FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Acta Vet Scand / The interaction of cadmium and selenium in horse kidney cort...
Acta veterinaria Scandinavica1987; 28(2); 201-208; doi: 10.1186/BF03548243

The interaction of cadmium and selenium in horse kidney cortex in relation to histopathological changes.

Abstract: The kidney cortex of 32 Finnish horses was analysed chemically for cadmium (Cd) and selenium (Se) content and by light microscopy for histopathological changes of the tissues. Cd concentrations in kidney cortex ranged from 6.9 to 91.6 mg/kg wet weight with an average of 31.9 mg/kg. Se concentrations ranged from 0.5 to 1.5 mg/kg with an average of 1.0 mg/kg. The age of the horses varied from 1.5 to 32 years; mean age was 16 years. Cd levels in kidney cortex seemed to increase linearly up to an age of about 16 years. In old (over 16 years) horses no such correlation could be found. Se concentrations were found to decrease in relation to age. The horses with higher than 1 mg/kg Se in kidney cortex had less PAS-positive casts than horses with low Se content. Among the total population of the horses no correlation could be demonstrated between Cd and Se concentrations in kidney cortex. However, the horses with more than 40 mg/kg Cd in their kidney cortex had a slightly positive correlation between Cd and Se concentrations. Njurbarken hos 32 finska hästar analyserades med kemiska metoder rörande förekomsten av kadmium (Cd) och selen (Se) och med ljusmikroskopiska metoder rörande histopatologiska förändringar. Cd-koncentrationen i njurbarken varierade från 6.9 till 91.6 mg/kg våtvikt med ett medelvärde av 31.9 mg/kg. Se-koncentrationen varierade från 0.5 till 1.5 mg/kg med et medelvärde av 1.0 mg/kg. Hästarnas ålder varierade från 1.5 till 32 år, genomsnittsåldern var 16 år. Cd-halten föreföll att öka jämnt till 16 års ålder men hos gamla (över 16 år) hästar kunde ingen sådan korrelation påvisas. Se-koncentrationen minskade i relation til åldern. PAS-positiva ackumulationer förekom, lägre grad hos hästarna med hög (över 1 mg/kg) Se-koncentration än hos hästarna med låg Se-halt, I hela hästmaterialet kunde ingen korrelation påvisas mellan koncentrationerna av Cd och Se. Hästarna med mera än 40 mg/kg Cd i njurbarken visade en svag positiv korrelation mellan koncentrationerna av Cd och Se.
Get Full Text
Publication Date: 1987-01-01 PubMed ID: 3447475PubMed Central: PMC8185781DOI: 10.1186/BF03548243Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates the interaction of cadmium and selenium in the horse kidney cortex and how it relates to observable tissue changes. It involved analyzing and comparing the cadmium and selenium concentrations of 32 Finnish horses.

Introduction

This study analyses the interaction of two significant elements, cadmium (Cd) and selenium (Se), in the kidneys of horses. Cadmium, a heavy metal, and selenium, a trace element, are both essential to the research as variations in their concentration levels can indicate potential health risks or disorders in horses.

Sample and Methodology

  • The researchers gathered 32 Finnish horses to conduct their study.
  • These horses ranged from 1.5 to 32 years old, with the mean age being 16 years.
  • The researchers chemically analyzed the kidney cortex of these horses for cadmium and selenium content.
  • Additionally, they used light microscopy to observe histopathological changes, which entail observable alterations to the tissue’s microscopic structure.

Findings: Cadmium Concentration and Age Correlation

  • The cadmium concentrations in the horses’ kidney cortices ranged from 6.9 to 91.6 mg/kg wet weight, averaging at 31.9 mg/kg.
  • Results varied but generally showed a linear increase in cadmium levels in the kidney cortex up to an age of approximately 16 years.
  • In older horses (over 16 years), a correlation between cadmium levels and age was not observed.

Findings: Selenium Concentration and Age Correlation

  • For selenium, concentrations spanned from 0.5 to 1.5 mg/kg, with an average of 1.0 mg/kg.
  • Unlike cadmium, however, selenium concentrations were found to decrease as the horses aged.
  • Horses with higher selenium concentrations in their kidney cortex (more than 1 mg/kg) had less PAS-positive casts, an indication of lowered kidney function, compared to those with low selenium content.

Findings: Correlation Between Cadmium and Selenium Concentrations

  • There was no observable correlation between cadmium and selenium concentrations for the entire population of horses examined.
  • However, in horses with more than 40 mg/kg of cadmium in their kidney cortex, a slightly positive correlation was noticed between cadmium and selenium concentrations.

