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The healing effects of a topical phytogenic ointment on insect bite hypersensitivity lesions in horses.

Abstract: Insect bite hypersensitivity (IBH) is the most common cause of pruritus in horses and is a serious welfare issue for affected animals. In this study, the effect of a topical phytogenic ointment on the healing of cutaneous lesions was investigated in a double-blind trial involving 26 horses with I B H. The number of lesions and their total surface area were recorded on days 0, 7, and 21 in horses treated for 3 weeks with either verum or placebo ointment. After unblinding of treatment assignment, the horses that had been treated with the placebo ointment received the verum preparation for an additional 3 weeks and the number of lesions and their total surface area were again recorded. This part of the study was not blinded. The number of lesions and the total surface area decreased in both treatment groups (no significant difference). Owners also scored the degree of discomfort suffered by their horses as a result of IBH lesions, and at the end of the 3-week period this score was significantly lower in the verum than in the placebo group (P = 0.04). When placebo-treated horses subsequently received the verum ointment, their wound severity score also decreased significantly (P < 0.01). Daily application of an ointment (verum or placebo) does not cure IBH, but use of the phytogenic ointment led to a decrease in the owner-assessed discomfort suffered by horses.
Publication Date: 2011-02-08 PubMed ID: 21294393
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

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The study investigates the effects of a plant-derived topical ointment on healing insect bite hypersensitivity lesions in horses, showing that while the application of any ointment does not cure the hypersensitivity, the plant-based ointment significantly reduces horse discomfort according to owner feedback.

Introduction to Insect Bite Hypersensitivity in Horses

  • This research examines a significant issue in equine health – Insect Bite Hypersensitivity (IBH), the most prevalent reason for itchiness in horses. IBH is highly distressing for the animals, making it an important area for study.

Phytogenic Ointment Trial Design

  • The researchers initiated a double-blind trial. Double-blind means neither the researchers nor the horse owners knew which horses received the plant-based (verum) ointment and which got the placebo.
  • The study included 26 horses, all suffering from IBH. Over 21 days, the number of skin lesions and their total surface area was recorded on the initial day, after a week, and at the end of the trial.
  • After 21 days and, crucially, after revealing which ointment the horses received, horses initially given the placebo were then treated with the phytogenic ointment for another three weeks. The change in number and area of skin lesions was then recorded.

Observations and Findings

  • The researchers found that both the verum and placebo groups saw a decrease in the number of lesions and their total surface area, with no significant difference between the two groups. This suggests the act of regular application itself might contribute to improved skin condition, but it doesn’t treat the underlying hypersensitivity.
  • The most significant finding comes from owner observation. Owners gauged the discomfort level of their horses, and at the end of the three week period, those in the phytogenic ointment group demonstrated a notably lower level of discomfort than those in the placebo group.
  • When the placebo group horses were subsequently treated with the plant-based ointment, owners also observed a significant drop in their discomfort levels. This would suggest that while topical treatment may not eliminate IBH, the plant-based ointment offers substantial relief from discomfort associated with the condition.

Cite This Article

APA
van den Boom R, Kempenaars M, van Oldruitenborgh-Oosterbaan MM. (2011). The healing effects of a topical phytogenic ointment on insect bite hypersensitivity lesions in horses. Tijdschr Diergeneeskd, 136(1), 20-26.

Publication

ISSN: 0040-7453
NlmUniqueID: 0031550
Country: Netherlands
Language: English
Volume: 136
Issue: 1
Pages: 20-26

Researcher Affiliations

van den Boom, R
  • Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University. r.vandenboom@uu.nl
Kempenaars, M
    van Oldruitenborgh-Oosterbaan, M M Sloet

      MeSH Terms

      • Administration, Topical
      • Animals
      • Horse Diseases / drug therapy
      • Horse Diseases / pathology
      • Horses
      • Hypersensitivity / drug therapy
      • Hypersensitivity / pathology
      • Hypersensitivity / veterinary
      • Illicium / chemistry
      • Insect Bites and Stings / drug therapy
      • Insect Bites and Stings / pathology
      • Insect Bites and Stings / veterinary
      • Phytotherapy / veterinary
      • Plant Preparations / administration & dosage
      • Plant Preparations / therapeutic use
      • Pruritus / drug therapy
      • Pruritus / pathology
      • Pruritus / veterinary
      • Severity of Illness Index
      • Treatment Outcome

      Citations

      This article has been cited 1 times.
      1. Schurink A, Wolc A, Ducro BJ, Frankena K, Garrick DJ, Dekkers JC, van Arendonk JA. Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands. Genet Sel Evol 2012 Oct 30;44(1):31.
        doi: 10.1186/1297-9686-44-31pubmed: 23110538google scholar: lookup