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Veterinary ophthalmology2001; 1(2-3); 137-151; doi: 10.1046/j.1463-5224.1998.00030.x

Surgical management of equine recurrent uveitis with single port pars plana vitrectomy.

Abstract: Current information suggests that equine recurrent uveitis (ERU) is an immune-mediated reaction to infectious agents or to autologous ophthalmic tissue. Recurrences are associated with progression of irreversible ocular damage. This report describes the intraoperative technique, complications, and long-term results of 38 eyes in 35 horses with ERU that underwent pars plana vitrectomy. The majority of the horses were warm-blooded. Recurrence of ERU was prevented in 35 of the 38 eyes. Some horses, especially in patients with incipient cataracts, developed vision loss in postoperative, quiescent eyes which was usually associated with cataract formation. Vision was stable in 85% of all eyes that underwent vitrectomy. Pars plana vitrectomy in horses appears successful in interrupting the cycle of repeated episodes of ERU, and the subsequent globe destruction in the majority of eyes. Removal of uveitis-induced 'immunologic memory' in the vitreous by vitrectomy may reduce adverse interaction between the vitreous and the uveal tract, and therefore reduce the recurrence of ERU.
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Publication Date: 2001-06-09 PubMed ID: 11397223DOI: 10.1046/j.1463-5224.1998.00030.xGoogle Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article studies the effectiveness of single port pars plana vitrectomy, a surgical procedure, in preventing recurrence of equine recurrent uveitis (ERU), an immune-mediated eye condition in horses. The study found the procedure to be successful in the majority of cases, with the potential to inhibit the repetition of ERU episodes and thus prevent further ocular damage.

Research Objective and Method

  • The main objective of this research was to study the effectiveness of a surgical method called single port pars plana vitrectomy in preventing the recurrence of equine recurrent uveitis (ERU) which is an inflammation in the uveal tract of horses’ eyes caused by immune response.
  • The study was based on the results obtained from 38 eyes of 35 horses that underwent the surgical procedure. The evaluation was based upon the intraoperative technique, complications, and the long-term results post-surgery.

Results and Findings

  • The research findings were positive with the recurrence of ERU prevented in 35 out of the 38 eyes that underwent the surgical procedure.
  • The surgical procedure was found to be particularly effective in warm-blooded horses.
  • However, there were complications with some horses, particularly those with incipient cataracts, experiencing vision loss in the quiescent eyes post-surgery. This was usually associated with cataract formation.
  • Despite the complications, the research concluded that vision remained stable in 85% of all eyes that underwent vitrectomy.

Interpretation and Conclusions

  • This research concluded that pars plana vitrectomy could be successful in preventing the recurrence and progression of ERU in horses.
  • By removing the ‘immunologic memory’ in the vitreous, which is presumed to induce uveitis, the adverse interactions between the vitreous and uveal tract were reduced, thereby reducing the probability of ERU recurrence.
  • This surgical procedure, therefore, holds potential in interrupting the cycle of repeated episodes of ERU, preventing subsequent globe destruction in the majority of the cases.

Cite This Article

APA
Frühauf B, Ohnesorge B, Deegen E, Boevé M. (2001). Surgical management of equine recurrent uveitis with single port pars plana vitrectomy. Vet Ophthalmol, 1(2-3), 137-151. https://doi.org/10.1046/j.1463-5224.1998.00030.x

Publication

Veterinary ophthalmology
ISSN: 1463-5224
NlmUniqueID: 100887377
Country: England
Language: English
Volume: 1
Issue: 2-3
Pages: 137-151

Researcher Affiliations

Frühauf, B.
  • Clinic for Horses, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany; Clinic for Horses, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany; Clinic for Horses, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany; Clinic for Horses, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany.
Ohnesorge, B.
    Deegen, E.
      Boevé, M.

        Citations

        This article has been cited 9 times.
        1. Kalinovskiy A, Leser S, Ehrle A, Reese S, Jones S, Gerhards H. Phacoemulsification Combined with Pars Plana Vitrectomy: Outcome in Horses with Acquired Cataracts Associated with Uveitis. Animals (Basel) 2024 Apr 16;14(8).
          doi: 10.3390/ani14081192pubmed: 38672339google scholar: lookup
        2. Morén S, Kallberg M, Strom L. Equine uveitis: Outcome and adverse effects after one or two intravitreal low-dose gentamicin injections. Equine Vet J 2025 Jan;57(1):160-168.
          doi: 10.1111/evj.14056pubmed: 38329024google scholar: lookup
        3. Geiger T, Gerhards H, Bjelica B, Mackenthun E, Wollanke B. Analysis of 1840 Equine Intraocular Fluid Samples for the Presence of Anti-Leptospira Antibodies and Leptospiral DNA and the Correlation to Ophthalmologic Findings in Terms of Equine Recurrent Uveitis (ERU)-A Retrospective Study. Vet Sci 2022 Aug 21;9(8).
          doi: 10.3390/vetsci9080448pubmed: 36006363google scholar: lookup
        4. Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
          doi: 10.3390/microorganisms10020387pubmed: 35208842google scholar: lookup
        5. Geiger T, Gerhards H, Wollanke B. Detection of Anti-LipL32 Antibodies in Serum Samples from Horses with Chronic Intraocular Infection with Leptospira spp. Pathogens 2021 Oct 14;10(10).
          doi: 10.3390/pathogens10101325pubmed: 34684272google scholar: lookup
        6. Fischer BM, McMullen RJ Jr, Reese S, Brehm W. Intravitreal injection of low-dose gentamicin for the treatment of recurrent or persistent uveitis in horses: Preliminary results. BMC Vet Res 2019 Jan 16;15(1):29.
          doi: 10.1186/s12917-018-1722-7pubmed: 30651102google scholar: lookup
        7. Malalana F, Blundell RJ, Pinchbeck GL, Mcgowan CM. The role of Leptospira spp. in horses affected with recurrent uveitis in the UK. Equine Vet J 2017 Nov;49(6):706-709.
          doi: 10.1111/evj.12683pubmed: 28321895google scholar: lookup
        8. Degroote RL, Hauck SM, Amann B, Hirmer S, Ueffing M, Deeg CA. Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis. PLoS One 2014;9(3):e91684.
          doi: 10.1371/journal.pone.0091684pubmed: 24614191google scholar: lookup
        9. Sandmeyer LS, Grahn BH, Breaux CB. Diagnostic ophthalmology. Anterior and posterior uveitis with inflammatory retinal detachment, most likely secondary to equine recurrent uveitis. Can Vet J 2007 Jan;48(1):97-8.
          pubmed: 17310629
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