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Home / Equine Research Bank / J Vet Intern Med / Serum cortisol and thyroid hormone concentrations and surviv...
Journal of veterinary internal medicine2020; 34(3); 1332-1338; doi: 10.1111/jvim.15758

Serum cortisol and thyroid hormone concentrations and survival in foals born from mares with experimentally induced ascending placentitis.

Abstract: There are few publications on occurrence of nonthyroidal illness syndrome in foals and on the prognostic value of cortisol and thyroid hormone (TH) concentrations in newborn foals. Objective: To determine serum cortisol and TH concentrations (total and free thyroxine: T and T ; total and free triiodothyronine: T and T ) in foals born from mares with placentitis, to determine their association with survival, and their use as prognostic markers. Methods: A cohort of 29 newborn foals comprising 5 Control, 14 Low-risk, and 10 Sick foals were evaluated over the first week of life. Methods: In this prospective study foals born to mares with experimentally-induced placentitis were assigned to Low-risk or Sick groups while foals born to control mares were classified as Control based on clinical findings. Foals were also classified as Term (n = 13), Dysmature (n = 7), or Premature (n = 9), and survival rate was recorded. Serum cortisol and TH hormone concentrations were measured at 0, 12, 24, 48, and 168 hours of life. Results: Sick non-surviving foals had lower (P < .05) T : cortisol ratio at 12 (3.68 ± 1.06 versus 18.58 ± 2.78), 24 (5.47 ± 2.34 versus 23.40 ± 3.82), and 48 (10.47 ± 6.29 versus 26.6 ± 2.90) hours of life when compared to Sick surviving foals and lower (P < .05) T : cortisol ratio at 12 (75.12 ± 21.71 versus 414.47 ± 58.47) and 24 hours (127.83 ± 55.21 versus 430.87 ± 80.31) after birth than Sick surviving foals. Conclusions: Placental infections can impair fetal thyroid function. Low T : cortisol and T : cortisol ratios seem to be good prognostic markers in newborn foals.
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2020-04-27 PubMed ID: 32339347PubMed Central: PMC7255665DOI: 10.1111/jvim.15758Google Scholar: Lookup
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Summary

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The research paper focuses on the concentration of cortisol and thyroid hormone in newborn foals born from mares with placentitis. It looks into how these levels influence the survival rates of the foals, as well as the potential for such levels to be used as prognostic markers.

Research Objective and Methods

  • The primary objective of the study was to determine the serum cortisol and thyroid hormone (both total and free thyroxine and triiodothyronine) concentrations in newborn foals derived from mares suffering from placentitis, and their correlation with the foals’ survival.
  • The study involved a group of 29 newborn foals, which included 5 Control foals (from healthy mares), 14 Low-risk foals, and 10 Sick foals (from mares with placentitis). The classification of Low-risk and Sick was based on clinical findings.
  • Foals were further categorized as Term, Dysmature, or Premature. The researchers also recorded survival rates of the foals.
  • The measurement of serum cortisol and thyroid hormone concentrations took place at specific hours after birth: 0, 12, 24, 48, and 168 hours.

Research Findings

  • According to the study, Sick non-surviving foals exhibited lower ratios of thyroxine to cortisol at 12, 24, and 48 hours after birth, compared to Sick surviving foals.
  • The same Sick non-surviving foals also displayed a lower ratio of triiodothyronine to cortisol at 12 and 24 hours after birth than Sick surviving foals. This implies a correlation between these ratios and the survival of the foals.

Conclusions

  • The conclusions drawn from the study are two-fold. Firstly, placental infections in mares can potentially disrupt fetal thyroid function.
  • Secondly, low thyroxine to cortisol and triiodothyronine to cortisol ratios could act as reliable prognostic markers in newborn foals. These can help to predict the outcome for the foals born from mares with placentitis.

Cite This Article

APA
Müller V, Toribio RE, Dembek K, Moraes BSS, Mousquer MA, Curcio BR, Nogueira CEW. (2020). Serum cortisol and thyroid hormone concentrations and survival in foals born from mares with experimentally induced ascending placentitis. J Vet Intern Med, 34(3), 1332-1338. https://doi.org/10.1111/jvim.15758

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 34
Issue: 3
Pages: 1332-1338

Researcher Affiliations

Müller, Vitória
  • Departamento de Clínicas Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Toribio, Ramiro E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States.
Dembek, Katarzyna
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Iowa, United States.
Moraes, Bruna S S
  • Departamento de Clínicas Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Mousquer, Mariana A
  • Departamento de Clínicas Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Curcio, Bruna R
  • Departamento de Clínicas Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Nogueira, Carlos E W
  • Departamento de Clínicas Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.

