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Home / Equine Research Bank / Animals (Basel) / The Combined Use of Triamcinolone and Platelet-Rich Plasma i...
Animals : an open access journal from MDPI2024; 14(24); doi: 10.3390/ani14243645

The Combined Use of Triamcinolone and Platelet-Rich Plasma in Equine Metacarpophalangeal Joint Osteoarthritis Treatments: An In Vivo and In Vitro Study.

Abstract: Intra-articular corticosteroids, such as triamcinolone acetonide (TA), help reduce pain related to osteoarthritis (OA), but they may impair cartilage metabolism. In contrast, platelet-rich plasma (PRP) therapy, a regenerative therapy, has shown potential to promote healing and regeneration of articular cartilage. This study investigates the effects of combining PRP with TA to treat osteoarthritis in racehorses. The study proposes that PRP injection following TA treatment could reduce side effects and improve treatment outcomes. Firstly, in the in vitro study, chondrocytes were exposed to different TA concentrations, with or without PRP. TA dramatically reduced chondrocyte viability. However, this was prevented by the addition of PRP, which also increased cell proliferation. In the in vivo study, 32 racehorses with metacarpophalangeal (MCP) joint OA were separated into two groups: one received only TA, while the other received TA followed by PRP. For both groups, there were improved flexion assessments one week following the last treatment, but by two weeks following the last treatment, only TA+PRP had improved flexion assessments. TA+PRP also had improved lameness scores two weeks after the last treatment. In conclusion, combining PRP with TA could enhance chondrocyte viability and provide a better long-term therapeutic option for treating OA in racehorses. Further trials are required to thoroughly assess this technique's safety and efficacy.
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Publication Date: 2024-12-17 PubMed ID: 39765549PubMed Central: PMC11672629DOI: 10.3390/ani14243645Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the effects of combining triamcinolone acetonide (TA), a corticosteroid medication, with platelet-rich plasma (PRP) therapy, a regenerative treatment, to improve the effects of osteoarthritis treatment in racehorses.

Objective of the Study

  • The main intent of the study was to determine if combining PRP therapy with TA would improve therapeutic outcomes in racehorses suffering from osteoarthritis in the metacarpophalangeal (MCP) joint, reducing side effects of TA alone and improving overall chondrocyte viability.

Methodology

  • Two sections of study were carried out: an in vitro study and an in vivo study.
  • In the in vitro study, chondrocytes were exposed to different concentrations of TA, with and without PRP. The researchers wanted to observe the effects of TA on chondrocyte viability and to see if adding PRP would prevent any adverse impacts and promote cell proliferation.
  • In the in vivo study, 32 racehorses with MCP joint OA were divided into two groups. One group received only TA treatment, while the other received TA followed by PRP.

Findings

  • The results of the in vitro study demonstrated that TA significantly decreased chondrocyte viability. Conversely, the addition of PRP not only prevented this reduction but also increased cell proliferation, indicating a possible regenerative effect.
  • In the in vivo study, both treatment groups showed improved flexion assessments one week following the last treatment. However, by two weeks after the last treatment, only the TA+PRP group continued to show improved flexion assessments.
  • In addition, the TA+PRP group also exhibited enhanced lameness scores two weeks following the last treatment, suggesting that the combination therapy may have superior long-term effects in OA treatment.

Conclusion and Future Scope

  • The research concluded that combining PRP with TA could enhance chondrocyte viability in OA treatment and potentially provide longer-term therapeutic results in racehorses suffering from MCP joint OA.
  • Despite promising results, further trials are required to comprehensively evaluate the safety and efficacy of this combined treatment approach.

Cite This Article

APA
Guidoni K, Chiaradia E, Pepe M, Di Meo A, Tognoloni A, Seccaroni M, Beccati F. (2024). The Combined Use of Triamcinolone and Platelet-Rich Plasma in Equine Metacarpophalangeal Joint Osteoarthritis Treatments: An In Vivo and In Vitro Study. Animals (Basel), 14(24). https://doi.org/10.3390/ani14243645

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 24

Researcher Affiliations

Guidoni, Kübra
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Chiaradia, Elisabetta
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Pepe, Marco
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
  • Sport Horse Research Center, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Di Meo, Antonio
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Tognoloni, Alessia
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Seccaroni, Matteo
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Beccati, Francesca
  • Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
  • Sport Horse Research Center, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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