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Theriogenology2012; 78(3); 495-501; doi: 10.1016/j.theriogenology.2012.02.028

Susceptibility to persistent breeding-induced endometritis in the mare: relationship to endometrial biopsy score and age, and variations between seasons.

Abstract: The objectives were to: (1) investigate the associations of age and endometrial biopsy score with uterine fluid retention after insemination; and (2) determine if a strict classification of susceptibility to persistent breeding-induced endometritis (PBIE) based on biopsy score, endometrial cytology, and fluid retention after inseminations, is consistent over subsequent breeding seasons. In Experiment 1, 57 mares were inseminated with 10(9) freeze-killed sperm during estrus and evaluated for uterine fluid retention 48 h and 96 h after insemination. Comparisons were made between fluid retention and biopsy score or age. In Experiment 2, a subset of 14 mares was classified for susceptibility to persistent breeding-induced endometritis in two subsequent breeding seasons. Biopsy score and age were associated with fluid retention (P < 0.001). In addition, age was related to biopsy score (P < 0.001). Of the mares examined for susceptibility, 36% (5 of 14) changed status during subsequent seasons. Three mares changed to a more severe classification (intermediate to susceptible, or resistant to intermediate), whereas two mares changed to a less severe classification (susceptible to intermediate).
Copyright © 2012 Elsevier Inc. All rights reserved.
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Publication Date: 2012-04-10 PubMed ID: 22494681DOI: 10.1016/j.theriogenology.2012.02.028Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on the relationship between a mare’s age, endometrial biopsy score, and her susceptibility to persistent breeding-induced endometritis (PBIE). The researchers conducted two experiments to gauge these relationships and understand if the susceptibility classification is consistent over different breeding seasons.

Objective of the Study

The study aimed to achieve two main goals:

  • First, to explore the associations between a mare’s age and endometrial biopsy score with uterine fluid retention after insemination.
  • Second, to determine if the standard classification of susceptibility to Persistent Breeding-Induced Endometritis (PBIE) – a condition characterized by inflammation of the uterus lining following breeding – is consistent across different breeding seasons. This classification is based on the biopsy score, endometrial cytology (study of uterine cells), and fluid retention after insemination.

Overview of the Study

The study comprised two experiments:

  • In the first experiment, 57 mares were inseminated with freeze-killed sperm during their estrus (period of sexual receptivity) and evaluated for uterine fluid retention 48 hours and 96 hours after insemination. The researchers examined the relationships between fluid retention and either biopsy score or age.
  • In the second experiment, 14 mares from the original 57 were categorized based on their susceptibility to PBIE across two consecutive breeding seasons.

Findings of the Study

  • The results indicated a strong correlation between biopsy score, age, and fluid retention. The older the mare, the higher her biopsy score tended to be, and the more uterine fluid she tended to retain post-insemination.
  • The study also found that age and biopsy score were related.
  • Further, it was observed that the mares’ PBIE susceptibility status might shift between seasons. Of the 14 mares re-examined in the second season, five (or 36%) showed a change in their PBIE susceptibility status. Three of these mares saw an increase in their susceptibility (from intermediate to susceptible, or resistant to intermediate). Conversely, two mares’ classification changed to a less severe PBIE susceptibility status.

Through these experiments, the study sheds light on the relationships between endometrial health, fluid retention post-breeding, and the mare’s age, while questioning the consistency of PBIE susceptibility classification across different breeding seasons.

Cite This Article

APA
Woodward EM, Christoffersen M, Campos J, Squires EL, Troedsson MH. (2012). Susceptibility to persistent breeding-induced endometritis in the mare: relationship to endometrial biopsy score and age, and variations between seasons. Theriogenology, 78(3), 495-501. https://doi.org/10.1016/j.theriogenology.2012.02.028

Publication

Theriogenology
ISSN: 1879-3231
NlmUniqueID: 0421510
Country: United States
Language: English
Volume: 78
Issue: 3
Pages: 495-501

Researcher Affiliations

Woodward, E M
  • The Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA. elizabeth.woodward@uky.edu
Christoffersen, M
    Campos, J
      Squires, E L
        Troedsson, M H T

          MeSH Terms

          • Age Factors
          • Animals
          • Biopsy / veterinary
          • Body Fluids
          • Breeding
          • Disease Susceptibility / veterinary
          • Endometritis / etiology
          • Endometritis / pathology
          • Endometritis / veterinary
          • Endometrium / pathology
          • Female
          • Horse Diseases / etiology
          • Horse Diseases / pathology
          • Horses
          • Insemination, Artificial / adverse effects
          • Insemination, Artificial / veterinary
          • Seasons

          Citations

          This article has been cited 18 times.
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          18. Donato GG, Necchi D, Vandaele H, Vita ME, Bertero A, Vincenti L, Nervo T. Influence of Intrauterine Fluid Detection, Number of Transfers and Age of the Recipient on Pregnancy Rate and Early Embryonic Loss in a Commercial Embryo Transfer Program. Animals (Basel) 2023 May 29;13(11).
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