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Veterinary anaesthesia and analgesia2009; 37(1); 25-34; doi: 10.1111/j.1467-2995.2009.00507.x

The bispectral index during recovery from halothane and sevoflurane anaesthesia in horses.

Abstract: To record the bispectral index (BIS) when horses moved during either halothane or sevoflurane anaesthesia and when they made volitional movements during recovery from these anaesthetics. Methods: Randomized prospective clinical study. Methods: Twenty-five client-owned horses undergoing surgery aged 8.8 (+/- 5.3; 1-19) years (mean +/- SD; range). Methods: Baseline BIS values were recorded before pre-anaesthetic medication (BIS(B)) and during anaesthesia (BIS(A)) maintained with halothane (group H; n = 12) or sevoflurane (group S; n =13) at approximately 0.8-0.9 x minimum alveolar concentrations (MAC). Bispectral indices were recorded during the surgery when unexpected movement occurred (BIS(MA)), during recovery when the first movement convincingly associated with consciousness was observed (BIS(M1)) and once sternal recumbency was achieved (BIS(ST)). Results: No significant difference in BIS(M1) was found between halothane- (85 +/- 7; 75-93) and sevoflurane- (87 +/- 10; 70-98) anaesthetized horses although BIS(A) was significantly (p = 0.0002) lower in group S (62 +/- 7; 53-72) than group H (74 +/- 7; 60-84). Differences between BIS(M1) and BIS(A) were significant in sevoflurane (p = 0.00001) and halothane recipients (p = 0.002) but were greater in group S (25 +/- 9; 4-38) compared with group H (12 +/- 10; -9-25). In six of eight horses, BIS(MA) values ranged between those recorded during anaesthesia and at first movement. Conclusions: Bispectral indices appear to approximate levels of unconsciousness, suggesting that monitoring the BIS may assist equine anaesthesia. However, it does not predict intra-operative movement.
Publication Date: 2009-12-19 PubMed ID: 20017816DOI: 10.1111/j.1467-2995.2009.00507.xGoogle Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial

Summary

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This study investigates the use of the bispectral index (BIS) for monitoring horse consciousness during recovery from two different types of anaesthesia, halothane and sevoflurane. It also considers the association of BIS with unexpected movement during surgery and consciousness-related movement during recovery.

Research Methodology

  • 25 horses were included in this randomized prospective clinical study. These horses were undergoing surgery, aged between 1 to 19 years, with an average age of 8.8 years.
  • The horses were classified into two groups, one group to receive halothane anaesthesia (n = 12) and the other to receive sevoflurane (n = 13), with BIS values recorded at several stages during the process.
  • Baseline BIS values were noted before the administration of pre-anaesthetic medication. Furthermore, BIS values were also recorded during anaesthesia, during surgery if any unexpected movement occurred, during recovery at the time of the first consciousness-linked movement, and once sternal recumbency (lying down on the chest) was achieved.

Research Findings

  • No significant difference was found in BIS scores at the first movement linked to consciousness between the two anaesthesia types, halothane and sevoflurane. However, while the horses were under anaesthesia, the BIS scores of the sevoflurane group were significantly lower than those of the halothane group.
  • The difference between anaesthesia BIS scores and those at the first consciousness-linked movement was significant and greater in the sevoflurane group compared to the halothane group.
  • In more than half of the horses, BIS values during unexpected movement during surgery were somewhere between the scores during anaesthesia and at the first movement during recovery.

Conclusions

  • The findings suggest that BIS may be a useful tool for approximating levels of unconsciousness and hence assist with equine anaesthesia monitoring. The BIS values appear to correlate with the difference in unconsciousness levels between the two types of anaesthesia used.
  • However, the BIS does not seem to effectively predict intra-operative movement, as the scores during unexpected movement tended to range between those observed during anaesthesia and conscious recovery.

Cite This Article

APA
Belda E, Blissitt KJ, Duncan JC, Laredo FG, Escobar Gil de Montes M, Clutton RE. (2009). The bispectral index during recovery from halothane and sevoflurane anaesthesia in horses. Vet Anaesth Analg, 37(1), 25-34. https://doi.org/10.1111/j.1467-2995.2009.00507.x

Publication

ISSN: 1467-2995
NlmUniqueID: 100956422
Country: United States
Language: English
Volume: 37
Issue: 1
Pages: 25-34

Researcher Affiliations

Belda, Eliseo
  • Departamento de Medicina y Cirugía Animal, Hospital Clínico Veterinario, Universidad de Murcia, Murcia, Spain.
Blissitt, Karen J
    Duncan, Juliet C
      Laredo, Francisco G
        Escobar Gil de Montes, Mayte
          Clutton, R Eddie

            MeSH Terms

            • Anesthesia Recovery Period
            • Anesthesia, Inhalation / veterinary
            • Anesthetics, Inhalation
            • Animals
            • Consciousness Monitors / veterinary
            • Female
            • Halothane
            • Horses / physiology
            • Intraoperative Care / veterinary
            • Male
            • Methyl Ethers
            • Preanesthetic Medication / veterinary
            • Sevoflurane

            Citations

            This article has been cited 6 times.
            1. Murillo C, Weng HY, Weil AB, Kreuzer M, Ko JC. Perioperative Brain Function Monitoring with Electroencephalography in Horses Anesthetized with Multimodal Balanced Anesthetic Protocol Subjected to Surgeries.. Animals (Basel) 2022 Oct 20;12(20).
              doi: 10.3390/ani12202851pubmed: 36290236google scholar: lookup
            2. Santangelo B, Robin A, Simpson K, Potier J, Guichardant M, Portier K. The Modification and Performance of a Large Animal Anesthesia Machine (Tafonius(®)) in Order to Deliver Xenon to a Horse.. Front Vet Sci 2017;4:162.
              doi: 10.3389/fvets.2017.00162pubmed: 29034250google scholar: lookup
            3. Tokushige H, Kakizaki M, Ode H, Okano A, Okada J, Kuroda T, Wakuno A, Ohta M. Validation of the bispectral index as an indicator of anesthetic depth in Thoroughbred horses anesthetized with sevoflurane.. J Equine Sci 2016;27(4):169-173.
              doi: 10.1294/jes.27.169pubmed: 27974877google scholar: lookup
            4. Tünsmeyer J, Hopster K, Kästner SB. Clinical Use of a Multivariate Electroencephalogram (Narcotrend) for Assessment of Anesthetic Depth in Horses during Isoflurane-Xylazine Anesthesia.. Front Vet Sci 2016;3:25.
              doi: 10.3389/fvets.2016.00025pubmed: 27014707google scholar: lookup
            5. Sousa JR, Ribeiro L, Silva A, Ferreira DA. Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs.. Vet Med Int 2014;2014:481460.
              doi: 10.1155/2014/481460pubmed: 24616823google scholar: lookup
            6. Romanov A, Moon RS, Wang M, Joshi S. Paradoxical increase in the bispectral index during deep anesthesia in New Zealand white rabbits.. J Am Assoc Lab Anim Sci 2014 Jan;53(1):74-80.
              pubmed: 24411783