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The effect of general anesthesia and abdominal surgery upon plasma thromboxane B concentrations in horses.
Abstract: To compare the effect of anesthesia alone with anesthesia and abdominal surgery on plasma thromboxane B(2) concentrations in horses. Methods: Non-randomized experimental study. Methods: Six male mixed-bred horses (5-12 years, 350 +/- 18 kg). Methods: All horses were anesthetized for 2.5 hours using halothane, and a month later abdominal surgery was performed using the same anesthetic technique with a similar duration. The schedule of anesthesia included pre-medication with diazepam (0.1 mg kg(-1) IM), followed by xylazine (2.2 mg kg(-1) IV), and 10 minutes later anesthesia was induced with ketamine hydrochloride (2.2 mg kg(-1) IV). After orotracheal intubation, anesthesia was maintained with halothane. Blood samples for the determination of thromboxane B(2) (TXB(2)) were obtained before, at induction, at 60 minutes after halothane was first inspired, and at recovery from anesthesia as well as at the corresponding stages of the experimental abdominal surgery (before induction, prior to laparotomy, enterectomy, enteroanastomosis, abdominal wall closure). Results: Baseline value for the anesthesia group was 76 +/- 12 pg mL(-1) and increased (p < 0.001) after 1 hour of anesthesia to 265 +/- 40 pg mL(-1). With surgery, the corresponding value was 285 +/- 21 pg mL(-1) (hour 1, p < 0.001) and 210 +/- 28 pg mL(-1) (hour 2, p < 0.001), respectively. These were not different from anesthesia alone. Conclusions: The increased concentrations of thromboxane B(2) between 1 and 2.5 hours of halothane anesthesia and during the corresponding stages of the surgical intervention suggested that the anesthetic technique caused a significant increase in thromboxane B(2) and that surgery did not appear to contribute to this response.
Publication Date: 2004-04-01 PubMed ID: 15053753DOI: 10.1111/j.1467-2987.2004.00129.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Comparative Study
- Journal Article
Summary
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This study evaluated the impact of general anesthesia and abdominal surgery on the levels of a certain type of plasma, thromboxane B2, in horses. The research determines that anesthesia significantly ups the concentration of thromboxane B2 and found no additional increase due to the surgery.
Methods
- The research was a non-randomized experimental study with a sample of six male mixed-bred horses between the ages of 5 and 12 years, with weights ranging within 350 +/- 18 kg.
- All horses were subjected to general anesthesia twice in the experiment–once alone and once in combination with abdominal surgery. These two events were separated by a month. The anesthesia lasted for 2.5 hours each time and used a halothane technique.
- Prior to anesthesia, the horses were premedicated using diazepam, then given xylazine ten minutes later. Anesthesia was then induced using ketamine hydrochloride and was maintained after orotracheal intubation using halothane.
- Blood samples were taken from the horses at multiple stages before, during, and after the anesthesia and surgery to measure the thromboxane B2 concentration.
Results
- It was found that the baseline thromboxane B2 concentration increased significantly after one hour of anesthesia. This increase maintained a similar trajectory when the anesthesia was administered for surgery.
- Statistically, it was found the increase in plasma thromboxane B2 during the second hour of anesthesia and during surgery was not significantly different from the increase during anesthesia alone.
Conclusion
- Under the context of the existing anesthesia technique, this study suggests a significant rise in thromboxane B2 during general anesthesia that remains elevated through 2.5 hours of the procedure.
- While the surgery would be assumed to further stimulate the release of the plasma, the researchers did not find evidence to claim that it contributed to the increase in thromboxane B2. Therefore, the increase in the concentration seems tied exclusively to the anesthesia.
Cite This Article
APA
Dinev D, Andonova M.
(2004).
The effect of general anesthesia and abdominal surgery upon plasma thromboxane B concentrations in horses.
Vet Anaesth Analg, 31(2), 146-149.
https://doi.org/10.1111/j.1467-2987.2004.00129.x Publication
Researcher Affiliations
- Department of Veterinary Surgery, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria. d.dinev@uni-sz.bg
MeSH Terms
- Abdomen / surgery
- Anesthesia, General / veterinary
- Anesthetics, Inhalation / administration & dosage
- Anesthetics, Inhalation / pharmacology
- Animals
- Diazepam / administration & dosage
- Diazepam / pharmacology
- Halothane / administration & dosage
- Halothane / pharmacology
- Horses / physiology
- Horses / surgery
- Hypnotics and Sedatives / administration & dosage
- Hypnotics and Sedatives / pharmacology
- Infusions, Intravenous / veterinary
- Injections, Intramuscular / veterinary
- Ketamine / administration & dosage
- Ketamine / pharmacology
- Male
- Preanesthetic Medication / veterinary
- Thromboxane B2 / blood
- Xylazine / administration & dosage
- Xylazine / pharmacology
Citations
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