The effect of acetylsalicylic acid and captopril on uterine and ovarian blood flow during the estrous cycle in mares.
Abstract: In previous studies, transrectal color Doppler sonography was used to demonstrate an increase in genital blood flow resistance in subfertile mares. The objectives of the present study were to determine the effects of an anticoagulant (acetylsalicylic acid) and a vasodilator (captopril) on uterine and ovarian perfusion and plasma progesterone concentrations in cycling mares. From Day 1 to 11 of an estrous cycle (Day 0=day of ovulation following prostaglandin-induced luteolysis), five Trotter mares were given 2500 mg lactose, 2500 mg ASA, or 50 mg captopril twice daily in their feed (one compound per cycle, in random order). Transrectal color Doppler sonography was used to examine both uterine arteries and the ovarian artery ipsilateral to the corpus luteum once daily, immediately prior to administration of the drug. Blood flow resistance was determined semiquantitatively using the pulsatility index (PI) and plasma progesterone concentrations were determined with an enzyme immunoassay. Compared to the placebo, both ASA and captopril decreased mean PI values of both uterine arteries of all mares. On average, ASA decreased the PI of the uterine arteries by 25%; this was more (P<0.05) than the average decrease (13%) caused by captopril. Both drugs decreased (P<0.05) blood flow resistance in the ovarian arteries, although there was no difference (P<0.05) in their efficacy. In addition, both ASA and captopril increased (P<0.0001) plasma progesterone concentrations (18 and 17%, respectively). In conclusion, either ASA or captopril improved uterine and ovarian perfusion; however the effects on fertility were not determined.
Publication Date: 2003-12-10 PubMed ID: 14662130DOI: 10.1016/s0093-691x(03)00214-0Google Scholar: Lookup
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- Journal Article
Summary
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The research article investigates how an anticoagulant (acetylsalicylic acid) and a vasodilator (captopril) influence uterine and ovarian blood flow, as well as plasma progesterone concentrations, during the estrous cycle in mares.
Overview of the Study
- The objective of the study was to better understand the effects of acetylsalicylic acid (ASA), an anticoagulant, and captopril, a vasodilator, on uterine and ovarian blood flow. The research team also investigated how these substances affect plasma progesterone concentrations in cycling mares during an estrous cycle.
- The study involved five Trotter mares that were given 2500 mg lactose, 2500 mg ASA, or 50 mg captopril twice daily in their feed from Day 1 to 11 of an estrous cycle.
Techniques and Measurements
- Transrectal colour Doppler sonography was utilized to take daily examinations of both uterine arteries and the ovarian artery on the same side as the corpus luteum (part of the ovary), right before the administration of the drug.
- Resistance to the blood flow was semi-quantitatively identified using the pulsatility index (PI), and the plasma progesterone concentrations were analysed with an enzyme immunoassay.
Results of the Study
- Compared to the placebo, both ASA and captopril were found to reduce the average PI values in the Ut and ovarian arteries in all the subject mares. Specifically, ASA decreased PI in uterine arteries by an average of 25%. This is larger than the average decrease of 13% caused by captopril.
- Both ASA and captopril resulted in lower blood flow resistance in the ovarian arteries. However, the study found no difference in the efficacy of the two drugs in this regard.
- Additionally, both the ASA and captopril treatments led to an increase in plasma progesterone concentrations. The increases were 18% and 17%, respectively.
Conclusion
- The study concluded that either ASA or captopril can improve uterine and ovarian perfusion. However, the effect of these drugs on fertility was not evaluated in the framework of this research.
Cite This Article
APA
Bollwein H, Weber F, Steffen S, Stolla R.
(2003).
The effect of acetylsalicylic acid and captopril on uterine and ovarian blood flow during the estrous cycle in mares.
Theriogenology, 61(2-3), 301-309.
https://doi.org/10.1016/s0093-691x(03)00214-0 Publication
Researcher Affiliations
- Department of Animal Reproduction, Veterinary College, University of Munich, Königinstr 12, 80539 Munich, Germany. Heinrich.Bollwein@gyn.vetmed.uni-muenchen.de
MeSH Terms
- Animals
- Anticoagulants / pharmacology
- Aspirin / pharmacology
- Captopril / pharmacology
- Estrous Cycle
- Female
- Horses / physiology
- Ovary / blood supply
- Ovary / drug effects
- Placebos
- Progesterone / blood
- Pulsatile Flow / drug effects
- Uterus / blood supply
- Uterus / drug effects
- Vasodilator Agents / pharmacology
Citations
This article has been cited 1 times.- Wang L, Huang X, Li X, Lv F, He X, Pan Y, Wang L, Zhang X. Efficacy evaluation of low-dose aspirin in IVF/ICSI patients evidence from 13 RCTs: A systematic review and meta-analysis.. Medicine (Baltimore) 2017 Sep;96(37):e7720.
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