Successful management of an equine carpal chip fracture by intra-articularly injected adipose-derived stromal vascular fraction after arthroscopic removal.
Abstract: Carpal chip fractures are common causes of lameness in racehorses. Due to disadvantages in surgical management, adjuvant treatment modalities are usually necessary. Adipose-derived stem cells (ADSCs) have the potential to differentiate into other cell types including bone and cartilage cells. Adipose-derived stromal vascular fraction (SVF) is produced during ADSCs isolation from adipose tissue. The purpose of this report was to present the successful management of a grade III chip fracture in the right carpus of a 5-year-old Thoroughbred gelding by intra-articularly injected autologous SVF one month after the arthroscopic removal of the fracture. This treatment resulted in lameness improvement and short rehabilitation period to previous racing activities. High performance levels and no recurrent injuries were recorded during a twenty month follow-up period.
Publication Date: 2016-09-23 PubMed ID: 27656232PubMed Central: PMC4898023DOI: 10.1155/2013/713959.Google Scholar: Lookup
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Summary
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This study discusses the successful treatment of a severe carpal chip fracture in a racehorse using adipose-derived stromal vascular fraction (SVF), a byproduct of stem cells, which was injected into the affected area after surgical removal of the fractured chip. The treatment resulted in improved lameness and enabled the horse to quickly return to racing with no recurrent injuries over a twenty-month period.
Background
- In racehorses, carpal chip fractures are a common cause of lameness. These injuries can often cause long lay-off periods and negatively affect the performance of the horse.
- Traditional surgical treatments have disadvantages, often necessitating supplementary treatments or therapies.
- Stem cell therapy, particularly adipose-derived stem cells (ADSCs), has shown promise in this area. ADSCs can differentiate into various cell types, including bone and cartilage cells, making them potentially effective in treating such injuries.
- During the stem cell isolation process from adipose (fat) tissues, the adipose-derived stromal vascular fraction (SVF) is produced, which has shown potential in treatment.
Methodology and Findings
- In this case study, the researchers document the effective management of a grade III carpal chip fracture – a serious injury – in a five-year-old Thoroughbred racehorse.
- The damaged chip was first removed arthroscopically (a minimally invasive surgical procedure).
- One month after the surgery, autologous (stemming from the horse itself) SVF was injected into the joint of the treated limb.
- The use of the horse’s own SVF cells avoided issues of immune rejection or disease transmission that could have occurred if cells from another horse were used.
Results and Conclusion
- The treatment resulted in a considerable improvement in the horse’s lameness, allowing it to return to racing much quicker than it might have following traditional surgical treatments alone.
- The researchers observed high performance levels in the horse following treatment and rehabilitation, indicating an effective recovery.
- No recurrent injuries were recorded during the twenty-month follow-up period, demonstrating the treatment’s long-term effectiveness.
- This case study shows the promising potential of using SVF therapy as an adjuvant treatment for healing carpal chip fractures in racehorses.
Cite This Article
APA
Tyrnenopoulou P, Karayannopoulou M, Angelopoulou S, Pyrros A, Mparous E, Koliakos G, Diakakis N.
(2016).
Successful management of an equine carpal chip fracture by intra-articularly injected adipose-derived stromal vascular fraction after arthroscopic removal.
Iran J Vet Res, 17(1), 59-61.
https://doi.org/10.1155/2013/713959. Publication
Researcher Affiliations
- Post-Graduate Student, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Greece;
- Department of Clinical Studies, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Greece;
- Veterinary Clinic, Athens Horse Racing Track, Markopoulo Mesogaias 190 03, Athens, Greece;
- Veterinary Clinic, Athens Horse Racing Track, Markopoulo Mesogaias 190 03, Athens, Greece;
- Veterinary Clinic, Athens Horse Racing Track, Markopoulo Mesogaias 190 03, Athens, Greece;
- Department of Biochemistry, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
- Department of Clinical Studies, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 27 Thessaloniki, Greece;
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Citations
This article has been cited 3 times.- Veronesi F, Maglio M, Contartese D, Martini L, Muttini A, Fini M. Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine. Stem Cells Int 2021;2021:6632052.
- Kamenaga T, Kuroda Y, Nagai K, Tsubosaka M, Takashima Y, Kikuchi K, Fujita M, Ikuta K, Anjiki K, Maeda T, Nakano N, Takayama K, Hashimoto S, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model. Stem Cell Res Ther 2021 Feb 4;12(1):110.
- Born S, Dörfel MJ, Hartjen P, Haschemi Yekani SA, Luecke J, Meutsch JK, Westphal JK, Birkelbach M, Köhnke R, Smeets R, Krueger M. A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product. Bioimpacts 2019;9(3):161-172.
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