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Home / Equine Research Bank / J Vet Intern Med / Synovial fluid D-dimer concentration in foals with septic jo...
Journal of veterinary internal medicine2011; 25(5); 1113-1117; doi: 10.1111/j.1939-1676.2011.0758.x

Synovial fluid D-dimer concentration in foals with septic joint disease.

Abstract: Increased synovial fibrinolytic activity (detected by increases in synovial D-Dimer concentrations) has been observed in different joint diseases in humans and adult horses, presumably in order to minimize fibrin deposition within the joint and thus avoid its detrimental effects. Objective: To investigate fibrinolytic pathway activation in joint sepsis in foals by measuring synovial D-Dimer concentrations. Methods: Eighteen septic foals with septic joints, 9 septic foals without septic joints, 9 systemically healthy foals with septic joint, and 3 controls are included. Methods: Prospective observational clinical study of foals admitted for septic arthritis. Synovial D-Dimer concentration and routine synovial fluid analysis were performed. Diagnosis of joint sepsis was made whenever synovial total nucleated cell count was >30,000 cells/μL, synovial total protein >4 g/dL, and neutrophil percentage of >80%, or synovial fluid culture resulted positive. Results were compared among groups by general lineal models. Results: Synovial D-Dimer concentration was significantly (P < .001) higher in the foals with septic joints compared with foals without joint disease (P < .001). Conclusions: Septic joint disease is associated with a marked increase of synovial D-Dimer concentration (marked activation of the fibrinolytic activity) within the affected joint. Although further studies are needed, the measurement of synovial D-Dimer concentration may be considered a complementary diagnostic marker of septic joint disease.
Copyright © 2011 by the American College of Veterinary Internal Medicine.
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Publication Date: 2011-07-22 PubMed ID: 21781162DOI: 10.1111/j.1939-1676.2011.0758.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study centers on the investigation of fibrinolytic pathway activation in joint sepsis in foals by tracking synovial D-Dimer concentrations. The research reveals a significant increase of synovial D-Dimer concentration, indicating increased fibrinolytic activity in foals with septic joints, which may potentially make D-Dimer measurement a complementary diagnostic tool.

Objective and Methodology

  • The main objective of this study was to investigate the activation of the fibrinolytic pathway in septic joint disease in foals, which was accomplished by measuring synovial D-Dimer concentrations.
  • The researchers conducted a prospective observational clinical study, involving 18 septic foals with septic joints, 9 septic foals without septic joints, 9 systemically healthy foals with septic joint, and 3 controls.
  • Data was collected through the measurement of synovial D-Dimer concentration and routine synovial fluid analysis. Diagnosis of joint sepsis was made based on certain conditions, such as synovial total nucleated cell count being >30,000 cells/μL, synovial total protein being >4 g/dL, neutrophil percentage of >80%, or if synovial fluid culture tested positive.
  • The results were statistically analyzed and compared among the groups using general linear models.

Findings

  • The study found that the synovial D-Dimer concentration was significantly higher in foals with septic joints compared to those without joint disease.
  • These results point towards a marked activation of the fibrinolytic activity within the afflicted joint, as suggested by the elevated synovial D-Dimer concentration.

Conclusions

  • The findings from this study suggest a strong association between septic joint disease and a marked increase in synovial D-Dimer concentration.
  • Though further research is needed, the results from this study indicate that the measurement of synovial D-Dimer concentration may be used as a complementary diagnostic marker for septic joint disease in foals.

Cite This Article

APA
Ribera T, Monreal L, Armengou L, Ríos J, Prades M. (2011). Synovial fluid D-dimer concentration in foals with septic joint disease. J Vet Intern Med, 25(5), 1113-1117. https://doi.org/10.1111/j.1939-1676.2011.0758.x

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 25
Issue: 5
Pages: 1113-1117

Researcher Affiliations

Ribera, T
  • Servei de Cirurgia Equina, Universitat Autònoma de Barcelona, Barcelona, Spain. thais.ribera@uab.cat
Monreal, L
    Armengou, L
      Ríos, J
        Prades, M

          MeSH Terms

          • Animals
          • Arthritis, Infectious / physiopathology
          • Arthritis, Infectious / veterinary
          • Biomarkers / analysis
          • Case-Control Studies
          • Female
          • Fibrin Fibrinogen Degradation Products / analysis
          • Horse Diseases / physiopathology
          • Horses
          • Humans
          • Male
          • Prospective Studies
          • Synovial Fluid / chemistry
          • Synovial Fluid / cytology

          Citations

          This article has been cited 24 times.
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