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Home / Equine Research Bank / Z Parasitenkd / Studies on the sequence of variable antigen types in ponies ...
Zeitschrift fur Parasitenkunde (Berlin, Germany)1986; 72(2); 145-151; doi: 10.1007/BF00931142

Studies on the sequence of variable antigen types in ponies infected with a clone of Trypanosoma evansi.

Abstract: The sequential appearance of variable antigen types (VATs) of a clone of Trypanosoma evansi was studied in four ponies. Using luminol-dependent chemiluminescence, VAT populations which had been isolated from parasitemic peaks of single ponies, were tested for specificity with serum samples collected from other ponies. When antibody activity was demonstrated in a combination of trypanosomes and serum, it was concluded that a major VAT appeared in common. In the serum of all animals antibody activity was demonstrated to all VAT populations isolated from the other ponies during the first 4 weeks of infection, indicating that up to this moment in all four animals the same major VATs developed. The sequence of major VATs was very similar in all ponies. Several parasitemic waves consisted of more than one major VAT, and in another pony a certain major VAT developed either in the same or in a neighbouring wave of the parasitemia.
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Publication Date: 1986-01-01 PubMed ID: 2422820DOI: 10.1007/BF00931142Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article focuses on studying the sequential appearance of variable antigen types (VATs) from a clone of Trypanosoma evansi in four ponies, with findings suggesting that the same major VATs appear in all ponies during the initial four weeks of infection.

Research Methodology

  • The researchers engaged a clone of Trypanosoma evansi, a parasite known to cause the disease trypanosomiasis in animals.
  • They studied the sequential appearance of Variable Antigen Types (VATs) in four ponies. VATs refer to the different versions of antigens that the parasite produces to evade the host’s immune system.
  • To examine the specificity of different VATs, they utilized a method called luminol-dependent chemiluminescence. It is a process that detects light emitted from an antigen-antibody reaction, thus indicating the presence of specific antibodies in the serum samples.

Findings

  • After identifying antibody activity by combining trypanosomes and serum, the researchers concluded that major VAT appeared common among all ponies.
  • This commonality extended to all VAT populations that were isolated from other ponies during the first four weeks of infection.
  • The sequence in which these major VATs appeared was extremely similar in all four ponies over the studied period.
  • The researchers further observed that several parasitemic waves (multiple peak and drop cycles of parasitic presence in the host, indicating host immune response and parasite evasion techniques) consisted of more than one major VAT.
  • It was also noted that the same major VAT developed either within the same wave or a neighbouring wave of parasitemia in another pony.

Conclusion

  • The study concluded that the same major Variable Antigen Types (VATs) are expressed by a clone of Trypanosoma evansi in all ponies during the first four weeks of infection.
  • This finding can shed new light on the complex host-parasite interaction, which is crucial for devising effective treatment strategies.

Cite This Article

APA
Diesing L, Steuber S, Ahmed JS, Hörchner F. (1986). Studies on the sequence of variable antigen types in ponies infected with a clone of Trypanosoma evansi. Z Parasitenkd, 72(2), 145-151. https://doi.org/10.1007/BF00931142

Publication

Zeitschrift fur Parasitenkunde (Berlin, Germany)
ISSN: 0044-3255
NlmUniqueID: 8710749
Country: Germany
Language: English
Volume: 72
Issue: 2
Pages: 145-151

Researcher Affiliations

Diesing, L
    Steuber, S
      Ahmed, J S
        Hörchner, F

          MeSH Terms

          • Animals
          • Antibody Specificity
          • Antigens, Protozoan / immunology
          • Epitopes
          • Horse Diseases / immunology
          • Horse Diseases / parasitology
          • Horses
          • Time Factors
          • Trypanosoma / immunology
          • Trypanosomiasis / immunology
          • Trypanosomiasis / parasitology
          • Trypanosomiasis / veterinary

          References

          This article includes 11 references
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            pubmed: 6084349
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            pubmed: 3997196doi: 10.1016/S0171-2985(85)80028-0google scholar: lookup
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          Citations

          This article has been cited 0 times.
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