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Home / Equine Research Bank / Equine Vet J / Surgical osteochondral defect repair in the horse-a matter o...
Equine veterinary journal2020; 52(4); 489-499; doi: 10.1111/evj.13231

Surgical osteochondral defect repair in the horse-a matter of form or function?

Abstract: Focal cartilaginous and osteochondral lesions can have traumatic or chondropathic degenerative origin. The fibrocartilaginous repair tissue that forms naturally, eventually undergoes fibrillation and degeneration leading to further disruption of joint homeostasis. Both types of lesion will therefore eventually lead to activity-related pain, swelling and decreased mobility and will frequently progress to osteoarthritis. Most attempts at realising cartilage regeneration have so far resulted in cartilage repair (and not regeneration). The aim of this article was to review experimental research on surgical cartilage restoration techniques performed so far in equine models. Currently available surgical options for treatment of osteochondral lesions in the horse are summarised. The experimental validity of equine experimental models is addressed and finally possible avenues for further research are discussed.
© 2020 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
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Publication Date: 2020-02-19 PubMed ID: 31958175PubMed Central: PMC7317185DOI: 10.1111/evj.13231Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the efficacy and advancements in surgical techniques for healing focal cartilaginous and osteochondral lesions in horses. The lesions, whether originated traumatically or via degenerative conditions, usually result in pain, reduced mobility, swelling, and often progress to osteoarthritis.

Objective of the Research

  • The research seeks to review the experimental studies done on cartilage restoration surgical techniques applied in equine models.
  • It also aims to provide a summary of the currently available surgical options to treat osteochondral lesions in horses.
  • The paper addresses the experimental validity of equine models used in these studies and suggests potential areas for future research in this field.

The Problem of Cartilage Damage

  • Cartilage and osteochondral lesions can either arise from trauma or degenerative conditions that disrupt the joint’s normal function.
  • The natural reaction to such lesions is the formation of fibrocartilaginous repair tissue, which ultimately undergoes fibrillation and degeneration, resulting in further disruption of joint homeostasis.
  • These lesions often lead to activity-related pain, swelling and decreased mobility, and frequently progress to osteoarthritis, a condition in which the protective cartilage that cushions the ends of the bones within the joints gradually wears away.

Current Solutions and Their Limitations

  • Although there have been attempts to regenerate cartilage, so far most have resulted in cartilage repair, not actual regeneration.
  • While repair is beneficial, it may not bring back the original functionality and strength of the original cartilage.
  • Hence, there is a necessity to continually develop and improve surgical techniques that can effectively treat the lesions and possibly lead towards true cartilage regeneration.

Validation of Equine Models

  • The paper also scrutinizes the experimental validity of equine models used in the studies.
  • Using horses as models to study cartilage restoration has been deemed as valid because horses share similar joint problems with humans due to similar joint sizes and load conditions.
  • By studying these equine models, researchers hope to further extend their understanding and discovery of therapy applicable for humans too.

Future Research Directions

  • The paper concludes by pointing out some potential areas for further research in the field of osteochondral lesions repair.
  • This aims to motivate further exploration and innovation to improve both current treatment procedures and aftercare for osteochondral defect repair, not only in horses but also in other animals and humans.

Cite This Article

APA
Fugazzola MC, van Weeren PR. (2020). Surgical osteochondral defect repair in the horse-a matter of form or function? Equine Vet J, 52(4), 489-499. https://doi.org/10.1111/evj.13231

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 52
Issue: 4
Pages: 489-499

Researcher Affiliations

Fugazzola, Maria C
  • Department of Equine Sciences, Utrecht University, Utrecht, the Netherlands.
van Weeren, Paul R
  • Department of Equine Sciences, Utrecht University, Utrecht, the Netherlands.

MeSH Terms

  • Animals
  • Cartilage, Articular
  • Horse Diseases
  • Horses
  • Osteoarthritis / veterinary
  • Wound Healing

Conflict of Interest Statement

No competing interests have been declared.

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Citations

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  1. Ajeeb B, Kiyotake EA, Keefe PA, Phillips JN, Hatzel JN, Goodrich LR, Detamore MS. Comparison of the chondrogenic potential of eBMSCs and eUCMSCs in response to selected peptides and compounds. BMC Vet Res 2025 Feb 17;21(1):70.
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  2. Canonici F, Cocumelli C, Cersini A, Marcoccia D, Zepparoni A, Altigeri A, Caciolo D, Roncoroni C, Monteleone V, Innocenzi E, Alimonti C, Ghisellini P, Rando C, Pechkova E, Eggenhöffner R, Scicluna MT, Barbaro K. Articular Cartilage Regeneration by Hyaline Chondrocytes: A Case Study in Equine Model and Outcomes. Biomedicines 2023 May 31;11(6).
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