FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Advances in experimental medicine and biology2013; 784; 63-87; doi: 10.1007/978-1-4614-6199-9_4

The effects of kisspeptin on gonadotropin release in non-human mammals.

Abstract: The Kiss1 gene encodes a 145-amino acid pre-peptide, kisspeptin, which is cleaved into smaller peptides of 54, 14, 13, and 10 amino acids. This chapter reviews in detail the effects of kisspeptin on gonadotropin secretion in non-human mammals. Studies of kisspeptin's effects have included both acute and chronic administration regimens via a number of administration routes. Acute kisspeptin stimulates gonadotropin secretion in a wide range of species of non-human mammals, including rats, mice, hamsters, sheep, pigs, goats, cows, horses, and monkeys. In general, the stimulatory effect of kisspeptin treatment is more pronounced for LH than FSH secretion. Kisspeptin is thought to exert its stimulatory effects on LH and FSH release via stimulation of GnRH release from the hypothalamus, since pre--administration of a GnRH antagonist prevents kisspeptin's stimulation of gonadotropin secretion. Although the kisspeptin receptor is also expressed on anterior pituitary cells of some species, and incubation of anterior pituitary cells with high concentrations of kisspeptin can stimulate in vitro LH release, the contribution of direct effects of kisspeptin on the pituitary is thought to be negligible in vivo. Continuous kisspeptin administration results in reduced sensitivity to the effects of kisspeptin, in some species. This desensitization is thought to occur at the level of the kisspeptin receptor, since the response of the pituitary gland to exogenous GnRH is maintained. Overall, the findings discussed in this chapter are invaluable to the understanding of the reproductive role of kisspeptin and the potential therapeutic uses of kisspeptin for the treatment of fertility disorders.
Get Full Text
Publication Date: 2013-04-04 PubMed ID: 23550002DOI: 10.1007/978-1-4614-6199-9_4Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews the impact of a hormone called kisspeptin on the secretion of other hormones that control reproduction in non-human mammals. It particularly focuses on the variations seen in these effects across different species and how kisspeptin interacts with different parts of the endocrine system.

Understanding Kisspeptin

  • The Kiss1 gene produces a pre-peptide, named ‘kisspeptin,’ made up of 145 amino acids. This gets broken down into smaller peptides.
  • Kisspeptin is a hormone that influences the release of other hormones called gonadotropins, which play a vital role in reproductive processes.

Methodology

  • The effects of this hormone were studied both when given acutely – in a single dose – and chronically, over a longer period of time, and through various administration methods.
  • The impact of kisspeptin was studied in a wide variety of non-human mammals including rodents, ungulates, and primates.

Key Findings

  • Generally, kisspeptin stimulates the release of gonadotropins, impacting the secretion of LH (luteinizing hormone) more significantly than FSH (follicle-stimulating hormone).
  • Kisspeptin likely stimulates the release of LH and FSH by triggering the release of another hormone, GnRH (gonadotropin-releasing hormone), from the brain’s hypothalamus. This action is supported by the observation that preventing GnRH release also prevents the stimulation of gonadotropin secretion by kisspeptin.
  • The kisspeptin receptor, which kisspeptin binds to stimulate these processes, is found on the cells of the pituitary gland in some species. However, despite these receptors and the fact that high concentrations of kisspeptin can stimulate LH release when directly applied to these pituitary cells, it’s believed this direct interaction plays a negligible role in a live animal’s body.
  • One important observation was that the effect of kisspeptin can decrease with continuous administration in some animals due to a process called desensitization. This is thought to happen at the level of the kisspeptin receptor, yet the pituitary gland’s response to external GnRH remains the same.

Significance of the Study and Future Directions

  • Overall, these findings provide valuable insights into kisspeptin’s role in reproduction and its potential therapeutic uses in treating fertility disorders.

Cite This Article

APA
Abbara A, Ratnasabapathy R, Jayasena CN, Dhillo WS. (2013). The effects of kisspeptin on gonadotropin release in non-human mammals. Adv Exp Med Biol, 784, 63-87. https://doi.org/10.1007/978-1-4614-6199-9_4

Publication

Advances in experimental medicine and biology
ISSN: 0065-2598
NlmUniqueID: 0121103
Country: United States
Language: English
Volume: 784
Pages: 63-87

Researcher Affiliations

Abbara, Ali
  • Department of Investigative Medicine, Imperial College, London, UK. ali.abbara@imperial.ac.uk
Ratnasabapathy, Risheka
    Jayasena, Channa N
      Dhillo, Waljit S

        MeSH Terms

        • Animals
        • Cattle
        • Cricetinae
        • Follicle Stimulating Hormone / metabolism
        • Goats
        • Gonadotropin-Releasing Hormone
        • Gonadotropins / metabolism
        • Haplorhini
        • Horses
        • Infertility / drug therapy
        • Infertility / metabolism
        • Infertility / veterinary
        • Kisspeptins / metabolism
        • Kisspeptins / pharmacology
        • Luteinizing Hormone / metabolism
        • Mice
        • Pituitary Gland, Anterior / metabolism
        • Rats
        • Receptors, G-Protein-Coupled / metabolism
        • Receptors, Kisspeptin-1
        • Sheep

        Grant Funding

        • CDF-2009-02-05 / Department of Health
        • G1000455 / Medical Research Council
        • Biotechnology and Biological Sciences Research Council

