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Home / Equine Research Bank / Acta Vet Scand / Temporary suppression of cell-mediated immunity in standardb...
Acta veterinaria Scandinavica1998; 39(1); 25-33; doi: 10.1186/BF03547804

Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity.

Abstract: Eighty Standardbred horses, originating from 5 training campuses, with decreased athletic performance in association with symptoms such as intermittent fever and mild pharyngitis were examined. As control animals, 10 horses from a stable with normally performing horses were used. Virus isolation and clinico-chemical and serological tests were performed. Lymphocyte proliferation tests were carried out to evaluate the capacity of the cell-mediated immunity. In addition, a bioassay for equine type I interferon, as a marker for early viral infections, was established. No specific microbe could be linked to these symptoms, but there was a temporary suppression of the cell-mediated immunity, which might be explained by the serological evidence of an EHV-2 and/or rhinovirus infection. Åttio varmblodiga tråvare med nedsatt prestationsförmåga från 5 olika träningsstallar undersöktes. Förutom försämrad prestation uppvisade flertalet av hästarna intermittent feber och lindrig faryngit. Många var även matta och krustösa i hårremmen. Kontrollgruppen bestod av 10 normalpresterande tävlingshästar från ett annat träningsstall. Virusisolering, serologi, hematologi samt lymfocytproliferationstester, som speglar det cellmedierade immunsystemet, utfördes. Som en markör för en tidig viral infektion etablerades en bioassay för ekvint interferon typ 1. Ingen specifik mikrob kunde knytas till den nedsatta prestationsförmågan, däremot kunde en temporär suppression av det cellmedierade immunsystemet beläggas. Möjligen kan denna immunosuppression associeras till de serologiska indikationerna på EHV-2 och/eller rhinovirus infektion. Samtliga hästar med nedsatt kapacitet tävlade och tränade på sin förväntade förmåga efter en konvalescens på 6 till 10 månader.
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Publication Date: 1998-05-21 PubMed ID: 9592943PubMed Central: PMC8050687DOI: 10.1186/BF03547804Google Scholar: Lookup
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  • Journal Article
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on studying 80 standardbred horses with reduced athletic performance due to symptoms like intermittent fever and mild pharyngitis. They discovered a temporary suppression of cell-mediated immunity within these horses, possibly due to EHV-2 and/or rhinovirus infection.

Study Participants and Methods

  • The study was conducted on 80 Standardbred horses from 5 different training campuses who were experiencing decreased athletic performance. Common symptoms among these horses were intermittent fever and mild pharyngitis.
  • These horses were compared against a control group consisting of 10 horses from a different stable, who were performing normally.
  • The researchers used a variety of methods to evaluate the health of these horses, including virus isolation, clinico-chemical tests, serological tests, and lymphocyte proliferation tests. The latter was performed to evaluate the capacity of the horses’ cell-mediated immunity.
  • An additional marker, a bioassay for equine type I interferon, was established as an indicator for early viral infections.

Research Findings

  • The researchers found that there was a temporary suppression in cell-mediated immunity among the standardbred horses with decreased athletic performance. The reason behind this suppression, however, was unclear, as no specific microbe could be conclusively linked to these symptoms.
  • This suppression of immunity might be attributed to an EHV-2 and/or rhinovirus infection, as shown by serological evidence.
  • All the horses with decreased athletic capacity returned to their expected performance levels following a convalescence period of between 6 to 10 months. This suggests that the suppression of cell-mediated immunity, and related underperformance, was temporary.

Cite This Article

APA
Jensen-Waern M, Persson SG, Nordengrahn A, Mérza M, Fossum C. (1998). Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity. Acta Vet Scand, 39(1), 25-33. https://doi.org/10.1186/BF03547804

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 39
Issue: 1
Pages: 25-33

Researcher Affiliations

Jensen-Waern, M
  • Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala, Sweden. Marianne.Jensen-Waern@kirmed.slu.se
Persson, S G
    Nordengrahn, A
      Mérza, M
        Fossum, C

