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Agents and actions1978; 8(3); 191-198; doi: 10.1007/BF01966602

Spasmolytic action of histamine in airway smooth muscle of horse.

Abstract: Histamine, 2-methylhistamine (a specific H1-agonist), 5-HT, PGF2alpha, SRS-A, bradykinin (BK) and carbachol contract bronchial and tracheal smooth muscles of the horse. Isoprenaline, PGE1, E2, dimaprit and 4-methylhistamine (last two = specific H2-agonists) relaxed airways which were partially contracted to carbachol. Mepyramine (a specific H1-antagonist) selectively antagonized contractions to histamine. In the presence of mepyramine, histamine caused relaxation of airways partially contracted to carbachol. Metiamide and burimamide (specific H2-antagonists) specifically antagonized or reversed histamine-induced bronchorelaxation. However the H2-antagonists, indomethacin and propranolol each failed to block histamine-induced relaxations in trachea. Thus, the results of this study show: (i) preponderence of H1-receptors-mediating contractions in horse airways; (ii) presence of H2-receptors-mediating bronchorelaxation and (iii) the existence of an atypical (relaxant) response (resistance to H2-antagonists; indomethacin and propranolol) in the horse trachea.
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Publication Date: 1978-04-01 PubMed ID: 665431DOI: 10.1007/BF01966602Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the role of histamine and its specific agonists and antagonists in constricting and relaxing the smooth muscles in the bronchial and tracheal airways of horses. The findings reveal that H1-receptors mainly mediate muscle contractions, H2-receptors mediate muscle relaxation, and an unusual type of relaxation response occurs in a horse’s trachea that is resistant to traditional H2-antagonists.

Investigation on Histamine’s Impact on Horse Airways

  • The study used several chemical agents, including Histamine, 2-methylhistamine, 5-HT, PGF2alpha, SRS-A, bradykinin, and carbachol, to induce contractions in bronchial and tracheal smooth muscles of a horse.
  • Further, Isoprenaline, PGE1, E2, dimaprit and 4-methylhistamine, which are specific H2-agonists, were used to induce relaxation in partially contracted airways.

Role of H1 and H2 Receptors in Muscle Contractions

  • Mepyramine, a specific H1-antagonist, was found to selectively counteract or “antagonize” contractions caused by histamine, underscoring the preponderance of H1-receptors in mediating contractions.
  • When mepyramine was present, histamine was observed to relax the airways that were partially contracted, indicating the contradictory effect of histamine on muscle contraction and relaxation.

Relaxant Effects and Resistance to H2-Antagonists

  • The study also used H2-antagonists, metiamide and burimamide, which specifically antagonize or reverse the relaxation effects caused by histamine, indicating the role of H2-receptors in bronchorelaxation.
  • However, it was found that H2-antagonists, indomethacin, and propranolol, did not block histamine-induced relaxations in the horse’s trachea.
  • This points to an atypical relaxant response in horses which resists traditional H2-antagonists, indicating the complexities of histamine’s role and the existence of other unexplored mechanisms at work in the horses’ airway muscles.

Cite This Article

APA
Chand N, Eyre P. (1978). Spasmolytic action of histamine in airway smooth muscle of horse. Agents Actions, 8(3), 191-198. https://doi.org/10.1007/BF01966602

Publication

Agents and actions
ISSN: 0065-4299
NlmUniqueID: 0213341
Country: Switzerland
Language: English
Volume: 8
Issue: 3
Pages: 191-198

Researcher Affiliations

Chand, N
    Eyre, P

      MeSH Terms

      • Animals
      • Atropine / pharmacology
      • Bronchi / drug effects
      • Burimamide / pharmacology
      • Cimetidine / pharmacology
      • Histamine / pharmacology
      • Horses
      • In Vitro Techniques
      • Indomethacin / pharmacology
      • Metiamide / pharmacology
      • Muscle Contraction / drug effects
      • Muscle, Smooth / drug effects
      • Propranolol / pharmacology
      • Pyrilamine / pharmacology
      • Respiratory System / drug effects
      • Trachea / drug effects

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      Citations

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