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Clinics in chest medicine2005; 26(3); 459-vi; doi: 10.1016/j.ccm.2005.05.003

The lung at maximal exercise: insights from comparative physiology.

Abstract: Horses are bred selectively for aerobic performance and have extraordinarily high maximal oxygen consumption, approximately double the mass-specific value for human athletes. Pulmonary limitations to exercise performance are well described in these animals, including exercise-induced arterial hypoxemia and exercise-induced pulmonary hemorrhage. In human athletes, pulmonary limitations are recognized increasingly as affecting athletic performance. Potential pulmonary limitations during maximal exercise are compared in human and equine athletes.
Publication Date: 2005-09-06 PubMed ID: 16140138DOI: 10.1016/j.ccm.2005.05.003Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • N.I.H.
  • Extramural
  • Research Support
  • U.S. Gov't
  • P.H.S.
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on understanding the limitations of pulmonary function during maximum exercise, by comparing human athletes with horses, known for their exceptional aerobic capabilities.

Comparison of Human and Equine Athletes

The main objective of the research was to compare pulmonary limitations during maximal exercise in human athletes and equine athletes, particularly horses, due to their designation for extraordinary aerobic performance.

  • Researchers observed that horses have a maximal oxygen consumption rate nearly double that of human athletes. This higher rate is a result of selective breeding in horses to improve aerobic performance.
  • In spite of higher maximal oxygen consumption, horses exhibit pulmonary limitations during peak performance. These limitations include exercise-induced arterial hypoxemia and exercise-induced pulmonary hemorrhage.

Pulmonary Limitations in Athletes

The study also aimed to shed light on the impact of potential pulmonary limitations on athletic performance in humans.

  • It noted that there is increasing recognition of such pulmonary limitations in human athletes as well.
  • These limitations can affect the athletes’ performance during maximal exercise, similar to the pulmonary issues seen in horses.

Insights from Comparative Physiology

Through the comparison of horses and human athletes, this study brings important insights regarding the impact of exercise to the maximum on lung function and aerobic performance.

  • It suggests that even though horses are bred for greater aerobic performance, there are certain pulmonary limitations that prevent them from reaching their full potential during maximal exercise.
  • These findings could have significant implications for human athletes, providing a better understanding of how maximal exercise can impose limitations on pulmonary function, and how to overcome or manage these potential disruptions.

Cite This Article

APA
Hopkins SR. (2005). The lung at maximal exercise: insights from comparative physiology. Clin Chest Med, 26(3), 459-vi. https://doi.org/10.1016/j.ccm.2005.05.003

Publication

ISSN: 0272-5231
NlmUniqueID: 7907612
Country: United States
Language: English
Volume: 26
Issue: 3
Pages: 459-vi

Researcher Affiliations

Hopkins, Susan R
  • Division of Physiology, Department of Medicine, University of California--San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. shopkins@ucsd.edu

MeSH Terms

  • Exercise / physiology
  • Humans
  • Lung / physiology
  • Lung / physiopathology
  • Respiratory Physiological Phenomena

Grant Funding

  • HL-17731 / NHLBI NIH HHS

Citations

This article has been cited 3 times.
  1. Miserocchi G. The impact of heterogeneity of the air-blood barrier on control of lung extravascular water and alveolar gas exchange.. Front Netw Physiol 2023;3:1142245.
    doi: 10.3389/fnetp.2023.1142245pubmed: 37251706google scholar: lookup
  2. Miserocchi G, Beretta E. A century of exercise physiology: lung fluid balance during and following exercise.. Eur J Appl Physiol 2023 Jan;123(1):1-24.
    doi: 10.1007/s00421-022-05066-3pubmed: 36264327google scholar: lookup
  3. Capomaccio S, Cappelli K, Spinsanti G, Mencarelli M, Muscettola M, Felicetti M, Verini Supplizi A, Bonifazi M. Athletic humans and horses: comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest.. BMC Physiol 2011 Jan 21;11:3.
    doi: 10.1186/1472-6793-11-3pubmed: 21255427google scholar: lookup