Temporal effects of halothane and isoflurane in laterally recumbent ventilated male horses.
Abstract: Cardiopulmonary function was monitored in 6 non-medicated, healthy male horses, anesthetized with halothane or isoflurane in O2 at a constant dose (1.2 times the minimum alveolar concentration). Horses were exposed once to each anesthetic agent, and a minimum of 2 weeks separated anesthetic exposures. All horses were studied in left lateral recumbency, and ventilation was mechanically controlled to induce a PaCO2 of 35 to 45 mm of Hg and an inspiratory peak airway pressure of 18 to 22 cm of H2O. After 1 hour of horse preparation, constant conditions were begun. With duration of anesthesia, cardiac output increased (P less than 0.05) with both anesthetic agents, because of an increase in stroke volume (P less than 0.05). Heart rate did not change from initial values with either agent. Mean arterial blood pressure also increased (P less than 0.05) with both agents. With both anesthetics, respiratory rate (P less than 0.05) was increased progressively to maintain acceptable PaCO2 values. Arterial O2 tension did not change with time.
Publication Date: 1987-08-01 PubMed ID: 3631716
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study involves observing the effects of two types of anesthesia, halothane and isoflurane, on the heart and lung functions of healthy male horses during a period of induced ventilation.
Research Background
- The aim of the study is to understand the effects of halothane and isoflurane on the cardiopulmonary function of horses.
- The test subjects are six healthy male horses that are not under any medication.
- Each horse was exposed to both types of anesthetic agents with at least a two-week interval in between exposures.
Research Methodology
- The horses are kept in left lateral recumbency, a sideways position and their breathing is mechanically controlled.
- The goal is to maintain a PaCO2 (partial pressure of carbon dioxide in arterial blood) of 35 to 45mm of Hg and an inspiratory peak airway pressure of 18 to 22cm of H2O, parameters that ensure the effective delivery of oxygen and removal of carbon dioxide from their bodies.
- The anesthesia is kept at a constant dose, set at 1.2 times the minimum alveolar concentration (MAC), which is a standard measure used in anesthetic practice.
Research Findings
- The data indicate that over the duration of anesthesia, cardiac output increase under both anesthetic agents.
- This is due to an increased stroke volume, or volume of blood pumped per heartbeat, while the heart rate remains unchanged.
- The mean arterial blood pressure also showed an increase with both agents.
- Respiratory rate also increased progressively, necessary to maintain acceptable PaCO2 levels.
- However, arterial oxygen tension, a measure of the oxygen level in the blood, did not change over time.
Conclusion
- This research provides valuable insights into the effects of halothane and isoflurane anesthesia on horse cardiopulmonary function.
- The findings are particularly pertinent for veterinary procedures involving anesthetized horses and can aid in improving anesthesia protocols and horse health outcomes.
Cite This Article
APA
Dunlop CI, Steffey EP, Miller MF, Woliner MJ.
(1987).
Temporal effects of halothane and isoflurane in laterally recumbent ventilated male horses.
Am J Vet Res, 48(8), 1250-1255.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Blood Circulation / drug effects
- Blood Gas Analysis / veterinary
- Halothane / pharmacology
- Hemodynamics / drug effects
- Horses / physiology
- Isoflurane / pharmacology
- Male
- Posture
- Pulmonary Gas Exchange
- Respiration / drug effects
- Respiration, Artificial
Citations
This article has been cited 2 times.- Brosnan RJ. Inhaled anesthetics in horses. Vet Clin North Am Equine Pract 2013 Apr;29(1):69-87.
- Khanna AK, McDonell WN, Dyson DH, Taylor PM. Cardiopulmonary effects of hypercapnia during controlled intermittent positive pressure ventilation in the horse. Can J Vet Res 1995 Jul;59(3):213-21.
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