Analyze Diet
Immunology1962; 5(4); 511-521;

The alexination and conglutination reactions. The reactions between sensitized erythrocytes and horse complement and between alexinated erythrocytes and conglutinin.

Abstract: A method is described for the quantitative measurement of the reactions between sensitized cells and horse complement and between alexinated cells and conglutinin. The method is laborious but its application has allowed the determination of the optimal times of the reactions at various temperatures. The results obtained in these experiments indicate that the alexinated configuration with which conglutinin and immuno-conglutinin react is not one of the recognized intermediates formed during the process of immune haemolysis.
Publication Date: 1962-07-01 PubMed ID: 13956528PubMed Central: PMC1424077
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the reactions between sensitized cells and horse complement, as well as reactions between alexinated cells and conglutinin, providing a method for their quantitative measurement. It determines optimal times for these reactions at different temperatures and indicates that the alexinated configuration interacting with conglutinin and immuno-conglutinin is not a recognized intermediate in the immune haemolysis process.

Quantitative Measurement Method of Reactions

  • The study outlines a detailed method for quantitatively measuring the reactions between sensitized erythrocytes (red blood cells) and horse complement and between alexinated erythrocytes and conglutinin. Although the method is described as labor-intensive, it is presented as a crucial tool in understanding these complex interactions.

Determination of Optimal Reaction Times

  • Through the application of this method, optimal times of reactions at various temperatures were determined. This is a significant aspect of the research as it could potentially influence the efficiency and effectiveness of these reactions, which could carry vital implications for future research.

Alexinated Configuration Interaction

  • The findings from the research indicate that the alexinated configuration with which conglutinin and immuno-conglutinin react is not one of the well-recognized intermediates formed during the process of immune haemolysis. Immune haemolysis is a process where the immune system leads to the rupture or destruction of red blood cells.
  • This information challenges current understanding within the field and suggests that there might be other complex and as yet unrecognized configurations involved in this process.

Cite This Article

APA
INGRAM DG. (1962). The alexination and conglutination reactions. The reactions between sensitized erythrocytes and horse complement and between alexinated erythrocytes and conglutinin. Immunology, 5(4), 511-521.

Publication

ISSN: 0019-2805
NlmUniqueID: 0374672
Country: England
Language: English
Volume: 5
Issue: 4
Pages: 511-521

Researcher Affiliations

INGRAM, D G

    MeSH Terms

    • Animals
    • Collectins
    • Complement Fixation Tests
    • Complement System Proteins
    • Erythrocytes
    • Horses
    • Serum Globulins

    References

    This article includes 4 references
    1. RICE CE. A consideration of the components concerned in the conglutinating activities of certain complements.. J Immunol 1953 Jun;70(6):497-502.
      pubmed: 13069711
    2. PILLEMER L, BLUM L, LEPOW IH, ROSS OA, TODD EW, WARDLAW AC. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.. Science 1954 Aug 20;120(3112):279-85.
      pubmed: 13186838doi: 10.1126/science.120.3112.279google scholar: lookup
    3. MAYER MM, LEVINE L, RAPP HJ, MARUCCI AA. Kinetic studies on immune hemolysis. VII. Decay of EAC'1, 4, 2, fixation of C'3, and other factors influencing the hemolytic action of complement.. J Immunol 1954 Dec;73(6):443-54.
      pubmed: 13212068
    4. LEON MA, NORDEN A. Kinetics of equine complement.. J Immunol 1959 Jul;83(1):99-104.
      pubmed: 13665018

    Citations

    This article has been cited 1 times.
    1. Lachmann PJ, Liske R. The preparation and properties of alexinated intermediates that react with conglutinin. II. Equine, rabbit and human complement. Immunology 1966 Sep;11(3):255-62.
      pubmed: 5922093