The molecular basis of Streptococcus equi infection and disease.
Abstract: Streptococcus equi is the aetiological agent of strangles, one of the most prevalent diseases of the horse. The animal suffering and economic burden associated with this disease necessitate effective treatment. Current antibiotic therapy is often ineffective and thus recent attention has focused on vaccine development. A systematic understanding of S. equi virulence, leading to the identification of targets to which protective immunity can be directed, is a prerequisite of the development of such a vaccine. Here, the virulence factors of S. equi are reviewed.
Publication Date: 2002-04-05 PubMed ID: 11932201DOI: 10.1016/s1286-4579(02)01565-4Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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The research article focuses on understanding the molecular basis of the Streptococcus equi infection, a major horse disease called strangles, with the objective of identifying targets for vaccine development as the current antibiotic treatment is often ineffective.
Introduction to Streptococcus equi and Strangles
- Streptococcus equi is a pathogenic bacterium that causes strangles, a severe infection in horses.
- Strangles is a highly prevalent disease among horses, causing significant suffering and economic burden given the ineffective current treatment modalities.
- The treatment primarily involves antibiotic therapy, which often falls short in treating the disease effectively.
Focusing on Vaccine Development
- The research revolves around the development of vaccines to combat this infection as antibiotic treatments have proven to be inadequate.
- The focus is not solely on developing a vaccine but also comprehending the virulence, i.e., the degree of pathogenicity within a group or species of parasites as manifested by severe clinical signs of disease.
Understanding S. equi Virulence
- Understanding the S. equi virulence is a paramount prerequisite for the development of a working vaccine.
- This involves a systematic understanding and analysis of the S. equi virulence to identify targets where protective immunity can be directed, which would ultimately help in developing a vaccine.
- The research paper therefore provides a review of the virulence factors of S. equi to help facilitate the development of an effective vaccine.
Cite This Article
APA
Harrington DJ, Sutcliffe IC, Chanter N.
(2002).
The molecular basis of Streptococcus equi infection and disease.
Microbes Infect, 4(4), 501-510.
https://doi.org/10.1016/s1286-4579(02)01565-4 Publication
Researcher Affiliations
- Department of Biomedical Sciences, University of Bradford, West Yorkshire, BD7 1DP, UK. d.harrington@bradford.ac.uk
MeSH Terms
- Animals
- Bacterial Adhesion
- Bacterial Proteins / chemistry
- Bacterial Proteins / genetics
- Bacterial Proteins / metabolism
- Carrier Proteins / chemistry
- Carrier Proteins / genetics
- Carrier Proteins / metabolism
- Horse Diseases / microbiology
- Horses / microbiology
- Streptococcal Infections / microbiology
- Streptococcal Infections / veterinary
- Streptococcal Vaccines / chemistry
- Streptococcal Vaccines / immunology
- Streptococcus equi / enzymology
- Streptococcus equi / genetics
- Streptococcus equi / pathogenicity
- Streptococcus equi / physiology
- Virulence
Citations
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