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Home / Equine Research Bank / Regen Med / The current ‘state of play’ of regenerative medi...
Regenerative medicine2014; 9(5); 673-685; doi: 10.2217/rme.14.42

The current ‘state of play’ of regenerative medicine in horses: what the horse can tell the human.

Abstract: The horse is an attractive model for many human age-related degenerative diseases of the musculoskeletal system because it is a large animal species that both ages and exercises, and develops naturally occurring injuries with many similarities to the human counterpart. It therefore represents an ideal species to use as a 'proving ground' for new therapies, most notably regenerative medicine. Regenerative techniques using cell-based therapies for the treatment of equine musculoskeletal disease have been in use for over a decade. This review article provides a summary overview of the sources, current challenges and problems surrounding the use of stem cell and non-cell-based therapy in regenerative medicine in horses and is based on presentations from a recent Havemeyer symposium on equine regenerative medicine where speakers are selected from leading authorities in both equine and human regenerative medicine fields from 10 different countries.
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Publication Date: 2014-11-06 PubMed ID: 25372081DOI: 10.2217/rme.14.42Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses how horses are a great model to study human age-related degenerative diseases of the musculoskeletal system and provides an overview of the challenges in using regenerative medicine in horses.

Why Horses are Ideal Models

  • The horse is chosen as an attractive model because it is a large animal species that ages and exercises, making it relatively similar to humans in these aspects.
  • Horses also develop naturally occurring injuries, many of which have strong parallels to human injuries, particularly those related to the musculoskeletal system.
  • This similarity positions the horse as an ideal species for testing new therapies, particularly in the field of regenerative medicine.

The Use of Regenerative Techniques in Horses

  • Regenerative techniques, involving the use of cell-based therapies for treating musculoskeletal disease in horses, have been deployed for over a decade.
  • This extensive use has provided a rich body of knowledge and experiences for researchers, further underscored by the size and physical attributes of the horse.
  • However, challenges and problems persist, which can offer insights for the development and refinement of human therapies.

Sources, Challenges and Problems in Equine Regenerative Medicine

  • The article presents a broad overview of the issues and challenges related to the use of stem cell and non-cell-based therapy in regenerative medicine for horses.
  • This synopsis is based on presentations from a Havemeyer symposium featuring leading experts in both equine and human regenerative medicine from 10 different countries.
  • The bringing together of these diverse sources of knowledge and expertise provides a potent summary of the state of regenerative medicine in horses and its implications for human medicine.

Cite This Article

APA
Smith RK, Garvican ER, Fortier LA. (2014). The current ‘state of play’ of regenerative medicine in horses: what the horse can tell the human. Regen Med, 9(5), 673-685. https://doi.org/10.2217/rme.14.42

Publication

Regenerative medicine
ISSN: 1746-076X
NlmUniqueID: 101278116
Country: England
Language: English
Volume: 9
Issue: 5
Pages: 673-685

Researcher Affiliations

Smith, Roger Kw
  • Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.
Garvican, Elaine R
    Fortier, Lisa A

      MeSH Terms

      • Animals
      • Cell Culture Techniques
      • Cell Differentiation
      • Disease Models, Animal
      • Horse Diseases / therapy
      • Horses
      • Humans
      • Musculoskeletal Diseases / therapy
      • Musculoskeletal Diseases / veterinary
      • Regenerative Medicine / methods
      • Regenerative Medicine / trends
      • Stem Cell Transplantation / veterinary
      • Stem Cells / cytology

      Citations

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