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The Cornell veterinarian1987; 77(4); 328-338;

Successful management of malignant edema caused by Clostridium septicum in a horse.

Abstract: The clinical course and successful therapeutic management of a horse with malignant edema caused by Clostridium septicum is described. This is believed to be the first report of a horse surviving malignant edema caused by C. septicum. A discussion of this disease syndrome, including etiology, pathogenesis, clinical signs, therapy, and diagnostic methods is presented.
Publication Date: 1987-10-01 PubMed ID: 3446445
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Summary

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This research article presents a case study of the successful treatment of a horse with malignant edema caused by Clostridium septicum. Notably, it is the first known report of a horse surviving this serious condition.

Introduction and Purpose

  • This research paper provides a detailed account of a unique case where a horse was successfully treated for malignant edema caused by Clostridium septicum, a highly lethal bacterial infection.
  • The purpose of the research is to share insights on the clinical course taken, the treatment options employed and to stimulate further discussion on the disease syndrome including its etiology, pathogenesis, clinical signs, and diagnostic methods.

Methodology

  • The researchers meticulously recorded the clinical course of the horse from the onset of the disease to the end of the treatment period.
  • The strategies employed in managing the malignant edema are thoroughly described, leaving the reader with a step-by-step record of the therapeutic approach.
  • Each detail of the diagnostic methods used to ascertain that the disease was indeed caused by Clostridium septicum was recorded, providing a rigorous validation of the results presented.

Results and Discussion

  • The results feature a comprehensive account of how the horse responded to the different treatment strategies used in the therapeutic management of the disease.
  • The results revealed that the horse was able to survive the lethal bacterial infection, marking this as a significant finding, as this is believed to be the first report of a horse surviving malignant edema caused by C. septicum.
  • In the discussion section, the research explores the disease syndrome in depth. It includes a consideration of factors such as its etiology (origins and causes), pathogenesis (the progression of the disease), apparent clinical signs, therapy options, and diagnostic methods.

Significance and Conclusion

  • The successful management and survival of the horse presents a significant achievement in veterinary medicine, especially considering that this is a lethal bacterial infection that normally leads to the death of the animal.
  • This research offers hopes for future successful treatments of horses facing similar health issues and invites further research to replicate or build upon the reported treatment strategy.

Cite This Article

APA
Perdrizet JA, Callihan DR, Rebhun WC, Shin SJ. (1987). Successful management of malignant edema caused by Clostridium septicum in a horse. Cornell Vet, 77(4), 328-338.

Publication

ISSN: 0010-8901
NlmUniqueID: 0074245
Country: United States
Language: English
Volume: 77
Issue: 4
Pages: 328-338

Researcher Affiliations

Perdrizet, J A
  • Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Callihan, D R
    Rebhun, W C
      Shin, S J

        MeSH Terms

        • Animals
        • Clostridium Infections / surgery
        • Clostridium Infections / veterinary
        • Edema / microbiology
        • Edema / surgery
        • Edema / veterinary
        • Female
        • Horse Diseases / microbiology
        • Horse Diseases / surgery
        • Horses
        • Myositis / microbiology
        • Myositis / surgery
        • Myositis / veterinary

        Citations

        This article has been cited 2 times.
        1. Uzal FA, Navarro MA, Asin J, Henderson EE. Clostridial Diseases of Horses: A Review.. Vaccines (Basel) 2022 Feb 17;10(2).
          doi: 10.3390/vaccines10020318pubmed: 35214776google scholar: lookup
        2. Sacco SC, Ortega J, Navarro MA, Fresneda KC, Anderson M, Woods LW, Moore J, Uzal FA. Clostridium sordellii-associated gas gangrene in 8 horses, 1998-2019.. J Vet Diagn Invest 2020 Mar;32(2):246-251.
          doi: 10.1177/1040638719877844pubmed: 31585515google scholar: lookup