The Electrophoresis of the Blood Platelets of the Horse with Reference to Their Origin and to Thrombus Formation.
Abstract: 1. The cataphoretic velocity of blood platelets (horse) in plasma has been found to be between 40 and 51 micro per sec. per volt per cm. The mean velocity obtained from five horses is . 45 micro per sec. per volt per cm. 2. The cataphoretic velocity of polymorphonuclear leucocytes in similar specimens is practically identical with that of the platelets. This is noteworthy because of the fact that lymphocytes and red cells have different speeds. 3. With spontaneous agglutination of platelets, white cells and red cells, there is no change in the cataphoretic velocity incidental to aggregation. 4. The possible surface composition of platelets and white cells is briefly discussed. 5. The bearing of these findings on the origin of blood platelets and the mechanism of thrombus formation is demonstrated.
Publication Date: 1928-04-30 PubMed ID: 19869437PubMed Central: PMC2131403DOI: 10.1084/jem.47.5.677Google Scholar: Lookup
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- Journal Article
Summary
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The study examines the speed at which blood platelets in horses move in plasma, comparing this with other blood components, and considers implications for the origin of blood platelets and blood clot formation.
Methods
- The researchers conducted an in-depth examination of the cataphoretic velocity of blood platelets (horse) in plasma. Cataphoretic velocity refers to the rate at which charged particles migrate in a fluid upon being influenced by an electric field.
- Findings were gathered from five different horses, ensuring a varied sample and more accurate results.
- As a comparator, the study also examined the cataphoretic velocity of polymorphonuclear leucocytes (a type of white blood cell) in similar specimens.
Results
- The velocity of blood platelets was found to range between 40 and 51 micro per sec. per volt per cm, with an average velocity of .45 micro per sec. per volt per cm derived from all the five horses.
- Interestingly, polymorphonuclear leucocytes were found to have practically identical cataphoretic velocities to that of the platelets. This was surprising given the varying cataphoretic velocities observed in lymphocytes and red blood cells.
- It was observed that spontaneous agglutination (clumping together) of platelets, white cells, and red cells did not change the cataphoretic velocity of the blood components.
Discussion
- The surface composition of platelets and white cells, which largely influences their cataphoretic velocities, was examined.
- The researchers then explored how these findings could provide insights into the origin of blood platelets and the mechanism of thrombus (blood clot) formation.
Cite This Article
APA
Abramson HA.
(1928).
The Electrophoresis of the Blood Platelets of the Horse with Reference to Their Origin and to Thrombus Formation.
J Exp Med, 47(5), 677-683.
https://doi.org/10.1084/jem.47.5.677 Publication
Researcher Affiliations
- Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry, Berlin-Dahlem, Germany.
References
This article includes 3 references
- Bunting CH. BLOOD-PLATELET AND MEGALOKARYOCYTE REACTIONS IN THE RABBIT.. J Exp Med 1909 Jul 17;11(4):541-52.
- Brown WH. THE HISTOGENESIS OF BLOOD PLATELETS.. J Exp Med 1913 Sep 1;18(3):278-86.
- Abramson HA. THE MECHANISM OF THE INFLAMMATORY PROCESS : I. THE ELECTROPHORESIS OF THE BLOOD CELLS OF THE HORSE AND ITS RELATION TO LEUCOCYTE EMIGRATION.. J Exp Med 1927 Nov 30;46(6):987-1002.
Citations
This article has been cited 5 times.- Wang M, Zhang W, Qi Z. Platelet Deposition Onto Vascular Wall Regulated by Electrical Signal.. Front Physiol 2021;12:792899.
- Radke D, Jia W, Sharma D, Fena K, Wang G, Goldman J, Zhao F. Tissue Engineering at the Blood-Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development.. Adv Healthc Mater 2018 Aug;7(15):e1701461.
- Karagkiozaki V, Logothetidis S, Lousinian S, Giannoglou G. Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications.. Int J Nanomedicine 2008;3(4):461-9.
- Brossmer R, Pfleiderer T. [On the mechanism of thrombocyte aggregation. I. The importance of charging high molecular weight substances, particularly dextran derivatives, for aggregation in vitro].. Naturwissenschaften 1966 Sep;53(18):464-6.
- Mustard JF, Packham MA. Platelets, thrombosis and drugs.. Drugs 1975;9(1):19-76.
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