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Home / Equine Research Bank / J Vet Intern Med / Successful application of closed loop stimulation pacemakers...
Journal of veterinary internal medicine2021; 35(6); 2920-2925; doi: 10.1111/jvim.16305

Successful application of closed loop stimulation pacemakers with remote monitoring in 3 miniature donkeys with syncope.

Abstract: Rate-adaptive single chamber pacemakers with accelerometer, closed loop stimulation (CLS), and remote monitoring functionality (Eluna 8 SR-T, Biotronik, SE & Co, Germany) were implanted in 3 miniature donkeys with third-degree atrioventricular block and syncope. After recovery, different pacemaker programming modes were tested at rest, during stress without physical exercise and during physical exercise. Pacing rates were compared to actual atrial rates and showed that CLS functionality allowed physiological heart rate adaptation. A transmitter installed in the stable provided wireless connection of the pacemaker to the internet. Home monitoring was activated which performed daily wireless transmission of pacemaker functional measurements to an online server allowing diagnosis of pathological arrhythmias and pacemaker malfunction from a distance. Closed loop stimulation and remote monitoring functionality resulted in nearly physiological rate adaptation and allowed remote "from-the-stable" patient follow-up.
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2021-11-06 PubMed ID: 34741540PubMed Central: PMC8692216DOI: 10.1111/jvim.16305Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research involved successful testing and application of rate-adaptive single chamber pacemakers with special features in three miniature donkeys that were experiencing third-degree atrioventricular block and fainting spells (syncope).

Introduction

  • The study was mainly focused on the use of advanced pacemakers known as Eluna 8 SR-T, designed by Biotronik, SE & Co, a German company.
  • All three donkeys who were part of the study had a medical condition called third-degree atrioventricular block, where the signal from the atria (upper chambers) to the ventricles (lower chambers) of the heart is completely blocked, and syncope — a condition which results in fainting due to insufficient blood flow to the brain.

Pacemaker Functionality and Monitoring

  • The selected pacemakers had innovative features like accelerometer detection, closed loop stimulation, and capability for remote monitoring.
  • These pacemakers were tested in various states – at rest, under stress without physical exertion, and during physical activities.
  • The functions of closed loop stimulation (CLS) and pacemaker programming modes were tested and pacing rates were compared to the actual atrial rates, which showed that CLS functionality allows physiological heart rate adaptation.

Remote Monitoring and Data Transmission

  • A key part of the study was to monitor the functionality of the device remotely, for which a transmitter was installed in the stable.
  • This transmitter allowed the pacemaker to connect wirelessly to the internet, thereby providing home monitoring capability.
  • The pacemaker was set up to perform daily wireless transmission of its functional data to an online server.

Outcome

  • This setup allowed the researchers to diagnose any pathological arrhythmias (improper beating of the heart, whether irregular, too fast, or slow) as well as any malfunction in the pacemaker from a remote location.
  • This meant that the monitoring of the donkeys’ health could be conducted from their stable, with minimal distress to the animals.
  • The study concluded that the use of CLS and remote monitoring led to semi-physiological rate adaptation, yielding positive results in patient follow-ups and offering a practical solution for managing the heart conditions in these animals.

Cite This Article

APA
De Lange L, Van Steenkiste G, Vernemmen I, Vera L, Cromheeke KMC, Walser U, Meert H, Decloedt A, van Loon G. (2021). Successful application of closed loop stimulation pacemakers with remote monitoring in 3 miniature donkeys with syncope. J Vet Intern Med, 35(6), 2920-2925. https://doi.org/10.1111/jvim.16305

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 35
Issue: 6
Pages: 2920-2925

Researcher Affiliations

De Lange, Lisa
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.
Van Steenkiste, Glenn
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vernemmen, Ingrid
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vera, Lisse
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.
Cromheeke, Kristel M C
  • Anegria, VZW Donkey Sanctuary, Sint-Gillis-Waas, Belgium.
Walser, Ulla
  • Biotronik Belgium, Vilvoorde, Belgium.
  • Biotronik SE & Co. KG, Berlin, Germany.
Meert, Hans
  • Biotronik Belgium, Vilvoorde, Belgium.
  • Biotronik SE & Co. KG, Berlin, Germany.
Decloedt, Annelies
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.
van Loon, Gunther
  • Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Merelbeke, Belgium.

MeSH Terms

  • Animals
  • Arrhythmias, Cardiac / veterinary
  • Atrioventricular Block / diagnosis
  • Atrioventricular Block / therapy
  • Atrioventricular Block / veterinary
  • Cardiac Pacing, Artificial / veterinary
  • Equidae
  • Pacemaker, Artificial / veterinary
  • Syncope / diagnosis
  • Syncope / therapy
  • Syncope / veterinary

Grant Funding

  • 01B05818 / Special Research Fund of Ghent University
  • 1S71521N / Research Foundation Flanders (FWO-Vlaanderen)
  • 1S56217N / Research Foundation Flanders (FWO-Vlaanderen)
  • 1134919N / Research Foundation Flanders (FWO-Vlaanderen)

Conflict of Interest Statement

Authors declare no conflict of interest.

