Target animal safety and tolerance study of pyrantel pamoate paste (19.13% w/w pyrantel base) administered orally to horses.

This research examines the safety and effectiveness of a medication known as pyrantel pamoate paste for the treatment of tapeworm infections in horses. It specifically investigates the drug’s impact on the animals’ health and physiology when delivered at various dosage levels.

Objective and Methodology

• The goal of this research was to assess both the safety and tolerance of pyrantel pamoate paste (19.13% w/w pyrantel base), specifically towards Anoplocephala spp, a common species of tapeworm in horses. The assessment involved delivering the medication orally at different doses (0, 1, 3, 5, and 10 times the clinical dose), on a daily basis, for six consecutive days.
• A variety of health indicators were monitored throughout the study. These included clinical symptoms, food and water consumption rates, body weight, physical examinations records, and an array of clinical pathology tests such as blood work, coagulation assessments, serum chemistry, urine and stool tests.
• The researchers also conducted complete necropsies, organ weight measuremnts, and histopathological examinations to explore any possible tissue effects of the drug administration.

Findings and Conclusion

• The research found no adverse effects or significant changes linked to the administration of the pyrantel pamoate paste in any treatment group during the daily clinical assessments of the horses. This was indicated by statistically significant changes that exhibited no consistent dose- or time-dependent pattern, leading to their classification as incidental, or coincidental.
• Analysis of macroscopic and microscopic tissue didn’t show any deleterious effects of the drug at any dose in either sex of horses.
• The study determined the no-observed-effect-level (NOEL) for pyrantel pamoate paste, when delivered orally to horses once daily for six consecutive days, to be 132 mg/kg/day.
• The results of this research suggest that pyrantel pamoate paste (19.13% w/w pyrantel base) can be safely administered orally to horses at a dose of 13.2 mg of pyrantel base/kg for the treatment of Anoplocephala infestations without causing severe health issues or significant side effects.