The effect of oxytocin and PGF2alpha on the uterine involution and pregnancy rates in postpartum Arabian mares.
Abstract: In this study, the effects of oxytocin and an analog of prostaglandin (cloprostenol) on the uterine involution and pregnancy rates were investigated. Mares received 3 ml of 0.9% NaCl in Group C (n=10), 30 IU/mare of oxytocin in Group O (n=10) and 250 microg/mare of cloprostenol in Group P (n=10) within 12h after parturition. The gravid uterine horn's cross-sectional diameter was measured by ultrasonography. The mean uterine diameters did not differ significantly between the treatment (O and P) and the control (C) groups (p>0.05). The difference between the postpartum ovulation periods (Group C: 12.6+/-0.72 days, Group O: 15+/-1.33 days, Group P: 14.6+/-1.11 days), the pregnancy rates at foal heat (Group C: 60%, Group O: 60%, Group P: 80%) and the embryonic death rates at foal heat (Group C: 33.3%, Group O: 16%, Group P: 25%) were not found to be statistically significant between the treatment and the control groups. The mean progesterone concentrations were similar in all groups and decreased continuously from parturition to until foal heat (Group C: from 2.43+/-0.24 to 0.66 ng/ml, Group O: from 3.07+/-0.6 to 0.27+/-0.27 ng/ml and Group P: from 2.8+/-0.44 to 0 ng/ml) (p>0.05). In conclusion, it was decided that the oxytocin and PGF2alpha treatments performed on the mares with the purpose of stimulating involution had no effect on the duration of parturition-first ovulation, the shrinkage of the uterus diameter, the pregnancy and embryonic death rates.
Publication Date: 2007-02-22 PubMed ID: 17391875DOI: 10.1016/j.anireprosci.2007.02.004Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research investigates the impact of oxytocin and cloprostenol treatments on uterine contraction and pregnancy success rates in Arabian mares after giving birth. The study concluded the treatments do not significantly impact postpartum ovulation periods, uterine reduction, and rates of pregnancy or embryonic death.
Research Methodology
In this study:
- Arabian mares were split into three groups: the control group (Group C) which received 3 ml of saline solution (0.9% NaCl), and two treatment groups which received either oxytocin (Group O) or cloprostenol (Group P). Each treatment group was administered with specific doses of the treatment within 12 hours of giving birth. Group O got 30 IU/mare of oxytocin while Group P received 250 microg/mare of cloprostenol.
- The sizes of the mares’ pregnant uterine horns were measured using ultrasonography. This was carried out to observe the effect of treatments on uterine involution (shrinking).
- The researchers monitored the postpartum ovulation periods, the rates of pregnancy, and embryonic death rates at foal heat in the three groups. Foal heat refers to the first heat experienced by the mare after giving birth.
Findings
The results were as follows:
- The uterine diameters did not significantly differ between the control group and the treatment groups.
- The differences in the postpartum ovulation periods for the three groups were not statistically significant. Also, the pregnancy rates and embryonic death rates at foal heat were not significantly different across the groups.
- The average progesterone concentrations were at similar levels in all groups and showed a steady decrease from parturition until foal heat.
Conclusion
The study concluded that the treatments used with the intention of stimulating uterine involution had no significant effects on the time period between birth and first ovulation, the uterine involution process, and the rates of pregnancy or embryonic death. Therefore, these treatments may not be necessary for management of postpartum Arabian mares.
Cite This Article
APA
Gündüz MC, Kaşikçi G, Kaya HH.
(2007).
The effect of oxytocin and PGF2alpha on the uterine involution and pregnancy rates in postpartum Arabian mares.
Anim Reprod Sci, 104(2-4), 257-263.
https://doi.org/10.1016/j.anireprosci.2007.02.004 Publication
Researcher Affiliations
- Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Istanbul, Avcilar 34320, Istanbul, Turkey. mcg@istanbul.edu.tr
MeSH Terms
- Animals
- Animals, Newborn
- Female
- Fetal Death
- Horses / physiology
- Male
- Ovulation / drug effects
- Ovulation / physiology
- Oxytocin / pharmacology
- Postpartum Period
- Pregnancy
- Progesterone / blood
- Random Allocation
- Ultrasonography
- Uterus / diagnostic imaging
- Uterus / drug effects
- Uterus / physiology
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