References

This article includes 24 references
  1. Reef VB, Marr CM. Dysrhythmias: assessment and medical management. In: Marr CM, Bowen M, eds. Cardiology of the Horse. 2nd ed. Edinburgh, UK: Elsevier; 2010:159‐178.
  2. Keen JA. Pathological bradyarrhythmia in horses.. Vet J 2020 May-Jun;259-260:105463.
    pubmed: 32553234doi: 10.1016/j.tvjl.2020.105463google scholar: lookup
  3. van Loon G. Dysrhythmias: cardiac pacing and electrical cardioversion. In: Marr CM, Bowen M, eds. Cardiology of the Horse. 2nd ed. Edinburgh, UK: Elsevier; 2010:179‐192.
  4. Reef VB, Clark ES, Oliver JA, Donawick WJ. Implantation of a permanent transvenous pacing catheter in a horse with complete heart block and syncope.. J Am Vet Med Assoc 1986 Aug 15;189(4):449-52.
    pubmed: 3759616
  5. Pibarot P, Vrins A, Salmon Y, Difruscia R. Implantation of a programmable atrioventricular pacemaker in a donkey with complete atrioventricular block and syncope.. Equine Vet J 1993 May;25(3):248-51.
    pubmed: 8508758doi: 10.1111/j.2042-3306.1993.tb02955.xgoogle scholar: lookup
  6. van Loon G, Fonteyne W, Rottiers H, Tavernier R, Jordaens L, D'Hont L, Colpaert R, De Clercq T, Deprez P. Dual-chamber pacemaker implantation via the cephalic vein in healthy equids.. J Vet Intern Med 2001 Nov-Dec;15(6):564-71.
    pubmed: 11817062doi: 10.1892/0891-6640(2001)015<0564:dpivtc>2.3.co;2google scholar: lookup
  7. van Loon G, Fonteyne W, Rottiers H, Tavernier R, Deprez P. Implantation of a dual-chamber, rate-adaptive pacemaker in a horse with suspected sick sinus syndrome.. Vet Rec 2002 Nov 2;151(18):541-5.
    pubmed: 12448492doi: 10.1136/vr.151.18.541google scholar: lookup
  8. Ferasin L, Faena M, Henderson SM, Langford K, Darke PG. Use of a multi-stage exercise test to assess the responsiveness of rate-adaptive pacemakers in dogs.. J Small Anim Pract 2005 Mar;46(3):115-20.
    pubmed: 15789806doi: 10.1111/j.1748-5827.2005.tb00301.xgoogle scholar: lookup
  9. Roberts DH, Tennant B, Brockman D, Bellchambers S, Charles RG. Successful use of a QT-sensing rate-adaptive pacemaker in a dog.. Vet Rec 1992 May 23;130(21):471-2.
    pubmed: 1626358doi: 10.1136/vr.130.21.471google scholar: lookup
  10. Shortland J, Uzun O, Wilson D, Stuart GA, Walsh MA. Use of Biotronik closed loop pacemaker to treat recurrent syncope in pediatric patient with dysautonomia.. HeartRhythm Case Rep 2017 Jan;3(1):27-29.
    pmc: PMC5420039pubmed: 28491761doi: 10.1016/j.hrcr.2016.07.009google scholar: lookup
  11. Kuriachan V, Sheldo R. Role of pacing in neurally mediated syncope. In: Vonend O, Eckert S, eds. Aspects of Pacemakers ‐ Functions and Interactions in Cardiac and Non‐Cardiac Indications. Rijeka, Croatia: Intech; 2011:179‐194.
  12. Werner J, Hexamer M, Meine M, Hoeland K. Closed loop control of the heart by rate adaptive pacemakers. IFAC Proc Vol 1999;32(2):5668‐5673.
  13. de Ruvo E, Sciarra L, Martino AM, Rebecchi M, Iulianella RV, Sebastiani F, Fagagnini A, Borrelli A, Scarà A, Grieco D, Tota C, Stirpe F, Calò L. A prospective comparison of remote monitoring systems in implantable cardiac defibrillators: potential effects of frequency of transmissions.. J Interv Card Electrophysiol 2016 Jan;45(1):81-90.
    pubmed: 26467152doi: 10.1007/s10840-015-0067-4google scholar: lookup
  14. van Loon G, Laevens H, Deprez P. Temporary transvenous atrial pacing in horses: threshold determination.. Equine Vet J 2001 May;33(3):290-5.
    pubmed: 11352352doi: 10.2746/042516401776249633google scholar: lookup
  15. van Loon G, Van Steenkiste G, Vera L, Decloedt A. Catheter-based electrical interventions to study, diagnose and treat arrhythmias in horses: From refractory period to electro-anatomical mapping.. Vet J 2020 Sep;263:105519.
    pubmed: 32928488doi: 10.1016/j.tvjl.2020.105519google scholar: lookup
  16. Decloedt A. Prevalence of cardiovascular disease in donkeys.. Vet Rec 2016 Oct 15;179(15):382-383.
    pubmed: 27738220doi: 10.1136/vr.i5547google scholar: lookup
  17. Sedlinská M, Kabeš R, Novák M, Kološ F, Melková P. Single-Chamber Cardiac Pacemaker Implantation in a Donkey with Complete AV Block: A Long-Term Follow-Up.. Animals (Basel) 2021 Mar 9;11(3).
    pmc: PMC8000704pubmed: 33803127doi: 10.3390/ani11030746google scholar: lookup
  18. Hamir AN, Reef VB. Complications of a permanent transvenous pacing catheter in a horse.. J Comp Pathol 1989 Oct;101(3):317-26.
    pubmed: 2584450doi: 10.1016/0021-9975(89)90041-8google scholar: lookup
  19. Klug D, Balde M, Pavin D, Hidden-Lucet F, Clementy J, Sadoul N, Rey JL, Lande G, Lazarus A, Victor J, Barnay C, Grandbastien B, Kacet S. Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study.. Circulation 2007 Sep 18;116(12):1349-55.
    pubmed: 17724263doi: 10.1161/circulationaha.106.678664google scholar: lookup
  20. Fine DM, Tobias AH. Cardiovascular device infections in dogs: report of 8 cases and review of the literature.. J Vet Intern Med 2007 Nov-Dec;21(6):1265-71.
    pubmed: 18196736doi: 10.1892/07-019.1google scholar: lookup
  21. Wilkoff BL, Love CJ, Byrd CL, Bongiorni MG, Carrillo RG, Crossley GH 3rd, Epstein LM, Friedman RA, Kennergren CE, Mitkowski P, Schaerf RH, Wazni OM. Transvenous lead extraction: Heart Rhythm Society expert consensus on facilities, training, indications, and patient management: this document was endorsed by the American Heart Association (AHA).. Heart Rhythm 2009 Jul;6(7):1085-104.
    pubmed: 19560098doi: 10.1016/j.hrthm.2009.05.020google scholar: lookup
  22. Willems R. Implanted pacemakers, indications and novel programming. In: Vasan RS, Sawyer DB, eds. Encyclopedia of Cardiovascular Research and Medicine; Amsterdam, Netherlands: Elsevier; 2018:77‐86.
  23. Mulpuru SK, Madhavan M, McLeod CJ, Cha YM, Friedman PA. Cardiac Pacemakers: Function, Troubleshooting, and Management: Part 1 of a 2-Part Series.. J Am Coll Cardiol 2017 Jan 17;69(2):189-210.
    pubmed: 28081829doi: 10.1016/j.jacc.2016.10.061google scholar: lookup
  24. Steffen MM, Osborn JS, Cutler MJ. Cardiac Implantable Electronic Device Therapy: Permanent Pacemakers, Implantable Cardioverter Defibrillators, and Cardiac Resynchronization Devices.. Med Clin North Am 2019 Sep;103(5):931-943.
    pubmed: 31378335doi: 10.1016/j.mcna.2019.04.005google scholar: lookup