          MeSH Terms

          • Animals
          • Antibodies, Viral / blood
          • Fever / immunology
          • Fever / veterinary
          • Horse Diseases
          • Horses / immunology
          • Immunity, Cellular
          • Interferon-alpha / biosynthesis
          • Lymphocyte Activation
          • Lymphocytes / immunology
          • Pharyngitis / immunology
          • Pharyngitis / veterinary
          • Physical Conditioning, Animal
          • Picornaviridae
          • Picornaviridae Infections / blood
          • Picornaviridae Infections / immunology
          • Picornaviridae Infections / veterinary
          • Running

          References

          This article includes 29 references
          1. GP A, JT B. Molecular epizootiology, pathogenesis and prophylaxis of equine herpesvirus-1 infection.. Prog.vet. Microbiol. Immunol. 1986;128:1–54.
          2. Artursson K, Wallgren P, Alm GV. Appearance of interferon-alpha in serum and signs of reduced immune function in pigs after transport and installation in a fattening farm.. Vet Immunol Immunopathol 1989 Dec;23(3-4):345-53.
            pubmed: 2629198doi: 10.1016/0165-2427(89)90146-3google scholar: lookup
          3. AL B, JG M. Changes in skin sensi tiveness to tuberculin during epidemic influenza.. Am. Rev. Tuberculosis. 1919;3:166–167.
          4. Bryans JT. Herpesviral diseases affecting reproduction in the horse.. Vet Clin North Am Large Anim Pract 1980 Nov;2(2):303-12.
            pubmed: 6262988doi: 10.1016/s0196-9846(17)30164-7google scholar: lookup
          5. R B. Equine rhinoviruses.. 1970; pp. 154–160.
          6. Carter JJ, Weinberg AD, Pollard A, Reeves R, Magnuson JA, Magnuson NS. Inhibition of T-lymphocyte mitogenic responses and effects on cell functions by bovine herpesvirus 1.. J Virol 1989 Apr;63(4):1525-30.
            doi: 10.1128/JVI.63.4.1525-1530.1989pmc: PMC248384pubmed: 2538643google scholar: lookup
          7. Chong YC, Duffus WP. Immune responses of specific pathogen free foals to EHV-1 infection.. Vet Microbiol 1992 Oct;32(3-4):215-28.
            doi: 10.1016/0378-1135(92)90146-Kpubmed: 1280876google scholar: lookup
          8. MD E. Energetics and Performance.. 1994; pp. 49–61.
          9. Freestone JF, Carlson GR. Muscle disorders in the horse: a retrospective study.. Equine Vet J 1991 Mar;23(2):86-90.
            doi: 10.1111/j.2042-3306.1991.tb02726.xpubmed: 1904348google scholar: lookup
          10. I G. Role of interferon in resistance to viral infections in vivo.. 1984; pp. 221–247.
          11. D H, T O, DM J, JA M. Evidence for non-specific immunosuppression during the development of immune responses to Equid Herpesvirus-1. Equine vet J. 1991; pp. 41–45.
          12. Larsson B. Increased suppressor cell activity in cattle persistently infected with bovine virus diarrhoea virus.. Zentralbl Veterinarmed B 1988 May;35(4):271-9.
            doi: 10.1111/j.1439-0450.1988.tb00497.xpubmed: 2971300google scholar: lookup
          13. Mills EL. Viral infections predisposing to bacterial infections.. Annu Rev Med 1984;35:469-79.
            doi: 10.1146/annurev.me.35.020184.002345pubmed: 6326662google scholar: lookup
          14. Morein B, Merza M. Vaccination against herpesvirus, fiction or reality?. Scand J Infect Dis Suppl 1991;80:110-8.
            pubmed: 1666442
          15. Morris EA, Seeherman HJ. Evaluation of upper respiratory tract function during strenuous exercise in racehorses.. J Am Vet Med Assoc 1990 Feb 1;196(3):431-8.
            pubmed: 2298672
          16. Pálfi V, Belák S, Molnár T. Isolation of equine herpesvirus type 2 from foals, showing respiratory symptoms.. Zentralbl Veterinarmed B 1978 Mar;25(2):165-7.
