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Immunology1971; 21(3); 443-454;

Studies on the IgA system of the horse.

Abstract: Equine serum and secretions were found to contain a protein which cross-reacted with an antiserum against human IgA, but not with antisera against any other human immunoglobulin. The physicochemical properties of equine IgA resembled those of human IgA. IgA was found to be the immunoglobulin having the highest secretion serum concentration ratio in equine lacteal and salivary secretions, and to be the protein produced by the majority of immunoglobulin-containing cells in the of the equine intestine.
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Publication Date: 1971-09-01 PubMed ID: 5568324PubMed Central: PMC1408142
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on a protein found in horse serum and secretions that overlaps with an antiserum against human IgA, an antibody subtype. This protein, identified as an antibody or IgA, showcases similarities with human IgA in its physical and chemical properties and appears as the most abundantly secreted in equine lacteal and salivary secretions.

Findings of IgA in Equine Serum and Secretions

  • The scientists discovered the presence of a particular protein in horse serum and secretions. This protein corresponded with an antiserum developed against human IgA, an antibody that plays a critical role in immune function. However, it did not exhibit a cross-reaction with antisera against other types of human immunoglobulins. This indicates that the protein is quite specific and could be a type of IgA in horses.

Physicochemical Properties of Equine IgA

  • Upon further analysis, the researchers noted that the equine (horse) IgA shares similar physical and chemical properties with human IgA. This similarity creates an important biological connection and can potentially provide insights into shared immune function mechanisms between species.

Role of IgA in Equine Secretions

  • IgA in horses was found to be the primary immunoglobulin in lacteal (milk) and salivary secretions. Its high secretion to serum concentration ratio indicates that this immunoglobulin has possibly an active role in these secretions, possibly providing a primary line of immune defense.

IgA Production in Equine Intestinal Cells

  • Finally, IgA was observed to be the primary protein produced by cells containing immunoglobulin in the horse’s intestinal region. This suggests a significant role of IgA in equine digestive health and immunity, as the intestine is a central site of interaction with potential pathogens.

Cite This Article

APA
Vaerman JP, Querinjean P, Heremans JF. (1971). Studies on the IgA system of the horse. Immunology, 21(3), 443-454.

Publication

Immunology
ISSN: 0019-2805
NlmUniqueID: 0374672
Country: England
Language: English
Volume: 21
Issue: 3
Pages: 443-454

Researcher Affiliations

Vaerman, J P
    Querinjean, P
      Heremans, J F

        MeSH Terms

        • Animals
        • Blood Protein Electrophoresis
        • Chromatography, DEAE-Cellulose
        • Chromatography, Gel
        • Cross Reactions
        • Horses / immunology
        • Humans
        • Immune Sera
        • Immunoelectrophoresis
        • Immunoglobulin A / analysis
        • Immunoglobulin G / analysis
        • Immunoglobulin G / metabolism
        • Intestines / immunology
        • Milk / immunology
        • Rabbits
        • Saliva / immunology

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