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Virus genes1993; 7(1); 111-116; doi: 10.1007/BF01702353

The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene.

Abstract: A gene was identified within the DNA sequences of the EcoRI DNA fragment N (4.3 kbp) of the genome of equine herpesvirus type 2 (EHV-2) coding for a protein (179 amino acid residues) homologous to the cytokine synthesis inhibitory factor (CSIF; interleukin 10) of the human and mouse, and to the Epstein-Barr virus (EBV) protein BCRF1. This finding is further significant evidence that the interleukin 10 (IL-10) and/or IL-10-like gene can indeed be present in the genomes of members of the herpesviral family.
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Publication Date: 1993-02-01 PubMed ID: 8385838DOI: 10.1007/BF01702353Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study identified an interleukin 10-like gene in the genome of equine herpesvirus type 2, thus providing further evidence of IL-10 or IL-10-like gene presence in herpesviruses.

Identification of the IL-10-like gene

  • The research focuses on a gene found in the EcoRI DNA fragment N (4.3 kbp) of equine herpesvirus type 2 (EHV-2).
  • This gene codes for a protein with 179 amino acid residues.
  • The protein is homologous, i.e., similar in sequence, origin, and structure, to the cytokine synthesis inhibitory factor (CSIF), also known as interleukin 10 (IL-10), found in humans and mice.
  • The protein also shows homology to the Epstein-Barr virus (EBV) protein BCRF1.

Significance of the IL-10-like gene in Herpesviruses

  • The discovery of this IL-10-like gene in the genome of the equine herpesvirus type 2 is significant as it is further proof that the herpesviral family of viruses does indeed contain IL-10 or IL-10-like genes.
  • Upon comparing the identified gene to the corresponding genes in other organisms, the researchers argue that these similarities reveal a common ancestry and indicate that the herpesviruses have retained this cytokine-synthesis-inhibitory property.
  • Interleukin 10 is a powerful inhibitor of cytokine synthesis and plays a pivotal role in controlling immune responses. Its presence in the herpesvirus genome might contribute to the ability of herpesviruses to evade the host immune system, persist in the host, and cause chronic infections.

Cite This Article

APA
Rode HJ, Janssen W, Rösen-Wolff A, Bugert JJ, Thein P, Becker Y, Darai G. (1993). The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene. Virus Genes, 7(1), 111-116. https://doi.org/10.1007/BF01702353

Publication

Virus genes
ISSN: 0920-8569
NlmUniqueID: 8803967
Country: United States
Language: English
Volume: 7
Issue: 1
Pages: 111-116

Researcher Affiliations

Rode, H J
  • Institut für Medizinische Virologie, Universität Heidelberg, Germany.
Janssen, W
    Rösen-Wolff, A
      Bugert, J J
        Thein, P
          Becker, Y
            Darai, G

              MeSH Terms

              • Amino Acid Sequence
              • Animals
              • Base Sequence
              • DNA, Viral / genetics
              • Genes, Viral
              • Herpesviridae / genetics
              • Herpesvirus 4, Human / genetics
              • Humans
              • Interleukin-10 / genetics
              • Mice
              • Molecular Sequence Data
              • Sequence Homology, Amino Acid
              • Species Specificity
              • Viral Proteins / genetics

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