            pubmed: 207057doi: 10.1111/j.1439-0450.1978.tb00737.xgoogle scholar: lookup
          17. Persson S. On blood volume and working capacity in horses. Studies of methodology and physiological and pathological variations.. Acta Vet Scand 1967;:Suppl 19:9-189.
            pubmed: 4863601
          18. SGP P. Blood volume, state of training, and working capacity of race horses. Equine vet J. 1968; pp. 52–62.
          19. G P, JB K. Studies on equine respiratory virus.. Vet. Ree. 1962;74:967–970.
          20. Thomson GR, Mumford JA. In vitro stimulation of foal lymphocytes with equid herpesvirus 1.. Res Vet Sci 1977 May;22(3):347-52.
            pubmed: 195321
          21. A V, A B, DE B. The use of enzyme-linked immunosorbent assay in the serology of viral and parasitic diseases.. Scand. J. Immunol. 1978;8:123–129.
          22. Wainberg MA, Portnoy JD, Clecner B, Hubschman S, Lagacé-Simard J, Rabinovitch N, Remer Z, Mendelson J. Viral inhibition of lymphocyte proliferative responsiveness in patients suffering from recurrent lesions caused by herpes simplex virus.. J Infect Dis 1985 Sep;152(3):441-8.
            doi: 10.1093/infdis/152.3.441pubmed: 2993440google scholar: lookup
          23. Wallgren P, Artursson K, Fossum C, Alm GV. Incidence of infections in pigs bred for slaughter revealed by elevated serum levels of interferon and development of antibodies to Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae.. Zentralbl Veterinarmed B 1993 Feb;40(1):1-12.
            pubmed: 8456565doi: 10.1111/j.1439-0450.1993.tb00102.xgoogle scholar: lookup
          24. Wilks CR, Coggins L. Immunity to equine herpesvirus type 1 (rhinopneumonitis): in vitro lymphocyte response.. Am J Vet Res 1976 May;37(5):486-92.
            pubmed: 179451
          25. WILSON JC, BRYANS JT, DOLL ER, TUDOR L. ISOLATION OF A NEWLY IDENTIFIED EQUINE RESPIRATORY VIRUS.. Cornell Vet 1965 Jul;55:425-31.
            pubmed: 14343834
          26. G W, RM G, H-J R. Latent Herpes Virus Infections in Veterinary Medicine.. 1984.
          27. Wood JL, Burrell MH, Roberts CA, Chanter N, Shaw Y. Streptococci and Pasteurella spp. associated with disease of the equine lower respiratory tract.. Equine Vet J 1993 Jul;25(4):314-8.
            doi: 10.1111/j.2042-3306.1993.tb02970.xpubmed: 8354218google scholar: lookup
          28. JLN W, N C, R S, JA M. The epidemiology of outbreaks of respiratory disease and poor performance in racing Thoroughbred horses.. 1994.
          29. Yilma T, McGuire TC, Perryman LE. Preliminary characterization of equine interferons and their antiviral activities on bovine, ovine, and human cells.. J Interferon Res 1982;2(3):363-70.
            doi: 10.1089/jir.1982.2.363pubmed: 6182253google scholar: lookup

          Citations

          This article has been cited 3 times.
          1. Christidis N, Ghafouri B, Larsson A, Palstam A, Mannerkorpi K, Bileviciute-Ljungar I, Löfgren M, Bjersing J, Kosek E, Gerdle B, Ernberg M. Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle--A Microdialysis Study.. PLoS One 2015;10(12):e0143856.
            doi: 10.1371/journal.pone.0143856pubmed: 26624891google scholar: lookup
          2. Detournay O, Morrison DA, Wagner B, Zarnegar B, Wattrang E. Genomic analysis and mRNA expression of equine type I interferon genes.. J Interferon Cytokine Res 2013 Dec;33(12):746-59.
            doi: 10.1089/jir.2012.0130pubmed: 23772953google scholar: lookup
          3. Camarda G, Spinetti G, Bernardini G, Mair C, Davis-Poynter N, Capogrossi MC, Napolitano M. The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.. J Virol 1999 Dec;73(12):9843-8.
            doi: 10.1128/JVI.73.12.9843-9848.1999pubmed: 10559296google scholar: lookup
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