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Animal genetics2011; 43(4); 450-453; doi: 10.1111/j.1365-2052.2011.02277.x

The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses.

Abstract: Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R was previously detected in one of the two Swiss Warmblood families. We sequenced the entire IL4R gene in this family and detected 93 variants including five non-synonymous protein-coding variants. The allele distribution at these SNPs supported the previously detected QTL signal. Subsequently, we investigated IL4R mRNA expression in bronchoalveolar lavage fluid cells. During exacerbation, IL4R expression was increased in RAO-affected offspring in the implicated family, but not in the other family. These findings support that IL4R plays a role in some cases of RAO.
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
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Publication Date: 2011-10-28 PubMed ID: 22497430DOI: 10.1111/j.1365-2052.2011.02277.xGoogle Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focused on the involvement of the interleukin-4 receptor gene in recurrent airway obstruction in Swiss Warmblood horses, a condition similar to human asthma. It identified genetic variations in the gene that could be linked to the condition and provided evidence of increased gene expression during disease exacerbation.

Genetic and Environmental Factors in Recurrent Airway Obstruction

  • The research focused on recurrent airway obstruction (RAO), a condition found in horses that shares many similarities with human asthma.
  • The cause of this disease is a combination of both genetic and environmental factors, necessitating a multi-faceted approach to its study and understanding.

Role of the Interleukin-4 Receptor Gene

  • The interleukin-4 receptor gene (IL4R) is believed to be involved in RAO.
  • Previous studies have suggested a correlation between IL4R and RAO, with the gene being located in a QTL region on chromosome 13. This region was discovered in one of two Swiss Warmblood families under investigation.
  • The current study deepened this investigation by sequencing the entire IL4R gene within this family and found 93 variations, with five being non-synonymous protein-coding variants.
  • The distribution of alleles at these Single nucleotide polymorphisms (SNPs), supported the initially detected QTL signal, implying a genetic link to RAO.

Increased Gene Expression during Exacerbation

  • The researchers didn’t just stop at genetic variation, they also looked into gene expression during disease exacerbation.
  • Using bronchoalveolar lavage fluid cells, they found that IL4R gene expression was increased in the members of the family initially tested, but not in the other unaffected family during an RAO exacerbation.
  • This increased gene expression further supports the idea that the IL4R gene may play a significant role in some cases of RAO.

The findings from this study highlight IL4R’s role in RAO and provide direction for future research to elucidate the genetic underpinnings of this disease in horses. This information could be crucial in devising new treatments and better management strategies for RAO.

Cite This Article

APA
Klukowska-Rötzler J, Swinburne JE, Drögemüller C, Dolf G, Janda J, Leeb T, Gerber V. (2011). The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses. Anim Genet, 43(4), 450-453. https://doi.org/10.1111/j.1365-2052.2011.02277.x

Publication

Animal genetics
ISSN: 1365-2052
NlmUniqueID: 8605704
Country: England
Language: English
Volume: 43
Issue: 4
Pages: 450-453

Researcher Affiliations

Klukowska-Rötzler, J
  • Institute of Genetics, Vetsuisse Faculty, University of Bern, Switzerland. jolanta.klukowska@vetsuisse.unibe.ch
Swinburne, J E
    Drögemüller, C
      Dolf, G
        Janda, J
          Leeb, T
            Gerber, V

              MeSH Terms

              • Airway Obstruction / physiopathology
              • Airway Obstruction / prevention & control
              • Airway Obstruction / veterinary
              • Alleles
              • Animals
              • Bronchoalveolar Lavage Fluid / cytology
              • Case-Control Studies
              • Environment
              • Horse Diseases / physiopathology
              • Horse Diseases / prevention & control
              • Horses / classification
              • Horses / genetics
              • Quantitative Trait Loci
              • RNA, Messenger / genetics
              • RNA, Messenger / metabolism
              • Receptors, Interleukin-4 / genetics
              • Receptors, Interleukin-4 / metabolism
              • Recurrence

              Citations

              This article has been cited 13 times.
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                doi: 10.3390/ani13182928pubmed: 37760328google scholar: lookup
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