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Archives of virology1996; 141(9); 1601-1612; doi: 10.1007/BF01718285

Survey of equine rotaviruses shows conservation of one P genotype in background of two G genotypes.

Abstract: DIG-labelled ssRNA probes were prepared from variable regions of VP4 and VP7 cognate genes, and used in hybridization assays for P and G genotyping of group A cell culture-adapted equine rotaviruses and fecal samples collected from foals with and without diarrhea. The probes confirmed known P and G serotypes of sixteen cell culture-adapted strains. From one-hundred and twenty-one rotavirus-positive samples, 83 reacted when tested for their P and G genotype specific probes. From these, 71 were found to contain G3 P12 genotypes, and 11 G14 P12 genotypes. No sample reacted with H1 or L338 P and G genotype probes. This suggests that the equine rotavirus population is conservative, containing predominantly one P genotype and two G genotypes. One isolate (26/94) whose dsRNA was visualized in an agarose gel did not react with any of the equine probes, and was found to belong to G8 and P1 genotypes. This is the fourth example of a single unique equine isolate (after H1, L338, and R-22). The remaining thirty-eight untypable field isolates had no detectable dsRNA after storage for 1 to 3 years.
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Publication Date: 1996-01-01 PubMed ID: 8893784DOI: 10.1007/BF01718285Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study analyzed the different types of rotavirus found in horses, discovering that the virus population predominantly has one P genotype and two G genotypes, providing insight into how to combat this common cause of diarrhea in young horses.

Research Overview

The research focused on the genotyping of group A equine rotaviruses, conducting hybridization assays using DIG-labelled ssRNA probes made from variable regions of VP4 and VP7 genes. The researchers examined both cell culture-adapted rotaviruses and fecal samples obtained from foals, both healthy and suffering from diarrhea.

Results

  • The probes confirmed the known P and G serotypes, both classes of antigens that allow for the classification of rotaviruses, in sixteen cell-cultured strains.
  • Of 121 rotavirus-positive samples, 83 reacted when tested with their specific P and G genotype probes.
  • From these, 71 were found to be of the G3 P12 genotypes, while 11 were of the G14 P12 genotypes.
  • No samples reacted with the H1 or L338 P and G genotype probes.

Significance of Findings

The findings suggest that the equine rotavirus population is conservative in nature, predominantly containing one P genotype (P12) and two G genotypes (G3 and G14). These insights are valuable in understanding the spread of the virus and how best to combat it.

Unique Isolate and Untypeable Isolates

  • One unique isolate was found that did not react with any of the equine probes. Upon further investigation, it was found to belong to the G8 and P1 genotypes. This is only the fourth unique equine isolate discovered, following H1, L338, and R-22.
  • Also, thirty-eight field isolates were found untypable as they had no detectable dsRNA, possibly due to degradation during storage for 1 to 3 years.

This research provides valuable insights into equine rotavirus genotypes and their distribution, which can be influential in further research and development of treatment and preventive measures.

Cite This Article

APA
Isa P, Wood AR, Netherwood T, Ciarlet M, Imagawa H, Snodgrass DR. (1996). Survey of equine rotaviruses shows conservation of one P genotype in background of two G genotypes. Arch Virol, 141(9), 1601-1612. https://doi.org/10.1007/BF01718285

Publication

Archives of virology
ISSN: 0304-8608
NlmUniqueID: 7506870
Country: Austria
Language: English
Volume: 141
Issue: 9
Pages: 1601-1612

Researcher Affiliations

Isa, P
  • Moredun Research Institute, Edinburgh, U.K.
Wood, A R
    Netherwood, T
      Ciarlet, M
        Imagawa, H
          Snodgrass, D R

            MeSH Terms

            • Animals
            • Antigens, Viral
            • Blotting, Northern / methods
            • Blotting, Southern / methods
            • Capsid / genetics
            • Capsid Proteins
            • Cell Line
            • Genotype
            • Horse Diseases
            • Horses
            • RNA Probes
            • Rotavirus / classification
            • Rotavirus / genetics
            • Rotavirus / isolation & purification
            • Rotavirus Infections / veterinary
            • Rotavirus Infections / virology
            • Sensitivity and Specificity

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