MeSH Terms

  • Animals
  • Animals, Newborn
  • Female
  • Horse Diseases / blood
  • Horse Diseases / mortality
  • Horse Diseases / physiopathology
  • Horses
  • Hydrocortisone / blood
  • Placenta Diseases / microbiology
  • Placenta Diseases / veterinary
  • Pregnancy
  • Pregnancy Complications, Infectious / veterinary
  • Prospective Studies
  • Streptococcal Infections / veterinary
  • Streptococcus equi
  • Thyroid Hormones / blood
  • Thyroxine / blood
  • Triiodothyronine / blood

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 27 references
  1. Morresey PR. Prenatal and perinatal indicators of neonatal viability. Clin Tech Equine Pract 2005;4:238‐249.
    doi: 10.1053/j.ctep.2005.07.005google scholar: lookup
  2. Bain FT. Management of the foal from the mare with placentitis: a clinician's approach. 50th Annu. Conv. Am. Assoc. Equine Pract.; 2004; Denver.
  3. Rossdale PD, Ousey JC, Silver M, Fowden A. Studies on equine prematurity 6: Guidelines for assessment of foal maturity.. Equine Vet J 1984 Jul;16(4):300-2.
    pubmed: 6090120doi: 10.1111/j.2042-3306.1984.tb01931.xgoogle scholar: lookup
  4. Sanchez LC. Equine neonatal sepsis.. Vet Clin North Am Equine Pract 2005 Aug;21(2):273-93, v.
    doi: 10.1016/j.cveq.2005.04.007pubmed: 16051050google scholar: lookup
  5. Farwell AP. Nonthyroidal illness syndrome.. Curr Opin Endocrinol Diabetes Obes 2013 Oct;20(5):478-84.
    doi: 10.1097/01.med.0000433069.09294.e8pubmed: 23974778google scholar: lookup
  6. Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB. Nonthyroidal illnesses syndrome in full-term newborns with sepsis.. Arch Endocrinol Metab 2015 Dec;59(6):528-34.
    doi: 10.1590/2359-3997000000111pubmed: 26677087google scholar: lookup
  7. Laurberg P. Mechanisms governing the relative proportions of thyroxine and 3,5,3'-triiodothyronine in thyroid secretion.. Metabolism 1984 Apr;33(4):379-92.
    pubmed: 6369072doi: 10.1016/0026-0495(84)90203-8google scholar: lookup
  8. Irvine CH. Hypothyroidism in the foal.. Equine Vet J 1984 Jul;16(4):302-6.
    doi: 10.1111/j.2042-3306.1984.tb01932.xpubmed: 6383812google scholar: lookup
  9. Toribio RE. Endocrine dysregulation in critically ill foals and horses.. Vet Clin North Am Equine Pract 2011 Apr;27(1):35-47.
    doi: 10.1016/j.cveq.2010.12.011pubmed: 21392652google scholar: lookup
  10. Silver M, Fowden AL, Knox J, Ousey J, Cash R, Rossdale PD. Relationship between circulating tri-iodothyronine and cortisol in the perinatal period in the foal.. J Reprod Fertil Suppl 1991;44:619-26.
    pubmed: 1665521
  11. Fowden AL, Forhead AJ, Ousey JC. Endocrine adaptations in the foal over the perinatal period.. Equine Vet J Suppl 2012 Feb;(41):130-9.
    doi: 10.1111/j.2042-3306.2011.00505.xpubmed: 22594041google scholar: lookup
  12. Samuels MH, McDaniel PA. Thyrotropin levels during hydrocortisone infusions that mimic fasting-induced cortisol elevations: a clinical research center study.. J Clin Endocrinol Metab 1997 Nov;82(11):3700-4.
    pubmed: 9360528doi: 10.1210/jcem.82.11.4376google scholar: lookup
  13. Johnson EO, Calogero AE, Konstandi M, Kamilaris TC, La Vignera S, Chrousos GP. Effects of short- and long-duration hypothyroidism on hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies.. Endocrine 2012 Dec;42(3):684-93.
    pubmed: 22695985doi: 10.1007/s12020-012-9714-zgoogle scholar: lookup
  14. Himler M, Hurcombe SD, Griffin A, Barsnick RJ, Rathgeber RA, MacGillivray KC, Toribio RE. Presumptive nonthyroidal illness syndrome in critically ill foals.. Equine Vet J Suppl 2012 Feb;(41):43-7.
    doi: 10.1111/j.2042-3306.2011.00480.xpubmed: 22594025google scholar: lookup
