Studies on some paraclinical indices on intoxication in horses from freshly cut Jimson weed (Datura stramonium)-contaminated maize intended for ensiling.

The paper explores the changes in certain blood parameter levels in 34 horses that consumed freshly harvested maize contaminated with young Datura stramonium plants. This research may aid in the diagnosis and prognosis of Jimson weed intoxication.

Objective of the Study

The primary goal of this study was to understand the impact of Jimson weed (Datura stramonium) contamination in maize on horses. By monitoring specific blood parameters over a period of 7 days in 34 horses that had ingested the contaminated maize, the researchers hoped to identify changes that could aid in detecting and treating such intoxication.

Monitored Blood Parameters

• The blood parameters that were closely observed during the study included haemoglobin content, red and white blood cell counts, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, differential white cell counts, erythrocyte sedimentation rate, protein fractions and several blood enzymes.
• The impact of the intoxication on these parameters was varied and substantial, thereby providing valuable information regarding how a horse’s body reacts to such a contamination.

Results of the Study

• The researchers noted significant changes in most of the blood parameters studied. Specifically, there was an observed increase in red blood cells (erythrocytosis), white blood cells (leukocytosis) and a regenerative left shift neutrophilia. Other notable changes include lymphopenia, eosinopenia, an elevated hematocrit value, and an increased amount of bilirubin in the blood (bilirubinemia).
• There were, however, some parameters that were not affected by the intoxication. These include mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, albumin, globulin, and globulin fractions.
• Blood parameters began to return to normal between the 2nd and 5th day post-intoxication.

Implications of the Study

• These findings are significant as they provide a tangible way of potentially diagnosing Jimson weed intoxication in horses by observing specific changes in blood parameters.
• The return to normal of most parameters within a few days also gives a time frame for monitoring and predicting the progress of recovery following intoxication.