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The Journal of pharmacy and pharmacology1975; 27(11); 801-805; doi: 10.1111/j.2042-7158.1975.tb10220.x

The in vitro adsorption of drugs from horse serum onto carbon coated with an acrylic hydrogel.

Abstract: In vitro studies have shown that uncoated carbon and carbon coated with an acrylic hydrogel are capable of adsorbing drugs from horse serum at 37 degrees. Increase in the coating weight from 2 to 4% decreased the rate of adsorption but not the total capacity. In vivo data supports the concept of carbon haemoperfusion for use in the treatment of drug overdose.
Publication Date: 1975-11-01 PubMed ID: 1486DOI: 10.1111/j.2042-7158.1975.tb10220.xGoogle Scholar: Lookup
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Summary

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Research studies conducted in a controlled environment (outside of a living organism, typically in a lab setting – hence “in vitro”) found that two types of carbon materials can capture (or “adsorb”) drugs from horse blood serum when the temperature is maintained at 37 degrees Celsius (which is close to the body temperature of many mammals, including humans).

  1. Uncoated carbon: This is just the pure carbon material without any additional layers on its surface.
  2. Carbon coated with an acrylic hydrogel: This is carbon that has a layer of a specific type of gel (acrylic hydrogel) on its surface.

When the weight of the acrylic hydrogel coating on the carbon was increased from 2% to 4%, the speed at which the carbon could capture drugs from the serum slowed down. However, the overall amount of drugs that the carbon could capture (its total capacity) remained the same.

Research data obtained from studies conducted within living organisms (typically animals or humans – hence “in vivo”) supports the idea of using “carbon haemoperfusion” as a treatment method for drug overdoses. “Carbon haemoperfusion” is a medical procedure where blood is passed through a device containing activated carbon to remove harmful substances (like drugs in case of an overdose) from the bloodstream.

In summary, the research indicates that certain types of carbon can capture drugs from blood, suggesting a potential medical application for treating drug overdoses.

Cite This Article

APA
Kolthammer J. (1975). The in vitro adsorption of drugs from horse serum onto carbon coated with an acrylic hydrogel. J Pharm Pharmacol, 27(11), 801-805. https://doi.org/10.1111/j.2042-7158.1975.tb10220.x

Publication

ISSN: 0022-3573
NlmUniqueID: 0376363
Country: England
Language: English
Volume: 27
Issue: 11
Pages: 801-805

Researcher Affiliations

Kolthammer, J

    MeSH Terms

    • Acrylates
    • Adsorption
    • Animals
    • Carbon
    • Gels
    • Horses
    • In Vitro Techniques
    • Perfusion
    • Pharmaceutical Preparations / blood
    • Poisoning / therapy
    • Rabbits
    • Time Factors

    Citations

    This article has been cited 1 times.
    1. Morgan MD, Rainford DJ, Pusey CD, Robins-Cherry AM, Henry JG. The treatment of quinine poisoning with charcoal haemoperfusion. Postgrad Med J 1983 Jun;59(692):365-7.
      doi: 10.1136/pgmj.59.692.365pubmed: 6634542google scholar: lookup