  15. Panzani S, Comin A, Galeati G, Romano G, Villani M, Faustini M, Veronesi MC. How type of parturition and health status influence hormonal and metabolic profiles in newborn foals.. Theriogenology 2012 Apr 1;77(6):1167-77.
    doi: 10.1016/j.theriogenology.2011.10.023pubmed: 22153270google scholar: lookup
  16. Pirrone A, Panzani S, Govoni N, Castagnetti C, Veronesi MC. Thyroid hormone concentrations in foals affected by perinatal asphyxia syndrome.. Theriogenology 2013 Oct 1;80(6):624-9.
    doi: 10.1016/j.theriogenology.2013.06.003pubmed: 23849257google scholar: lookup
  17. Breuhaus BA. Thyroid function and dysfunction in term and premature equine neonates.. J Vet Intern Med 2014 Jul-Aug;28(4):1301-9.
    doi: 10.1111/jvim.12382pmc: PMC4857961pubmed: 24934827google scholar: lookup
  18. Curcio BR, Canisso IF, Pazinato FM, Borba LA, Feijó LS, Muller V, Finger IS, Toribio RE, Nogueira CEW. Estradiol cypionate aided treatment for experimentally induced ascending placentitis in mares.. Theriogenology 2017 Oct 15;102:98-107.
    doi: 10.1016/j.theriogenology.2017.03.010pubmed: 28755579google scholar: lookup
  19. Bucca S, Fogarty U, Collins A, Small V. Assessment of feto-placental well-being in the mare from mid-gestation to term: transrectal and transabdominal ultrasonographic features.. Theriogenology 2005 Aug;64(3):542-57.
    pubmed: 15993936doi: 10.1016/j.theriogenology.2005.05.011google scholar: lookup
  20. Koterba AM, Drummond WH, Kosch PC. Equine Clinical Neonatology. 1st ed. Philadelphia, Pennsylvania: Lea & Febiger; 1990.
  21. Brewer BD, Koterba AM. Development of a scoring system for the early diagnosis of equine neonatal sepsis.. Equine Vet J 1988 Jan;20(1):18-22.
    doi: 10.1111/j.2042-3306.1988.tb01445.xpubmed: 3366100google scholar: lookup
  22. Lyle SK. The Relationship Between Pro‐inflammatory Cytokines, Prostaglandins, and Fetal Hypothalamic‐Pituitary‐Adrenal Axis Activation in Mares with Infective Pre‐term Delivery. Louisiana: Louisiana State University; 2008.
  23. LeBlanc MM, Giguère S, Lester GD, Brauer K, Paccamonti DL. Relationship between infection, inflammation and premature parturition in mares with experimentally induced placentitis.. Equine Vet J Suppl 2012 Feb;(41):8-14.
    doi: 10.1111/j.2042-3306.2011.00502.xpubmed: 22594019google scholar: lookup
  24. McKenzie HC III, Furr MO. Equine neonatal sepsis: the pathophysiology of severe inflammation and infection. Compend Contin Educ Pract Vet 2014;23:661‐672.
  25. Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.. Endocr Rev 2011 Oct;32(5):670-93.
    doi: 10.1210/er.2011-0007pubmed: 21791567google scholar: lookup
  26. Tominaga T, Yamashita S, Nagayama Y, Morita S, Yokoyama N, Izumi M, Nagataki S. Interleukin 6 inhibits human thyroid peroxidase gene expression.. Acta Endocrinol (Copenh) 1991 Mar;124(3):290-4.
    pubmed: 2011918doi: 10.1530/acta.0.1240290google scholar: lookup
  27. Tang KT, Braverman LE, DeVito WJ. Tumor necrosis factor-alpha and interferon-gamma modulate gene expression of type I 5'-deiodinase, thyroid peroxidase, and thyroglobulin in FRTL-5 rat thyroid cells.. Endocrinology 1995 Mar;136(3):881-8.
    pubmed: 7867596doi: 10.1210/endo.136.3.7867596google scholar: lookup

Citations

This article has been cited 1 times.
  1. Johnson K, Peterson J, Kopper J, Dembek K. The hypothalamic-pituitary-adrenal axis response to ovine corticotropin-releasing-hormone stimulation tests in healthy and hospitalized foals. J Vet Intern Med 2023 Jan;37(1):292-301.
    doi: 10.1111/jvim.16604pubmed: 36651191google scholar: lookup
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