The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis.
Abstract: The genetic influence on chronic hypersensitivity bronchitis (CB) was investigated in families at two studs and among half-siblings of three affected and three non-affected sires at several farms. The family members at the two studs were born and raised under the same conditions, whereas the half-siblings were kept individually under very different conditions and were exposed to various environmental factors. The diagnosis was based on long-term observations and multiple clinical examinations at each of the two studs. In the half-sibling group, the diagnosis was based on the individual history and on a thorough clinical examination. The history of all horses suggested the disease was caused by allergies (symptoms provoked by hay). Statistical analysis of the data in the first study showed that a greater percentage of off-spring of two affected parents developed CB (9 of 13) than those with only one affected parent (23 of 48) and those with two healthy parents (5 of 29). The distributions of the affected offspring in these three categories (none, one or both parents affected) differed significantly (P less than 0.005) from what would have been expected without a genetic effect. The tendency to develop the disease was inherited equally from dams or sires. In the second stud fewer animals (n = 42) were included in the study, but the results were similar. Parents without a history of CB produced off-spring with a low incidence of disease (1 of 16) compared with a higher incidence among descendants of one or two affected parents (10 of 26; P = 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1991-11-01 PubMed ID: 1778165DOI: 10.1111/j.2042-3306.1991.tb03761.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigates the genetic influence on equine chronic hypersensitivity bronchitis (CB), analyzing the occurrence of CB in horses with affected and non-affected parents, born and reared under various conditions.
Study Design and Setting
- The study focused on the genetic impact on Chronic hypersensitivity bronchitis (CB) in horses across two studs and among half-siblings from three affected and non-affected sires on different farms.
- At the two studs, all horses were born and raised under identical conditions. In contrast, the half-siblings were individually kept under varying conditions, exposed to multiple environmental factors.
Research Methodology
- The diagnosis of CB was based on long-term observations and multiple clinical examinations at each of the two studs.
- In the half-sibling group, diagnosis relied on individual horses’ history and a detailed clinical examination.
- The history collected from all horses suggested that the disease was provoked by allergies, particularly symptoms triggered by hay.
Results
- Data analysis from the first study revealed that offspring from two affected parents had a higher incidence of CB (9 out of 13), compared to those with only one affected parent (23 out of 48) and those with two healthy parents (5 out of 29).
- Disease distributions in these three categories deviated significantly from those anticipated without a genetic effect. The tendency to develop the disease appeared to be equally inheritable from dams or sires.
Findings at the Second Stud
- In the second stud, fewer animals (n = 42) were involved in the study, but the findings were similar.
- A low incidence of disease (1 of 16) was observed in offspring produced by parents with no CB history, in contrast to a higher incidence among descendants of one or two affected parents (10 of 26).
Cite This Article
APA
Marti E, Gerber H, Essich G, Oulehla J, Lazary S.
(1991).
The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis.
Equine Vet J, 23(6), 457-460.
https://doi.org/10.1111/j.2042-3306.1991.tb03761.x Publication
Researcher Affiliations
- Klinik für Nutztiere und Pferde, University of Berne, Switzerland.
MeSH Terms
- Animals
- Bronchitis / genetics
- Bronchitis / veterinary
- Chronic Disease
- Female
- Horse Diseases / genetics
- Horses
- Hypersensitivity / genetics
- Hypersensitivity / veterinary
- Male
Citations
This article has been cited 19 times.- Simões J, Batista M, Tilley P. The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing. Animals (Basel) 2022 Mar 16;12(6).
- Borowska A, Wolska D, Niedzwiedz A, Borowicz H, Jaworski Z, Siemieniuch M, Szwaczkowski T. Some Genetic and Environmental Effects on Equine Asthma in Polish Konik Horses. Animals (Basel) 2021 Aug 3;11(8).
- Davis KU, Sheats MK. The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses. Inflammation 2021 Apr;44(2):450-465.
- Couetil L, Cardwell JM, Leguillette R, Mazan M, Richard E, Bienzle D, Bullone M, Gerber V, Ivester K, Lavoie JP, Martin J, Moran G, Niedźwiedź A, Pusterla N, Swiderski C. Equine Asthma: Current Understanding and Future Directions. Front Vet Sci 2020;7:450.
- Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
- Tessier L, Côté O, Bienzle D. Sequence variant analysis of RNA sequences in severe equine asthma. PeerJ 2018;6:e5759.
- Pacholewska A, Kraft MF, Gerber V, Jagannathan V. Differential Expression of Serum MicroRNAs Supports CD4⁺ T Cell Differentiation into Th2/Th17 Cells in Severe Equine Asthma. Genes (Basel) 2017 Dec 12;8(12).
- Klier J, Geis S, Steuer J, Geh K, Reese S, Fuchs S, Mueller RS, Winter G, Gehlen H. A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model. Immun Inflamm Dis 2018 Mar;6(1):81-96.
- Pacholewska A, Marti E, Leeb T, Jagannathan V, Gerber V. LPS-induced modules of co-expressed genes in equine peripheral blood mononuclear cells. BMC Genomics 2017 Jan 5;18(1):34.
- Saastamoinen M, Särkijärvi S, Hyyppä S. Reducing Respiratory Health Risks to Horses and Workers: A Comparison of Two Stall Bedding Materials. Animals (Basel) 2015 Oct 8;5(4):965-77.
- Pacholewska A, Jagannathan V, Drögemüller M, Klukowska-Rötzler J, Lanz S, Hamza E, Dermitzakis ET, Marti E, Leeb T, Gerber V. Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma. PLoS One 2015;10(8):e0136103.
- Bosshard S, Gerber V. Evaluation of coughing and nasal discharge as early indicators for an increased risk to develop equine recurrent airway obstruction (RAO). J Vet Intern Med 2014 Mar-Apr;28(2):618-23.
- da Silva AC, Brass KE, da Silva Loreto E, Vinocur ME, Pozzobon R, da Silva Azevedo M. Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses. Genet Mol Biol 2011 Jul;34(3):456-8.
- Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer. Equine Vet J 2010 Oct;42(7):658-70.
- Swinburne JE, Bogle H, Klukowska-Rötzler J, Drögemüller M, Leeb T, Temperton E, Dolf G, Gerber V. A whole-genome scan for recurrent airway obstruction in Warmblood sport horses indicates two positional candidate regions. Mamm Genome 2009 Aug;20(8):504-15.
- Theegarten D, Sachse K, Mentrup B, Fey K, Hotzel H, Anhenn O. Chlamydophila spp. infection in horses with recurrent airway obstruction: similarities to human chronic obstructive disease. Respir Res 2008 Jan 29;9(1):14.
- Mousavi M, Rabbani H, Hammarström L. Characterization of the bovine epsilon gene. Immunology 1997 Nov;92(3):369-73.
- Simões J, Tilley P. Decision Making in Severe Equine Asthma-Diagnosis and Monitoring. Animals (Basel) 2023 Dec 16;13(24).
- Robins TJ, Bedenice D, Mazan M. A Longitudinal Analysis of Equine Asthma Presentation and Response to Treatment Using Lung Function Testing and BAL Cytology Analysis in Combination with Owner Perception. Animals (Basel) 2023 Nov 1;13(21).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
