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Veterinary research communications1994; 18(5); 373-381; doi: 10.1007/BF01839288

The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies.

Abstract: The effects of various concentrations of furosemide and pentoxifylline on equine RBC in vitro were evaluated to facilitate better understanding of the potential effects of these drugs on blood flow properties. Furosemide induced increased mean cell volume (MCV), increased RBC potassium concentration, increased whole blood viscosity, and decreased the RBC filtrability. These data indicate that furosemide may block the RBC membrane transport pathways resulting in potassium and water retention. The increase in size and the resultant decrease in the surface-area-to-volume ratio may have caused the impaired RBC filtrability and increased blood viscosity. Pentoxifylline improved RBC filtrability without changing the RBC size or the potassium or chloride concentrations, suggesting that pentoxifylline may increase the deformability of the RBC membrane. The study indicated that pentoxifylline has potential therapeutic applications for improving microvascular blood flow but that furosemide may have adverse effects on blood flow.
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Publication Date: 1994-01-01 PubMed ID: 7863609DOI: 10.1007/BF01839288Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the impact of the drugs furosemide and pentoxifylline on the properties of horse red blood cells in a laboratory setting. It was discovered that furosemide could cause changes negatively impacting blood flow, whereas pentoxifylline could potentially improve it.

Study Objectives and Approach

  • The research aimed to study the potential effects of different concentrations of furosemide and pentoxifylline on the properties of red blood cells (RBCs) in horses.
  • This investigation was approached from in vitro or laboratory conditions, which means that it was conducted outside of a living organism.
  • The effects of these drugs on RBC characteristics such as volume, potassium concentration, blood viscosity, and RBC filtrability were the primary concerns.

Key Findings

  • Furosemide was found to increase the mean cell volume, RBC potassium concentration, and the viscosity of whole blood. It also reduced the RBC filtrability.
  • This suggests that furosemide may interfere with (or “block”) the pathways across the red blood cell membrane, causing potassium and water to be retained in the cell.
  • The expanded size of cells and reduced surface-area-to-volume ratio may be responsible for the decreased RBC filtrability and increased blood viscosity.
  • On the other hand, pentoxifylline improved the RBC’s ability to be filtered without causing changes in its size or concentrations of potassium and chloride molecules.
  • This suggests that pentoxifylline may enhance the deformability (flexibility) of the red blood cell membrane.

Research Implications

  • This study highlights potential therapeutic applications of pentoxifylline for improving microvascular blood flow, owing to its effects on red blood cell characteristics.
  • In contrast, the use of furosemide might have adverse effects on blood flow, presumably due to how it impacts red blood cell properties and behaviours.
  • This study provides valuable insights to guide medical decisions for equine health, particularly regarding drug implications for their blood flow and cell characteristics.

Cite This Article

APA
Weiss DJ, Evanson OA, Geor RJ. (1994). The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies. Vet Res Commun, 18(5), 373-381. https://doi.org/10.1007/BF01839288

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 18
Issue: 5
Pages: 373-381

Researcher Affiliations

Weiss, D J
  • Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Evanson, O A
    Geor, R J

      MeSH Terms

      • Animals
      • Blood Viscosity / drug effects
      • Erythrocyte Indices / drug effects
      • Erythrocyte Indices / veterinary
      • Erythrocytes / chemistry
      • Erythrocytes / drug effects
      • Erythrocytes / physiology
      • Furosemide / pharmacology
      • Horses / blood
      • Pentoxifylline / pharmacology
      • Potassium / analysis
      • Regional Blood Flow

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      Citations

      This article has been cited 0 times.
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