Citations

This article has been cited 4 times.
  1. Heun F, Niebuhr T, Gutierrez Bautista A, Wiedmann F, Verhaar N, Kästner S, Feige K, Schmidt C. Treatment of a Paroxysmal Atrioventricular Block by Implantation of a Bipolar, Single-Chamber Cardiac Pacemaker in a Donkey. Animals (Basel) 2023 Aug 27;13(17).
    doi: 10.3390/ani13172724pubmed: 37684988google scholar: lookup
  2. De Santis M, Seganfreddo S, Greco A, Normando S, Benedetti D, Mutinelli F, Contalbrigo L. Donkey Heart Rate and Heart Rate Variability: A Scoping Review. Animals (Basel) 2023 Jan 25;13(3).
    doi: 10.3390/ani13030408pubmed: 36766295google scholar: lookup
  3. Khamis TA, Shawaf T, El-Deeb W, Almubarak A, Al-Ali MA, Almuaqqil M, AlAiyan A, Homeida AM. Preliminary study on heart response and locomotor parameters in Donkeys (Equus asinus) during exercise using fitness tracker (Equimetre). Sci Rep 2024 Sep 27;14(1):22211.
    doi: 10.1038/s41598-024-72605-7pubmed: 39333304google scholar: lookup
  4. Avison A, Gelzer AR, Reef VB, Wulster Bills KB, de Solis CN, Kraus MS, Slack J, Stefanovski D, Deacon LJ, Underwood C. Twenty-four hour continuous transvenous temporary right ventricular pacing in healthy horses. J Vet Intern Med 2024 May-Jun;38(3):1751-1764.
    doi: 10.1111/jvim.17027pubmed: 38514200google scholar: lookup
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