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Acta veterinaria Scandinavica1998; 39(1); 25-33; doi: 10.1186/BF03547804

Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity.

Abstract: Eighty Standardbred horses, originating from 5 training campuses, with decreased athletic performance in association with symptoms such as intermittent fever and mild pharyngitis were examined. As control animals, 10 horses from a stable with normally performing horses were used. Virus isolation and clinico-chemical and serological tests were performed. Lymphocyte proliferation tests were carried out to evaluate the capacity of the cell-mediated immunity. In addition, a bioassay for equine type I interferon, as a marker for early viral infections, was established. No specific microbe could be linked to these symptoms, but there was a temporary suppression of the cell-mediated immunity, which might be explained by the serological evidence of an EHV-2 and/or rhinovirus infection. Åttio varmblodiga tråvare med nedsatt prestationsförmåga från 5 olika träningsstallar undersöktes. Förutom försämrad prestation uppvisade flertalet av hästarna intermittent feber och lindrig faryngit. Många var även matta och krustösa i hårremmen. Kontrollgruppen bestod av 10 normalpresterande tävlingshästar från ett annat träningsstall. Virusisolering, serologi, hematologi samt lymfocytproliferationstester, som speglar det cellmedierade immunsystemet, utfördes. Som en markör för en tidig viral infektion etablerades en bioassay för ekvint interferon typ 1. Ingen specifik mikrob kunde knytas till den nedsatta prestationsförmågan, däremot kunde en temporär suppression av det cellmedierade immunsystemet beläggas. Möjligen kan denna immunosuppression associeras till de serologiska indikationerna på EHV-2 och/eller rhinovirus infektion. Samtliga hästar med nedsatt kapacitet tävlade och tränade på sin förväntade förmåga efter en konvalescens på 6 till 10 månader.
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Publication Date: 1998-05-21 PubMed ID: 9592943PubMed Central: PMC8050687DOI: 10.1186/BF03547804Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on studying 80 standardbred horses with reduced athletic performance due to symptoms like intermittent fever and mild pharyngitis. They discovered a temporary suppression of cell-mediated immunity within these horses, possibly due to EHV-2 and/or rhinovirus infection.

Study Participants and Methods

  • The study was conducted on 80 Standardbred horses from 5 different training campuses who were experiencing decreased athletic performance. Common symptoms among these horses were intermittent fever and mild pharyngitis.
  • These horses were compared against a control group consisting of 10 horses from a different stable, who were performing normally.
  • The researchers used a variety of methods to evaluate the health of these horses, including virus isolation, clinico-chemical tests, serological tests, and lymphocyte proliferation tests. The latter was performed to evaluate the capacity of the horses’ cell-mediated immunity.
  • An additional marker, a bioassay for equine type I interferon, was established as an indicator for early viral infections.

Research Findings

  • The researchers found that there was a temporary suppression in cell-mediated immunity among the standardbred horses with decreased athletic performance. The reason behind this suppression, however, was unclear, as no specific microbe could be conclusively linked to these symptoms.
  • This suppression of immunity might be attributed to an EHV-2 and/or rhinovirus infection, as shown by serological evidence.
  • All the horses with decreased athletic capacity returned to their expected performance levels following a convalescence period of between 6 to 10 months. This suggests that the suppression of cell-mediated immunity, and related underperformance, was temporary.

Cite This Article

APA
Jensen-Waern M, Persson SG, Nordengrahn A, Mérza M, Fossum C. (1998). Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity. Acta Vet Scand, 39(1), 25-33. https://doi.org/10.1186/BF03547804

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 39
Issue: 1
Pages: 25-33

Researcher Affiliations

Jensen-Waern, M
  • Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala, Sweden. Marianne.Jensen-Waern@kirmed.slu.se
Persson, S G
    Nordengrahn, A
      Mérza, M
        Fossum, C

          MeSH Terms

          • Animals
          • Antibodies, Viral / blood
          • Fever / immunology
          • Fever / veterinary
          • Horse Diseases
          • Horses / immunology
          • Immunity, Cellular
          • Interferon-alpha / biosynthesis
          • Lymphocyte Activation
          • Lymphocytes / immunology
          • Pharyngitis / immunology
          • Pharyngitis / veterinary
          • Physical Conditioning, Animal
          • Picornaviridae
          • Picornaviridae Infections / blood
          • Picornaviridae Infections / immunology
          • Picornaviridae Infections / veterinary
          • Running

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          Citations

          This article has been cited 3 times.
          1. Christidis N, Ghafouri B, Larsson A, Palstam A, Mannerkorpi K, Bileviciute-Ljungar I, Löfgren M, Bjersing J, Kosek E, Gerdle B, Ernberg M. Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle--A Microdialysis Study. PLoS One 2015;10(12):e0143856.
            doi: 10.1371/journal.pone.0143856pubmed: 26624891google scholar: lookup
          2. Detournay O, Morrison DA, Wagner B, Zarnegar B, Wattrang E. Genomic analysis and mRNA expression of equine type I interferon genes. J Interferon Cytokine Res 2013 Dec;33(12):746-59.
            doi: 10.1089/jir.2012.0130pubmed: 23772953google scholar: lookup
          3. Camarda G, Spinetti G, Bernardini G, Mair C, Davis-Poynter N, Capogrossi MC, Napolitano M. The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor. J Virol 1999 Dec;73(12):9843-8.
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