Cite This Article

APA
Junnila M, Korkeala H, Rahko T, Salmi A. (1987). The interaction of cadmium and selenium in horse kidney cortex in relation to histopathological changes. Acta Vet Scand, 28(2), 201-208. https://doi.org/10.1186/BF03548243

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 28
Issue: 2
Pages: 201-208

Researcher Affiliations

Junnila, M
    Korkeala, H
      Rahko, T
        Salmi, A

          MeSH Terms

          • Aging
          • Animals
          • Cadmium / analysis
          • Horses / metabolism
          • Kidney Cortex / analysis
          • Kidney Cortex / pathology
          • Selenium / analysis

          References

          This article includes 19 references
          1. Bjorland J, Norheim G. Renal cadmium and zinc concentrations in horses in Norway.. Nord Vet Med 1981 Dec;33(12):530-4.
            pubmed: 7335486
          2. Bozkurt A, Smith J. The interaction between cadmium and selenium in the rat. 1981;pp. 530–534.
          3. Chavez E. Dietary selenium and cadmium interrelationships in weanling pigs. Can. J. Anim. Sei. 1981;67:713–718.
            doi: 10.4141/cjas81-086google scholar: lookup
          4. Chen RW, Whanger PD, Weswig PH. Selenium - induced redistribution of cadmium binding to tissue proteins: a possible mechanism of protection against cadmium toxicity.. Bioinorg Chem 1975 Jan;4(2):125-33.
            pubmed: 164958doi: 10.1016/s0006-3061(00)81021-2google scholar: lookup
          5. Elinder CG, Jönsson L, Piscator M, Rahnster B. Histopathological changes in relation to cadmium concentration in horse kidneys.. Environ Res 1981 Oct;26(1):1-21.
            doi: 10.1016/0013-9351(81)90179-1pubmed: 7297523google scholar: lookup
          6. Flegal KM, Cary EE, Pond WG, Krook LP. Dietary selenium and cadmium interrelationships in growing swine.. J Nutr 1980 Jun;110(6):1255-61.
            doi: 10.1093/jn/110.6.1255pubmed: 7381592google scholar: lookup
          7. Flora SJ, Behari JR, Ashquin M, Tandon SK. Time-dependent protective effect of selenium against cadmium-induced nephrotoxicity and hepatotoxicity.. Chem Biol Interact 1982 Dec;42(3):345-51.
            doi: 10.1016/0009-2797(82)90078-3pubmed: 7151236google scholar: lookup
          8. Friberg L, Piscator M, Nordberg G, Kjellström T. Cadmium in the Environment. 2nd. Cleveland: CRC Press Inc.; 1974.
          9. Gasiewicz TA, Smith JC. Interaction between cadmium and selenium in rat plasma.. Environ Health Perspect 1978 Aug;25:133-6.
            doi: 10.1289/ehp.7825133pmc: PMC1637195pubmed: 720299google scholar: lookup
          10. GUNN SA, GOULD TC. Selective accumulation of Cd115 by cortex of rat kidney.. Proc Soc Exp Biol Med 1957 Dec;96(3):820-3.
            doi: 10.3181/00379727-96-23619pubmed: 13505870google scholar: lookup
          11. Koljonen T. The behavior of selenium in Finnish soils. Ann. Agr. Fenn. 1975;14:240–247.
          12. Kägi J, Vallee B. Metallothionein: a cadmium and zinecontaining protein from equine renal cortex. J. biol. Chem. 1960, 235, 3460–3465.
          13. Mahaffey KR, Capar SG, Gladen BC, Fowler BA. Concurrent exposure to lead, cadmium, and arsenic. Effects on toxicity and tissue metal concentrations in the rat.. J Lab Clin Med 1981 Oct;98(4):463-81.
            pubmed: 7288264
          14. Mustonen S, Mellin I. Survo 76 program descriptions. 2nd. Helsinki: Department of Statistics, University of Helsinki; 1982.
          15. Nielson KB, Winge DR. Independence of the domains of metallothionein in metal binding.. J Biol Chem 1985 Jul 25;260(15):8698-701.
            pubmed: 4019449
          16. Piotrowski JK, Bem EM, Werner A. Cadmium and mercury binding to metallothionein as influenced by selenium.. Biochem Pharmacol 1977 Nov 15;26(22):2191-2.
            doi: 10.1016/0006-2952(77)90274-Xpubmed: 588303google scholar: lookup
          17. Stabei-Taucher R. Determination of selenium in biological material. Finn. Chem. Lett. 1977;pp. 57–60.
          18. Stabei-Taucher R, Nurmi E, Karppanen E. Content of copper, zinc, lead, cadmium and mercury in muscle, liver and kidney of Finnish cattle. J. Sci. Agr. Soc. Finland. 1975;47:469–479.
          19. Teilmann AM, Hansen JC. Cadmium and selenium levels in kidneys from Danish horses.. Nord Vet Med 1984 Jan-Feb;36(1-2):49-56.
            pubmed: 6728673

          Citations

          This article has been cited 1 times.
          1. Paßlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Neumann K, Zentek J. Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in the equine liver and kidneys. Springerplus 2014;3:343.
            doi: 10.1186/2193-1801-3-343pubmed: 25061551google scholar: lookup
          Subscribe to our newsletter
          Join 99,001 horse owners like you who receive our email updates on horse health and nutrition.