FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2006; 18(1); 123-126; doi: 10.1177/104063870601800121

Survey of equine cutaneous neoplasia in the Pacific Northwest.

Abstract: A retrospective study examined data regarding equine cutaneous and mucocutaneous neoplasms submitted to the Veterinary Diagnostic Laboratory at Oregon State University in a 3.5-year period. A total of 536 neoplasms were identified, accounting for 30% of the total equine pathology submissions. Sarcoid, squamous cell carcinoma, melanocytic tumors, papillomas, and mast cell tumors were the most common neoplasms, constituting 87.5% of all cutaneous neoplasms. Sarcoids represented 51.4% of all neoplasms and 15.18% of total equine accessions. Sarcoid was most common in paints, quarter horses, and Arabians, and was the only common tumor in donkeys and mules. Mean age at diagnosis of equine sarcoid was 9 years. Squamous cell carcinoma constituted 18.3% of all neoplasms and 5.41% of total equine accessions. Ocular squamous cell carcinoma was most common in paints and quarter horses, and penile/preputial squamous cell carcinoma was most common in appaloosas and quarter horses. The mean age of horses with ocular squamous cell carcinoma (13 years) and squamous cell carcinoma of the skin (15 years) was significantly less (P < 0.5) than that of horses with squamous cell carcinoma of the penis and prepuce (21 years) or vulva, anal, and perianal skin (19 years). Findings suggest that equine sarcoid and squamous cell carcinoma occur more frequently in the Pacific Northwest than in the northeastern United States.
Get Full Text
Publication Date: 2006-03-29 PubMed ID: 16566271DOI: 10.1177/104063870601800121Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper examines the occurrence of skin and mucous membrane tumors in horses in the Pacific Northwest, with the common types being Sarcoid, Squamous cell carcinoma, melanocytic tumors, papillomas, and mast cell tumors, as recorded over a 3.5 years period at the Veterinary Diagnostic Laboratory at Oregon State University.

Methodology and Data Collection

  • The research was conducted retrospectively, examining past records and submissions to the Veterinary Diagnostic Laboratory at Oregon State University.
  • They analysed data over a period of three and a half years, focusing on the pathology submissions related to equine cutaneous (skin) and mucocutaneous (mucous membrane and skin) neoplasms or tumors.
  • A total of 536 neoplasms were identified, making up 30% of the total equine pathology submissions over the period.

Findings

  • The most frequently found tumors were Sarcoids constituting approximately 51.4% of all identified neoplasms and 15.18% of the total equine accessions.
  • This was followed by Squamous cell carcinoma making up 18.3% of all neoplasms and 5.41% of all equine pathology submissions.
  • Other prevalent tumors included melanocytic tumors, papillomas, and mast cell tumors. Together with the Sarcoids and Squamous cell carcinoma, these made up 87.5% of the identified skin neoplasms.
  • Sarcoids were most common in Paints, Quarter horses, and Arabians and were the only common tumor found in Donkeys and Mules. The average age at diagnosis was nine years.
  • Ocular Squamous cell carcinoma was most frequently found in Paints and Quarter horses. On the other hand, penile/preputial Squamous cell carcinoma was most common in Appaloosas and Quarter horses.
  • The mean age of horses with ocular Squamous cell carcinoma and Squamous cell carcinoma of the skin was statistically significantly lower than those with Squamous cell carcinoma of the penis and prepuce or of the vulva, anal, and perianal skin.

Conclusions

  • The findings suggest that the occurrence of equine Sarcoid and Squamous cell carcinoma is higher in the Pacific Northwest as compared to the northeastern United States.
  • Further, certain breeds of horses (like Paints, Quarter horses, and Arabians) and mules/ donkeys presented specific vulnerability to certain types of neoplasms.
  • Age was also seen to be an important factor, with specific types of cancer more common in certain age groups.

Cite This Article

APA
Valentine BA. (2006). Survey of equine cutaneous neoplasia in the Pacific Northwest. J Vet Diagn Invest, 18(1), 123-126. https://doi.org/10.1177/104063870601800121

Publication

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
ISSN: 1040-6387
NlmUniqueID: 9011490
Country: United States
Language: English
Volume: 18
Issue: 1
Pages: 123-126

Researcher Affiliations

Valentine, Beth A
  • Veterinary Diagnostic Laboratory and Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA.

MeSH Terms

  • Animals
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / veterinary
  • Horse Diseases / epidemiology
  • Horses
  • Incidence
  • Melanoma / epidemiology
  • Melanoma / veterinary
  • Nevus, Pigmented / epidemiology
  • Nevus, Pigmented / veterinary
  • Northwestern United States / epidemiology
  • Papilloma / epidemiology
  • Papilloma / veterinary
  • Retrospective Studies
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / veterinary

