Stem cells and regenerative medicine in domestic and companion animals: a multispecies perspective.
Abstract: Since their original isolation, the majority of the work on embryonic stem cells (ESC) has been carried out in mice. While the mouse is an outstanding model for basic research, it also has considerable limitations for translational work, especially in the area of regenerative medicine. This is due to a combination of factors that include physiological and size differences when compared to humans. In contrast, domestic animal species, such as swine, and companion animal species, such as dogs, provide unique opportunities to develop regenerative medicine protocols that can then be utilized in humans. Unfortunately, at present, the state of knowledge related to, and availability of, ESC from domestic animals vary among species such as pig, horse, dog and cat, and without exception lags significantly behind the mouse and human. It is clear that much still needs to be discovered. The 'stem cell-like' cell lines being reported are still not satisfactorily used in regenerative medicine, due to reasons such as heterogeneity and chromosomal instability. As a result, investigators have searched for alternate source of cells that can be used for regenerative medicine. This approach has uncovered a range of adult stem cells and adult progenitor cells that have utility in both human and veterinary medicine. Here, we review a range of stem cells, from ESC to induced pluripotent stem cells, and discuss their potential application in the field of regenerative medicine.
© 2014 Blackwell Verlag GmbH.
Publication Date: 2014-10-04 PubMed ID: 25277427DOI: 10.1111/rda.12392Google Scholar: Lookup
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- Journal Article
- Review
- Animal Health
- Animal Models
- Animal Science
- Animal Studies
- Biotechnology
- Cell Culture
- Cells
- Developmental Biology
- Domestic Animals
- Equine Diseases
- Equine Health
- Equine Medicine
- Equine Research
- Regenerative Medicine
- Species Comparison
- Stem Cells
- Veterinary Care
- Veterinary Medicine
- Veterinary Procedure
- Veterinary Research
Summary
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The study explores the use of stem cells from various domestic and companion animals for regenerative medicine, stating that while studies have widely used mice, animals like pigs and dogs may offer more beneficial comparisons to humans. Still, these animals’ stem cell understanding and availability are relatively lesser, and more research is needed to fully utilize them in regenerative medicine.
Study Overview
- This research primarily focuses on the applicability of embryonic stem cells (ESCs) from domestic and companion animals in regenerative medicine, as opposed to the traditional use of mouse ESCs.
- The authors emphasize the limitations of utilizing mouse ESCs for regenerative medicine due to significant physiological and size differences compared to humans.
Domestic and Companion Animal ESCs
- It proposes that domestic animals like swine and companion animals like dogs could provide more valuable insights for regenerative medicine geared towards human application, based on their more human-like physiology.
- However, the study acknowledges that these species’ ESCs understanding and availability are lacking and needs to be significantly enhanced.
Limitations of Current Stem Cell Varieties
- The authors detail some issues related to the ‘stem cell-like’ cell lines currently available, noting the limitations such as heterogeneity and chromosomal instability which make these cells unsatisfactory for use in regenerative medicine.
Alternative Cell Sources
- Due to the above-noted limitations, researchers are seeking alternative cell sources that can be used for regenerative medicine. This search has led to the discovery of a range of adult stem cells and adult progenitor cells.
- These cells are potentially useful in both human and veterinary medicine, expanding the applicability scope.
Potential Future Applications
- The study reviews various types of stem cells from embryonic to induced pluripotent stem cells with a focus on their potential future application in the ever-evolving field of regenerative medicine.
- The effort underlines a push towards more comprehensive, interspecies stem cell research which can broaden current understanding and further open the path to developing effective regenerative therapies.
Cite This Article
APA
Gonçalves NN, Ambrósio CE, Piedrahita JA.
(2014).
Stem cells and regenerative medicine in domestic and companion animals: a multispecies perspective.
Reprod Domest Anim, 49 Suppl 4, 2-10.
https://doi.org/10.1111/rda.12392 Publication
Researcher Affiliations
- Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, FZEA/USP, Pirassununga, Sao Paulo, Brazil; Department of Surgery, Faculty of Veterinary Medicine and Animal Science, FMVZ/USP, Sao Paulo, Brazil.
MeSH Terms
- Adult
- Animals
- Animals, Domestic / embryology
- Cats
- Dogs
- Embryonic Stem Cells
- Horses
- Humans
- Induced Pluripotent Stem Cells
- Mice
- Pets / embryology
- Rats
- Regenerative Medicine / trends
- Stem Cells
Citations
This article has been cited 11 times.- Huang J, Yang X, Wang J, Wu H, Pei D, Chen J. Fast and Efficient Mouse Pluripotency Reprogramming Using a Chemically-Defined Medium.. Methods Protoc 2022 Mar 24;5(2).
- Dias IE, Cardoso DF, Soares CS, Barros LC, Viegas CA, Carvalho PP, Dias IR. Clinical application of mesenchymal stem cells therapy in musculoskeletal injuries in dogs-a review of the scientific literature.. Open Vet J 2021 Apr-Jun;11(2):188-202.
- Polkoff K, Piedrahita JA. The transformational impact of site-specific DNA modifiers on biomedicine and agriculture.. Anim Reprod 2018 Aug 16;15(3):171-179.
- Kumar D, Talluri TR, Selokar NL, Hyder I, Kues WA. Perspectives of pluripotent stem cells in livestock.. World J Stem Cells 2021 Jan 26;13(1):1-29.
- Ambrósio CE, Orlandin JR, Oliveira VC, Motta LCB, Pinto PAF, Pereira VM, Padoveze LR, Karam RG, Pinheiro AO. Potential application of aminiotic stem cells in veterinary medicine.. Anim Reprod 2020 May 22;16(1):24-30.
- Casals JB, Pieri NCG, Roballo KCS, Bressan FF, Favaron PO, Martins DDS, Ambrósio CE. Pluripotent stem cells proliferation is associated with placentation in dogs.. Anim Reprod 2020 Aug 6;17(3):e20200040.
- Dias IE, Pinto PO, Barros LC, Viegas CA, Dias IR, Carvalho PP. Mesenchymal stem cells therapy in companion animals: useful for immune-mediated diseases?. BMC Vet Res 2019 Oct 22;15(1):358.
- Veron AD, Bienboire-Frosini C, Feron F, Codecasa E, Deveze A, Royer D, Watelet P, Asproni P, Sadelli K, Chabaud C, Stamegna JC, Fagot J, Khrestchatisky M, Cozzi A, Roman FS, Pageat P, Mengoli M, Girard SD. Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera.. BMC Vet Res 2018 Jan 17;14(1):17.
- Soto DA, Ross PJ. Pluripotent stem cells and livestock genetic engineering.. Transgenic Res 2016 Jun;25(3):289-306.
- Roberts RM, Yuan Y, Genovese N, Ezashi T. Livestock models for exploiting the promise of pluripotent stem cells.. ILAR J 2015;56(1):74-82.
- Kumar D, Talluri TR, Anand T, Kues WA. Induced pluripotent stem cells: Mechanisms, achievements and perspectives in farm animals.. World J Stem Cells 2015 Mar 26;7(2):315-28.
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