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Home / Equine Research Bank / Immunology / Surface receptors on neutrophils and monocytes from immunode...
Immunology1975; 28(3); 581-588;

Surface receptors on neutrophils and monocytes from immunodeficient and normal horses.

Abstract: Surface receptors on peripheral blood neutrophils and monocytes from normal and immunodeficient horses have been studied. Sheep erythrocytes (SRBC) coated with IgG, IgM, and complement but not IgG(T), readily bound to normal equine monocytes and neutrophils. More than 4000 molecules of IgG were required to sensitize each SRBC for adherence to monocytes, and more than 12,000 molecules were required for adherence to neutrophils. Young horses with a severe combined immunodeficiency had an almost total absence of lymphocytes, but normal numbers of monocytes and neutrophils. The number of receptors for immunoglobulin, complement, and phytolectin on monocytes and neutrophils from immunodeficient animals were similar to those on the cells of normal horses. Although the precursor cells of lymphocytes of horses with combined immunodeficiency appear to be defective, no defect in the other cellular products of the bone marrow were apparent.
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Publication Date: 1975-03-01 PubMed ID: 1126740PubMed Central: PMC1445792
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research looks at the surface receptors on certain white blood cells (neutrophils and monocytes) in both normal and immunodeficient horses, and found that the amount of these receptors in immunodeficient horses is similar to normal horses, suggesting that while lymphocytes are defective in these animals, other cells of the bone marrow are not.

Study of Surface Receptors

  • The research centered on studying the surface receptors on neutrophils and monocytes, types of white blood cells that are key to our immune responses, from both immunodeficient and normal horses.
  • Prior to the onset of the experiment, sheep red blood cells (SRBC) coated with specific types of antibodies (IgG and IgM) and complement proteins were created. A significant finding was that they were able to bind readily to normal horse monocytes and neutrophils, indicating a functional immune response in healthy horses. As part of this process, scientists discovered that over 4000 molecules of IgG were required for each SRBC to adhere to monocytes, and over 12,000 molecules of IgG for adherence to neutrophils.

Immunodeficient Horses

  • Young horses showing severe combined immunodeficiency (SCID), a genetic disorder that results in a compromised immune system, were also studied. The researchers found these horses had almost no lymphocytes – special types of white blood cells that protect the body from infections. However, the number of monocytes and neutrophils were normal.
  • In contrast to the lack of lymphocytes, the amounts of receptors for immunoglobulin (a type of antibody), complement, and phytolectin found in the monocytes and neutrophils of these immunodeficient animals were similar to those seen in the cells of healthy, normal horses. This indicates that while the progenitor cells – cells that differentiate to become lymphocytes – appear dysfunctional in the SCID horses, no obvious defect with other cell types produced in the bone marrow could be discerned.

Implications and Conclusion

  • The research sheds light on the immune response mechanism in horses, crucially comparing healthy and immunocompromised equine immune system function.
  • The unique element of this study was the finding that despite the lack of lymphocytes in immunodeficient horses, other essential immune cells appear to remain unaffected and fully functional. Future studies could explore whether this is a generalized trait in immunodeficient mammals or a specific feature of the equine immune system.

Cite This Article

APA
Banks KL, McGuire TC. (1975). Surface receptors on neutrophils and monocytes from immunodeficient and normal horses. Immunology, 28(3), 581-588.

Publication

Immunology
ISSN: 0019-2805
NlmUniqueID: 0374672
Country: England
Language: English
Volume: 28
Issue: 3
Pages: 581-588

Researcher Affiliations

Banks, K L
    McGuire, T C

      MeSH Terms

      • Age Factors
      • Animals
      • Binding Sites
      • Bone Marrow / immunology
      • Bone Marrow Cells
      • Cell Membrane / immunology
      • Complement System Proteins
      • Erythrocytes / immunology
      • Horse Diseases / immunology
      • Horses / immunology
      • Immune Adherence Reaction
      • Immunization
      • Immunoglobulins
      • Immunologic Deficiency Syndromes / immunology
      • Immunologic Deficiency Syndromes / veterinary
      • Lymphocytes / analysis
      • Monocytes / immunology
      • Neutrophils / immunology
      • Protein Precursors
      • Sheep / immunology

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