Citations

This article has been cited 20 times.
  1. Hamza E, Cosandey J, Gerber V, Koch C, Unger L. The potential of three whole blood microRNAs to predict outcome and monitor treatment response in sarcoid-bearing equids. Vet Res Commun 2023 Jan;47(1):87-98.
    doi: 10.1007/s11259-022-09930-7pubmed: 35484337google scholar: lookup
  2. Cosandey J, Hamza E, Gerber V, Ramseyer A, Leeb T, Jagannathan V, Blaszczyk K, Unger L. Diagnostic and prognostic potential of eight whole blood microRNAs for equine sarcoid disease. PLoS One 2021;16(12):e0261076.
    doi: 10.1371/journal.pone.0261076pubmed: 34941894google scholar: lookup
  3. Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Minato E, Kobayashi A, Ando R, Sasaki N, Miyakoshi D, Ichii O, Kato Y, Suzuki Y, Murata S, Ohashi K. PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade. PLoS One 2020;15(11):e0234218.
    doi: 10.1371/journal.pone.0234218pubmed: 33216754google scholar: lookup
  4. Weber LA, Funtan A, Paschke R, Delarocque J, Kalbitz J, Meißner J, Feige K, Kietzmann M, Cavalleri JV. In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer. PLoS One 2020;15(11):e0241448.
    doi: 10.1371/journal.pone.0241448pubmed: 33151949google scholar: lookup
  5. Arthurs C, Suarez-Bonnet A, Willis C, Xie B, Machulla N, Mair TS, Cao K, Millar M, Thrasivoulou C, Priestnall SL, Ahmed A. Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2. Sci Rep 2020 May 12;10(1):7863.
    doi: 10.1038/s41598-020-64014-3pubmed: 32398763google scholar: lookup
  6. Tamlin VS, Bottema CDK, Peaston AE. Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment. Vet Med Sci 2020 Feb;6(1):3-18.
    doi: 10.1002/vms3.201pubmed: 31650704google scholar: lookup
  7. Prouteau A, André C. Canine Melanomas as Models for Human Melanomas: Clinical, Histological, and Genetic Comparison. Genes (Basel) 2019 Jun 30;10(7).
    doi: 10.3390/genes10070501pubmed: 31262050google scholar: lookup
  8. Poore LA, Duncan N, Williams J. Unilateral subcutaneous fibroma in the distal femoral region of a 5-year-old Nooitgedacht mare. J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e4.
    doi: 10.4102/jsava.v89i0.1636pubmed: 30551706google scholar: lookup
  9. Unger L, Jagannathan V, Pacholewska A, Leeb T, Gerber V. Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression. J Vet Intern Med 2019 Jan;33(1):241-250.
    doi: 10.1111/jvim.15375pubmed: 30506726google scholar: lookup
  10. Spugnini EP, Bolaffio C, Scacco L, Baldi A. Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion. Open Vet J 2016;6(3):234-237.
    doi: 10.4314/ovj.v6i3.12pubmed: 27995080google scholar: lookup
  11. Rizk A, Mosbah E, Karrouf G, Abou Alsoud M. Surgical Management of Penile and Preputial Neoplasms in Equine with Special Reference to Partial Phallectomy. J Vet Med 2013;2013:891413.
    doi: 10.1155/2013/891413pubmed: 26464915google scholar: lookup
  12. van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T, Arends MJ, Adams DJ. Cross-species models of human melanoma. J Pathol 2016 Jan;238(2):152-65.
    doi: 10.1002/path.4632pubmed: 26354726google scholar: lookup
  13. Schnabel CL, Steinig P, Koy M, Schuberth HJ, Juhls C, Oswald D, Wittig B, Willenbrock S, Murua Escobar H, Pfarrer C, Wagner B, Jaehnig P, Moritz A, Feige K, Cavalleri JM. Immune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent. BMC Vet Res 2015 Jun 23;11:140.
    doi: 10.1186/s12917-015-0452-3pubmed: 26100265google scholar: lookup
  14. Yaghoobi Yeganeh Manesh J, Shafiee R, Mohammad Bahrami A, Pourzaer M, Pourzaer M, Pedram B, Javanbakht J, Mokarizadeh A, Khadivar F. Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog. Diagn Pathol 2014 Jun 6;9:110.
    doi: 10.1186/1746-1596-9-110pubmed: 24903567google scholar: lookup
  15. Maglennon GA, Doorbar J. The biology of papillomavirus latency. Open Virol J 2012;6:190-7.
    doi: 10.2174/1874357901206010190pubmed: 23341854google scholar: lookup
  16. Wobeser BK, Davies JL, Hill JE, Jackson ML, Kidney BA, Mayer MN, Townsend HG, Allen AL. Epidemiology of equine sarcoids in horses in western Canada. Can Vet J 2010 Oct;51(10):1103-8.
    pubmed: 21197201
  17. Beermann A, Hamza E, Reinhard S, Koch C, Oberhänsli T, Unger L. Selected microRNAs as biomarkers in sarcoid-affected horses under immunotherapy with a mistletoe extract. J Vet Diagn Invest 2026 Jan;38(1):33-40.
    doi: 10.1177/10406387251362820pubmed: 41039872google scholar: lookup
  18. Vychodilova L, Plasil M, Futas J, Kopecka A, Molinkova D, Wijacki T, Jahn P, Knoll A, Horin P. Genetic susceptibility to sarcoid in Arabian horses: associations with MHC class II and compound MHC class I/KLRA genotypes. Vet Res Commun 2025 May 1;49(3):184.
    doi: 10.1007/s11259-025-10748-2pubmed: 40310488google scholar: lookup
  19. Labens R, Saba C, Williams J, Hollis A, Ensink J, Jose-Cunilleras E, Jordana-Garcia M, Bergvall K, Ruppin M, Condon F, Spelta C, Elce Y, De Ridder T, Morton J, McGee C, Reddell P. Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas. Equine Vet J 2026 Jan;58(1):89-104.
    doi: 10.1111/evj.14502pubmed: 40170619google scholar: lookup
  20. Sosa E, Giannitti F, Macías-Rioseco M, Colque Caro LA, Silveira CDS, García JA, Scioli MV, Morrell E, Moore DP, Chianini F, Cantón GJ. Congenital neoplasms in cattle: a literature review and multi-institutional case series. J Vet Diagn Invest 2025 Jul;37(4):559-573.
    doi: 10.1177/10406387251324512pubmed: 40070027google scholar: lookup
Subscribe to our newsletter
Join 99,780 horse owners like you who receive our email updates on horse health and nutrition.