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Home / Equine Research Bank / Trends Biotechnol / Stem cells in veterinary medicine–attempts at regenera...
Trends in biotechnology2007; 25(9); 409-416; doi: 10.1016/j.tibtech.2007.07.009

Stem cells in veterinary medicine–attempts at regenerating equine tendon after injury.

Abstract: Stem cells have evoked considerable excitement in the animal-owning public because of the promise that stem cell technology could deliver tissue regeneration for injuries for which natural repair mechanisms do not deliver functional recovery and for which current therapeutic strategies have minimal effectiveness. This review focuses on the current use of stem cells within veterinary medicine, whose practitioners have used mesenchymal stem cells (MSCs), recovered from either bone marrow or adipose tissue, in clinical cases primarily to treat strain-induced tendon injury in the horse. The background on why this treatment has been advocated, the data supporting its use and the current encouraging outcome from clinical use in horses treated with bone-marrow-derived cells are presented together with the future challenges of stem-cell therapy for the veterinary community.
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Publication Date: 2007-08-09 PubMed ID: 17692415DOI: 10.1016/j.tibtech.2007.07.009Google Scholar: Lookup
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  • Non-U.S. Gov't
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the potential use of stem cells (specifically Mesenchymal Stem Cells) in veterinary medicine, by focusing on its application in regenerating equine tendon injuries, where current treatments are less effective and natural recovery is limited. It also reviews the supporting data, the promising results observed in clinical trials with horses, and future challenges for the expansion of stem-cell therapy in veterinary practice.

Background and Objective of the Study

  • The study aimed to explore the use of stem cells for tissue regeneration in veterinary medicine, targeting injuries that have inadequate natural repair mechanisms and where existing treatments show limited effectiveness. The research primarily focused on using stem cells for treating strain-induced tendon injuries in horses.

Type of Stem Cells Used and Their Origin

  • The practitioners in the study used Mesenchymal Stem Cells (MSCs) harvested from either bone marrow or adipose tissue. These types of stem cells have the potential to differentiate into different types of tissue cells, making them an excellent candidate for tissue regeneration work.

Reason for Advocacy and Supporting Data

  • The treatment with MSCs was promoted due to its potential for tissue regeneration, a valuable property considering that the natural recuperation processes and the existing therapies for these types of injuries have limited effectiveness. Support for their use in this context comes from data showing promising results in tissue regeneration and healing.

Clinical Outcome and Future Challenges

  • The use of bone-marrow-derived stem cells in treating tendon injuries in horses showed encouraging results from clinical use. However, the study also acknowledges the future challenges that need to be addressed for this therapy to be standardized in the veterinary community. These might include issues related to stem cell harvesting, bioethical concerns, and ensuring consistent, reproducible results across a range of different cases.

Cite This Article

APA
Richardson LE, Dudhia J, Clegg PD, Smith R. (2007). Stem cells in veterinary medicine–attempts at regenerating equine tendon after injury. Trends Biotechnol, 25(9), 409-416. https://doi.org/10.1016/j.tibtech.2007.07.009

Publication

Trends in biotechnology
ISSN: 0167-7799
NlmUniqueID: 8310903
Country: England
Language: English
Volume: 25
Issue: 9
Pages: 409-416

Researcher Affiliations

Richardson, Lucy E
  • Department of Veterinary Clinical Sciences, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Dudhia, Jayesh
    Clegg, Peter D
      Smith, Roger

        MeSH Terms

        • Animals
        • Horses / injuries
        • Mesenchymal Stem Cell Transplantation / veterinary
        • Mesenchymal Stem Cells / physiology
        • Tendon Injuries / physiopathology
        • Tendon Injuries / therapy
        • Tendon Injuries / veterinary
        • Tendons / anatomy & histology
        • Tendons / growth & development

        Citations

        This article has been cited 46 times.
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