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Home / Equine Research Bank / J Mol Biol / The DNA sequence of equine herpesvirus 2.
Journal of molecular biology1995; 249(3); 520-528; doi: 10.1006/jmbi.1995.0314

The DNA sequence of equine herpesvirus 2.

Abstract: The complete DNA sequence of equine herpesvirus 2 (EHV-2) strain 86/67 was determined. The genome is 184,427 bp in size and has a base composition of 57.5% G + C. Unusually for a herpesvirus, about a third of the sequence distributed in several large blocks appears not to encode proteins. The 79 open reading frames that were identified as probably polypeptide-coding are predicted to encode 77 distinct proteins. Amino acid sequence comparisons confirmed that EHV-2 is a gamma-herpesvirus that is genetically collinear with herpesvirus saimiri (HVS; a gamma 2-herpesvirus) and Epstein-Barr virus (EBV; a gamma 1-herpesvirus), with a closer relationship to the former. Moreover, EHV-2 specifies eight proteins that have counterparts in HVS but not in EBV and only a single protein that has a homologue in EBV but not in HVS (EBV BCRF1, which encodes an interleukin 10-like protein). EHV-2 also encodes three potential G protein-coupled receptors, one with a counterpart in HVS that is specific for alpha chemokines, another with a counterpart in human cytomegalovirus (a beta-herpesvirus), which is specific for beta chemokines, and a third that is assigned more tentatively and lacks detectable counterparts in other herpesviruses.
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Publication Date: 1995-06-09 PubMed ID: 7783207DOI: 10.1006/jmbi.1995.0314Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study reports the complete DNA sequence of equine herpesvirus 2 (EHV-2), identifying 79 protein-coding sequences and classifying EHV-2 as a genetically collinear gamma-herpesvirus. Unusually for a herpesvirus, about a third of the EHV-2 sequence does not seem to code for proteins.

Overall DNA Sequence and Composition

  • The research paper explores the complete DNA sequence of equine herpesvirus 2 (EHV-2), a strain called 86/67. This is important as it advances our understanding of the genetic makeup of this herpesvirus that impacts horses.
  • According to their findings, the EHV-2 genome is 184,427 base pairs (bp) in size. The base composition consists of 57.5% Guanine and Cytosine (G + C), which are two of the four bases found in DNA molecules.
  • In comparison to other herpesviruses, a significant characteristic of EHV-2 is that about a third of its sequence, distributed in several large blocks, appears not to encode proteins, which is unique and nonstandard.

Protein Coding and Genetic Relationships

  • The researchers identified 79 open reading frames (ORFs) in the EHV-2 DNA sequence that are probably polypeptide-coding, which means they may be responsible for producing proteins essential for viral activities. These ORFs are predicted to encode 77 distinct proteins.
  • Upon comparing the amino acid sequences, it was confirmed that EHV-2 falls into the category of gamma-herpesviruses. Not only this, it is genetically collinear with herpesvirus saimiri (HVS; a gamma 2-herpesvirus) and Epstein-Barr virus (EBV; a gamma 1-herpesvirus), meaning they share similar gene layouts. EHV-2 was found to have a closer relationship or similarities with HVS.
  • The EHV-2 genome encodes eight proteins that have counterparts in HVS but not in EBV. In contrast, there is only one protein in EHV-2 that has a similar version or homologue in EBV but not in HVS (the protein identified is EBV BCRF1, which encodes an interleukin 10-like protein).

Specialized Protein Encodings

  • EHV-2 also codes for three potential G protein-coupled receptors, which are integral membrane proteins that can trigger cellular responses when they bind with specific molecules outside the cell. These are particularly important for various critical cellular processes and pathways.
  • One of the three G protein-coupled receptors in EHV-2 has a counterpart within HVS that is specific for alpha chemokines, which are small signaling proteins secreted by cells.
  • Another G protein-coupled receptor in EHV-2 has a counterpart within human cytomegalovirus (a beta-herpesvirus), which is specifically designed to bind with beta chemokines. The third receptor is tentatively assigned, and currently lacks detectable counterparts in other herpesviruses.

Cite This Article

APA
Telford EA, Watson MS, Aird HC, Perry J, Davison AJ. (1995). The DNA sequence of equine herpesvirus 2. J Mol Biol, 249(3), 520-528. https://doi.org/10.1006/jmbi.1995.0314

Publication

Journal of molecular biology
ISSN: 0022-2836
NlmUniqueID: 2985088R
Country: Netherlands
Language: English
Volume: 249
Issue: 3
Pages: 520-528

Researcher Affiliations

Telford, E A
  • Institute of Virology, University of Glasgow, UK.
Watson, M S
    Aird, H C
      Perry, J
        Davison, A J

          MeSH Terms

          • Amino Acid Sequence
          • Animals
          • Base Composition
          • Base Sequence
          • DNA, Viral / genetics
          • GTP-Binding Proteins / metabolism
          • Gammaherpesvirinae / genetics
          • Genome, Viral
          • Herpesvirus 2, Saimiriine / genetics
          • Herpesvirus 4, Human / genetics
          • Horses
          • Humans
          • Molecular Sequence Data
          • Open Reading Frames
          • Receptors, Cell Surface / genetics
          • Receptors, Cell Surface / metabolism
          • Sequence Homology, Amino Acid
          • Species Specificity
          • Viral Proteins / genetics

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