        Citations

        This article has been cited 14 times.
        1. Dinh H, Kovács ZZA, Márványkövi F, Kis M, Kupecz K, Szűcs G, Freiwan M, Lauber GY, Acar E, Siska A, Ibos KE, Bodnár É, Kriston A, Kovács F, Horváth P, Földesi I, Cserni G, Podesser BK, Pokreisz P, Kiss A, Dux L, Csabafi K, Sárközy M. The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Sci Rep 2023 Aug 28;13(1):14046.
          doi: 10.1038/s41598-023-41037-0pubmed: 37640761google scholar: lookup
        2. Merkley CM, Shuping SL, Sommer JR, Nestor CC. Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep. Metabolites 2021 Feb 26;11(3).
          doi: 10.3390/metabo11030138pubmed: 33652696google scholar: lookup
        3. Abbara A, Eng PC, Phylactou M, Clarke SA, Richardson R, Sykes CM, Phumsatitpong C, Mills E, Modi M, Izzi-Engbeaya C, Papadopoulou D, Purugganan K, Jayasena CN, Webber L, Salim R, Owen B, Bech P, Comninos AN, McArdle CA, Voliotis M, Tsaneva-Atanasova K, Moenter S, Hanyaloglu A, Dhillo WS. Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. J Clin Invest 2020 Dec 1;130(12):6739-6753.
          doi: 10.1172/JCI139681pubmed: 33196464google scholar: lookup
        4. D'Occhio MJ, Campanile G, Baruselli PS. Peripheral action of kisspeptin at reproductive tissues-role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review. Biol Reprod 2020 Dec 1;103(6):1157-1170.
          doi: 10.1093/biolre/ioaa135pubmed: 32776148google scholar: lookup
        5. Amodei R, Gribbin K, He W, Lindgren I, Corder KR, Jonker SS, Estill CT, Coolen LM, Lehman MN, Whitler W, Stormshak F, Roselli CE. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep. Endocrinology 2020 Apr 1;161(4).
          doi: 10.1210/endocr/bqaa013pubmed: 32005991google scholar: lookup
        6. Kong ZL, Sudirman S, Hsu YC, Su CY, Kuo HP. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. Int J Mol Sci 2019 Sep 11;20(18).
          doi: 10.3390/ijms20184485pubmed: 31514311google scholar: lookup
        7. Sudirman S, Hsu YH, Johnson A, Tsou D, Kong ZL. Amelioration effects of nanoencapsulated triterpenoids from petri dish-cultured Antrodia cinnamomea on reproductive function of diabetic male rats. Int J Nanomedicine 2018;13:5059-5073.
          doi: 10.2147/IJN.S172906pubmed: 30233173google scholar: lookup
        8. Stamou MI, Georgopoulos NA. Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism. Metabolism 2018 Sep;86:124-134.
          doi: 10.1016/j.metabol.2017.10.012pubmed: 29108899google scholar: lookup
        9. Gao X, Zhang K, Song M, Li X, Luo L, Tian Y, Zhang Y, Li Y, Zhang X, Ling Y, Fang F, Liu Y. Role of Nesfatin-1 in the Reproductive Axis of Male Rat. Sci Rep 2016 Sep 7;6:32877.
          doi: 10.1038/srep32877pubmed: 27599613google scholar: lookup
        10. Sridhar A, Khan D, Muthukumar R, Sampathkumar S, Irwin N, Flatt PR, Moffett RC. Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice. Biomolecules 2025 Nov 13;15(11).
          doi: 10.3390/biom15111591pubmed: 41301510google scholar: lookup
        11. Kotanidou S, Nikolettos N, Kritsotaki N, Tsikouras P, Tiptiri-Kourpeti A, Nikolettos K. Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment. J Clin Med 2025 May 8;14(10).
          doi: 10.3390/jcm14103284pubmed: 40429279google scholar: lookup
        12. Sliwowska JH, Woods NE, Alzahrani AR, Paspali E, Tate RJ, Ferro VA. Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction. J Diabetes 2024 Apr;16(4):e13541.
          doi: 10.1111/1753-0407.13541pubmed: 38599822google scholar: lookup
        13. Dinh H, Kovács ZZA, Kis M, Kupecz K, Sejben A, Szűcs G, Márványkövi F, Siska A, Freiwan M, Pósa SP, Galla Z, Ibos KE, Bodnár É, Lauber GY, Goncalves AIA, Acar E, Kriston A, Kovács F, Horváth P, Bozsó Z, Tóth G, Földesi I, Monostori P, Cserni G, Podesser BK, Lehoczki A, Pokreisz P, Kiss A, Dux L, Csabafi K, Sárközy M. Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy. Geroscience 2024 Apr;46(2):2463-2488.
          doi: 10.1007/s11357-023-01017-8pubmed: 37987885google scholar: lookup
        14. Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S, Papadopoulou D, Roberts R, Izzi-Engbeaya C, Ratnasabapathy R, Nesbitt A, Vimalesvaran S, Salim R, Lavery SA, Bloom SR, Huson L, Trew GH, Dhillo WS. A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial. Hum Reprod 2017 Sep 1;32(9):1915-1924.
          doi: 10.1093/humrep/dex253pubmed: 28854728google scholar: lookup
        Subscribe to our newsletter
        Join 99,780 horse owners like you who receive our email updates on horse health and nutrition.