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The American journal of tropical medicine and hygiene1979; 28(2); 329-334; doi: 10.4269/ajtmh.1979.28.329

Ten clinical cases of human infection with venezuelan equine encephalomyelitis virus, subtype I-D.

Abstract: The clinical and laboratory findings in ten humans infected with Venezuelan equine encephalitis virus, subtype I-D, are described in this report. Clinical and laboratory data indicate that, in contrast to equine infections, human infection with these enzootic virus strains (I-D) is similar to human infection with epizootic strains (I-ABC). In most cases there was an abrupt onset of fever, muscle pain, and vomiting. Virus was recovered from sera obtained during the first 3 days of illness. Lymphopenia occurred in all patients, and neutropenia occurred in three. No sequelae of these infections were apparent.
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Publication Date: 1979-03-01 PubMed ID: 222156DOI: 10.4269/ajtmh.1979.28.329Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the symptoms and laboratory results of ten patients infected with the Venezuelan equine encephalitis virus, subtype I-D.

Overview of Research

Conducted on 10 human patients and based on the assessment of clinical as well as laboratory data, this research focusses on detailing the effects and implications of infection caused by a subtype of Venezuelan equine encephalitis virus (VEEV), specifically subtype I-D.

Findings on Human Infection

  • The infection in humans shows similar symptoms as those infected with other strains of the same virus, mainly the epizootic strains; namely subtype I-ABC.
  • Symptoms observed in patients infected with subtype I-D included fever, muscle pain, and vomiting, which tend to abruptly appear at the onset of the infection.
  • These symptoms were observed in most cases, indicating a common pattern in the effect of the infection among different patients.

Laboratory Findings

  • Virus presence was confirmed through sera obtained from the infected patients during the first three days of illness. However, the paper does not detail the methods used in the virus detection process.
  • All patients exhibited lymphopenia, which is a condition characterized by abnormally low levels of lymphocytes in the blood. Lymphocytes are crucial for the body’s immune response, suggesting that the infection significantly impacts the immune system.
  • Three out of the ten patients also developed neutropenia, another condition that involves a decrease in a specific type of white blood cell (neutrophils), also hinting at interference with the body’s immune response.

Long-term Effects and Conclusion

  • Interestingly, the research indicates that no sequelae, or subsequent health complications, were observed to be directly caused by these infections, suggesting that despite its acute manifestations, the virus may not contribute to long-term health issues.
  • Overall, the research deepens the understanding of human infection by the Venezuelan equine encephalitis virus, subtype I-D, mapping out the primary inflammatory responses and the virus’ influence on the immune system, while also establishing its symptom pattern.

Cite This Article

APA
Dietz WH, Peralta PH, Johnson KM. (1979). Ten clinical cases of human infection with venezuelan equine encephalomyelitis virus, subtype I-D. Am J Trop Med Hyg, 28(2), 329-334. https://doi.org/10.4269/ajtmh.1979.28.329

Publication

The American journal of tropical medicine and hygiene
ISSN: 0002-9637
NlmUniqueID: 0370507
Country: United States
Language: English
Volume: 28
Issue: 2
Pages: 329-334

Researcher Affiliations

Dietz, W H
    Peralta, P H
      Johnson, K M

        MeSH Terms

        • Adolescent
        • Adult
        • Encephalomyelitis, Equine / pathology
        • Encephalomyelitis, Venezuelan Equine / blood
        • Encephalomyelitis, Venezuelan Equine / pathology
        • Enterovirus / isolation & purification
        • Enterovirus / pathogenicity
        • Female
        • Humans
        • Male
        • Middle Aged

        Citations

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