr.2002.63.1106 Publication
Researcher Affiliations
- Departments of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA.
MeSH Terms
- Administration, Oral
- Amino Acids / blood
- Animals
- Bone and Bones / metabolism
- Cartilage / metabolism
- Collagen / blood
- Glucosamine / pharmacology
- Horses / blood
- Horses / metabolism
- Horses / physiology
- Keratan Sulfate / blood
- Osteocalcin / blood
- Physical Conditioning, Animal / physiology
- Random Allocation
Citations
This article has been cited 1 times.- Matheson A, Regmi SC, Jay GD, Schmidt TA, Scott WM. The Effect of Intense Exercise on Equine Serum Proteoglycan-4/Lubricin. Front Vet Sci 2020;7:599287.
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