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Equine veterinary journal2009; 41(2); 149-152; doi: 10.2746/042516408x371928

Short-term anaesthesia with xylazine, diazepam/ketamine for castration in horses under field conditions: use of intravenous lidocaine.

Abstract: Lidocaine single boluses and/or constant rate infusions are commonly administered intraoperatively during inhalant anaesthesia to lower inhalant concentrations, promote or maintain gastrointestinal motility, and potentially supplement analgesia. The benefits of using lidocaine with injectable anaesthesia for field surgeries has not been fully explored to determine advantages and disadvantages of lidocaine as an anaesthetic and analgesic adjunct in these conditions and impact on recovery quality. Objective: To evaluate the use of systemic lidocaine with a standard field injectable anaesthetic protocol related to the need for additional drug administration as well as overall recovery score and quality. Objective: The administration of systemic lidocaine with xylazine-diazepam/ketamine anaesthesia for castration in the field decreases the need for additional injectable doses required for maintenance, but prolong and potentially impact the overall recovery score and quality in horses. Methods: Thirty client-owned horses underwent standard injectable anaesthesia for field castration. Fifteen horses received lidocaine 3 mg/kg bwt, i.v. as a single bolus, and 15 received saline equal volume. The horses were monitored for the need for additional injectable anaesthetics and scored for overall recovery and quality by a blinded anaesthetist. Results: There were no statistically significant differences in the overall recovery score and quality, or need for additional injectable anaesthetic between horses receiving lidocaine and those receiving saline. There was a significantly longer time for the horses to stand after induction in the lidocaine group (mean 30.7 min) vs. saline group (mean 22.5 min) (P<0.04). Conclusions: Lidocaine, 3 mg/kg bwt i.v., does not adversely affect recovery using injectable field regimes, but the overall recovery period was longer. Lidocaine does not appear to reduce the need for additional injectable administration during surgery. Conclusions: Further research is warranted to define the benefit of systemic lidocaine with field anaesthesia in horses by exploring the ideal dose and plasma level of lidocaine with injectable anaesthesia.
Publication Date: 2009-05-08 PubMed ID: 19418743DOI: 10.2746/042516408x371928Google Scholar: Lookup
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  • Journal Article

Summary

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This study aims to determine the effects of using lidocaine as an adjunct with xylazine-diazepam/ketamine anesthesia for horse castration in field conditions. The findings suggest that while lidocaine does not impact recovery negatively, it does not lower the need for additional injectable anesthetics and prolongs the overall recovery period.

Objective of the Study

  • The researchers sought to examine the impact of systemic lidocaine on the administration of xylazine-diazepam/ketamine anaesthesia for castration in horses, particularly in field settings. The study was primarily concerned with whether this combination would decrease the need for additional injections to maintain the effect, and how the addition of lidocaine would influence the recovery process and outcome.

Methodology

  • The study involved 30 client-owned horses, all undergoing castration under field conditions with standard injectable anesthesia. Among them, 15 received a single bolus of lidocaine at 3 mg/kg body weight intravenously, while the other 15 received an equivalent volume of saline.
  • The horses were monitored to assess their requirement for additional anesthetics during the procedure. Their recovery, both in terms of score and quality, was evaluated by an anaesthetist who was not privy to the specifics of each horse’s treatment (blinded).

Results and Findings

  • The study found no statistically significant difference in the recovery score and quality, or the requirement for additional anesthetics, between the lidocaine and saline groups. However, horses treated with lidocaine took a notably longer time to stand after induction: 30.7 minutes on average, versus 22.5 minutes in the saline group. This difference was statistically significant.

Conclusions and Implications

  • The study concluded that adding lidocaine to injectable anesthesia in field conditions does not adversely affect recovery, although it does extend the overall recovery period. Lidocaine may not be an effective means of reducing the need for supplementary anesthetic administrations.
  • Based on these results, the researchers recommended further exploration of the utility of systemic lidocaine in field anesthesia for horses. They suggested that future studies should aim to ascertain the most advantageous dose and plasma level when pairing lidocaine with injectable anesthesia.

Cite This Article

APA
Sinclair M, Valverde A. (2009). Short-term anaesthesia with xylazine, diazepam/ketamine for castration in horses under field conditions: use of intravenous lidocaine. Equine Vet J, 41(2), 149-152. https://doi.org/10.2746/042516408x371928

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 41
Issue: 2
Pages: 149-152

Researcher Affiliations

Sinclair, M
  • Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Valverde, A

    MeSH Terms

    • Anesthesia Recovery Period
    • Anesthesia, General / methods
    • Anesthesia, General / veterinary
    • Anesthetics, Inhalation / administration & dosage
    • Anesthetics, Local / administration & dosage
    • Anesthetics, Local / blood
    • Animals
    • Diazepam / administration & dosage
    • Dose-Response Relationship, Drug
    • Horses / physiology
    • Horses / surgery
    • Infusions, Intravenous / veterinary
    • Intraoperative Care / methods
    • Intraoperative Care / veterinary
    • Ketamine / administration & dosage
    • Lidocaine / administration & dosage
    • Lidocaine / blood
    • Male
    • Orchiectomy / methods
    • Orchiectomy / veterinary
    • Pain, Postoperative / veterinary
    • Random Allocation
    • Time Factors
    • Xylazine / administration & dosage

    Citations

    This article has been cited 2 times.
    1. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
      doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
    2. Robinson BL, Dumas M, Ali SF, Paule MG, Gu Q, Kanungo J. Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug-drug interaction. J Appl Toxicol 2017 Dec;37(12):1438-1447.
      doi: 10.1002/jat.3488pubmed: 28569378google scholar: lookup