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Home / Equine Research Bank / Immunology / Suppression of synthesis of an IgG subclass in a persistent ...
Immunology1976; 30(1); 17-24;

Suppression of synthesis of an IgG subclass in a persistent viral infection.

Abstract: Comparison of immunoglobulin levels of nine horses before and after infection with equine infectious anaemia (EIA) virus demonstrated a significant depression of serum IgG(T) at 2 months (P less than 0-001) and at 1 year (P less than 0-01) after infection. In contrast, the levels of IgGa were significantly increased at both times after infection. Another sixteen horses with EIA for 1-4 months were examined and there was also significant depression (P less than 0-001) of IgG(T) when compared to pre-infection levels. No significant changes in IgG(T), IgGa and IgM were noted in fourteen normal horses housed for 2-7 months in the same manner as infected horses. Following DNP immunization there was a significant (P less than 0-02) decrease in the amount of IgG(T) antibody produced in five horses with EIA when compared to five normal horses. Metabolism studies with iodinated IgG(T) showed a significant (P less than 0-001) decrease in synthesis of this immunoglobulin in EIA-infected horses when compared to normal horses. Amounts of IgGa synthesized were similar in the two groups. Thus, persistent EIA viral infection suppresses the synthesis of IgG(T), an IgG subclass, without suppressing IgGa.
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Publication Date: 1976-01-01 PubMed ID: 814077PubMed Central: PMC1444966
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  • Journal Article
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  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper investigates the impact of equine infectious anemia (EIA) virus on the immunoglobulin levels of horses, revealing a significant reduction in the production of the IgG(T) subclass of immunoglobulin, despite an increase in the levels of IgGa.

Research Overview

The research compares the levels of immunoglobulins (IgG(T), IgG(a), and IgM) in infected and non-infected horses. Immunoglobulins are proteins produced by the body’s immune system to fight infections. In specific, the authors are interested in understanding how a persistent infection with the EIA virus impacts the production and response of these immunoglobulins.

  • The study involved two sets of horses: one set that was infected with the EIA virus and another set that was not infected.
  • The infected set consisted of nine horses examined post-infection and another sixteen horses examined between 1-4 months post-infection.
  • The non-infected set consisted of fourteen healthy horses kept under the same conditions as the infected horses.

Findings

The findings of this research centered on the impact of EIA virus on the synthesis of different types of immunoglobulins.

  • There was a significant decrease in serum IgG(T) levels in infected horses at 2 months and 1 year after infection, demonstrated through statistical significance (P less than 0.001 and 0.01 respectively).
  • Conversely, levels of IgGa were substantially elevated at both intervals after infection.
  • The second group of sixteen horses infected between 1-4 months also showed a significant decrease in IgG(T) levels compared to pre-infection measurements (P less than 0.001).
  • No significant change in levels of IgG(T), IgGa, and IgM was noted in fourteen healthy horses kept under similar conditions as infected horses.
  • Furthermore, after immunization with DNP (a type of antigen that triggers an immune response), there was a notable decrease in the amount of IgG(T) produced in EIA-infected horses compared to healthy horses.
  • Lastly, metabolic studies indicated a significant decrease in the synthesis of IgG(T) in infected horses, while levels of IgGa synthesis remained comparable in both groups.

Conclusion

The research concludes that a persistent EIA viral infection suppresses the synthesis of the IgG(T) subclass of immunoglobulins, without impacting the synthesis of IgGa. These findings offer important insights into maximizing the efficacy of vaccines and therapeutics for diseases caused by persistent viral infections.

Cite This Article

APA
McGuire TC. (1976). Suppression of synthesis of an IgG subclass in a persistent viral infection. Immunology, 30(1), 17-24.

Publication

Immunology
ISSN: 0019-2805
NlmUniqueID: 0374672
Country: England
Language: English
Volume: 30
Issue: 1
Pages: 17-24

Researcher Affiliations

McGuire, T C

    MeSH Terms

    • Animals
    • Antibody Formation
    • B-Lymphocytes / immunology
    • Dinitrophenols / immunology
    • Equine Infectious Anemia / immunology
    • Horses
    • Immunization
    • Immunodiffusion
    • Immunoglobulin G / analysis
    • Immunoglobulin G / biosynthesis
    • Immunoglobulin G / metabolism
    • Immunoglobulin M / analysis
    • Immunosuppression Therapy

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    Citations

    This article has been cited 5 times.
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