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Home / Equine Research Bank / Equine Vet J / The effect of insulin infusion on heart rate and systemic bl...
Equine veterinary journal2019; 51(6); 733-737; doi: 10.1111/evj.13110

The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome.

Abstract: There is little evidence that horses with equine metabolic syndrome (EMS) have higher resting blood pressures than horses with normal insulin sensitivity. However, there are indications that EMS horses have an altered dynamic response to the cardiovascular effects of insulin. Objective: To examine heart rate and the systemic blood pressure response in EMS and control horses during insulin infusion. Methods: Cross-sectional study. Methods: Horses were examined with an oral sugar test (OST) and a euglycaemic hyperinsulinaemic clamp (EHC). Based on the results from the OST, the horses were classified as either EMS or control. Blood pressure was measured before the start of the EHC and at 60, 120 and 180 min of the EHC. Results: There were 16 EMS and 12 control horses. Mean resting heart rate was higher for EMS horses compared with control (35.6 ± 5.1 vs. 30.3 ± 3.5 beats/min). Systolic, diastolic and mean arterial blood pressure did not differ between groups at the start of the EHC. Blood pressure decreased gradually during the EHC in the control group, whereas the EMS group showed no decline in systolic, diastolic or mean arterial pressure. Conclusions: Limited number of horses. Conclusions: Horses with EMS have cardiovascular changes that affect resting heart rate and systemic blood pressure during insulin infusion.
© 2019 EVJ Ltd.
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Publication Date: 2019-04-05 PubMed ID: 30887546DOI: 10.1111/evj.13110Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study sought to understand how insulin infusion impacts the heart rate and systemic blood pressure of horses diagnosed with equine metabolic syndrome (EMS), finding that such horses exhibit greater resting heart rates, and unlike healthy horses, their blood pressure doesn’t decrease during insulin infusion.

Objective and Methods

  • The aim of this research was to study the difference in heart rate and blood pressure response during insulin infusion between horses with equine metabolic syndrome (EMS) and those without (control group).
  • To determine the groupings, an oral sugar test (OST) and a euglycaemic hyperinsulinaemic clamp (EHC), which are standard diagnostic tests for EMS, were performed on all horses.
  • If a horse registered a certain level on the OST, it was classified as having EMS. If it didn’t, it was placed in the control group.
  • The researchers monitored the blood pressure of these horses before and at specific intervals throughout the duration of the EHC.

Results

  • A total of 28 horses (16 EMS and 12 control) were involved in the study.
  • The results uncovered that horses with EMS had higher average resting heart rates than the control group. Specifically, the average resting heart rate for EMS horses was measured at 35.6 beats per minute, in contrast to the control group’s 30.3 beats per minute.
  • Both groups started with the same levels of systolic, diastolic, and mean arterial blood pressure.
  • Throughout the EHC, the control group’s blood pressure decreased progressively. In contrast, the EMS group maintained the same levels of systolic, diastolic, or mean arterial pressure, showing no decline.

Conclusions

  • The study suffers from a limited number of horses, which could impact the generalizability of its findings.
  • Despite this limitation, the research established that horses with EMS have notable cardiovascular changes in terms of resting heart rate and adaption of systemic blood pressure in response to insulin infusion.
  • These insights are significant given the potential for the careful management and treatment of EMS in horses.

Cite This Article

APA
Nostell K, Lindåse S, Edberg H, Bröjer J. (2019). The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome. Equine Vet J, 51(6), 733-737. https://doi.org/10.1111/evj.13110

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 51
Issue: 6
Pages: 733-737

Researcher Affiliations

Nostell, K
  • Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
Lindåse, S
  • Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
Edberg, H
  • Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
Bröjer, J
  • Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.

MeSH Terms

  • Animals
  • Blood Pressure
  • Glucose Clamp Technique
  • Horse Diseases / blood
  • Horse Diseases / physiopathology
  • Horses
  • Insulin
  • Insulin Resistance / physiology
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / veterinary

Grant Funding

  • Swedish - Norwegian Foundation for Equine Research

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Citations

This article has been cited 3 times.
  1. D' Fonseca NMM, Beukers M, Wijnberg ID, Navas de Solis C, de Ruijter-Villani M, van Doorn DA, Stout TAE, Roelfsema E. Effect of a long-term high-energy diet on cardiovascular parameters in Shetland pony mares.. J Vet Intern Med 2021 Sep;35(5):2427-2436.
    doi: 10.1111/jvim.16229pubmed: 34350640google scholar: lookup
  2. Lindåse S, Nostell K, Bergsten P, Forslund A, Bröjer J. Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses.. BMC Vet Res 2021 Feb 15;17(1):78.
    doi: 10.1186/s12917-021-02781-5pubmed: 33588833google scholar: lookup
  3. da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ, Hall JE. Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.. Can J Cardiol 2020 May;36(5):671-682.
    doi: 10.1016/j.cjca.2020.02.066pubmed: 32389340google scholar: lookup
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