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Veterinary and comparative oncology2020; 19(1); 7-16; doi: 10.1111/vco.12659

The oncogenic pathways of papillomaviruses.

Abstract: Papillomaviruses are oncogenic DNA viruses and induce hyperplastic benign lesions of both cutaneous and mucosal tissues in their various hosts, including many domestic and wild animals as well as humans. There are some Papillomavirus genotypes that can infect hosts different from their own, such as BPV 1 and BPV 2 originated from cattle, which can also infect horses and are responsible for fibroblastic tumours in horses. This review article summarizes the origin and evolution of papillomaviruses as an etiological agent in the historical process. The main focus in this review is the evaluation of the interactions between high-risk papillomavirus oncoproteins and programmed cell-death pathways. It further exemplifies the role of these interactions in the malignant cell transformation process. In parallel with this, the use and importance of the bovine model system to enlighten the papillomavirus-associated cancers is discussed with an in-depth examination. Furthermore, it focuses on the epidemiological situation of BPV infections in Turkey in the cattle herds.
© 2020 John Wiley & Sons Ltd.
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Publication Date: 2020-11-02 PubMed ID: 33084187DOI: 10.1111/vco.12659Google Scholar: Lookup
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Summary

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This research article abstract delves into the oncogenic pathways of Papillomaviruses, and explores the interactions between high-risk papillomavirus oncoproteins and cell death pathways that facilitate malignant cell transformations. The use of bovine models to understand these processes and the epidemiological situation in Turkey are also discussed.

Understanding Papillomaviruses Origins and Evolution

  • The central premise of the article reviews the evolution and the historical role of papillomaviruses as agents that cause diseases. These are oncogenic DNA viruses known for inducing hyperplastic benign lesions in both cutaneous and mucosal tissues across various hosts, including domestic and wild animals, and humans as well.
  • Notably, some Papillomavirus genotypes, such as BPV 1 and BPV 2, can infect hosts different from their natural ones. Originated in cattle, these types can infect horses and are responsible for fibroblastic tumours in them.

Papillomavirus Oncoproteins and Their Interactions with Cell-Death Pathways

  • The research focuses on evaluating the interactions between high-risk papillomavirus oncoproteins and programmed cell-death pathways. These interactions typically play a central role in the transformation process of malignant cells.

The Bovine Model System in Understanding Papillomavirus-Associated Cancers

  • The article discusses the use and importance of the bovine model system to help provide deeper insights into the cancers associated with papillomavirus. Such models meticulously recreate the conditions of the disease and can help in understanding the nature, spread, and potential treatment alternatives for the condition.

Epidemiological Situation of BPV Infections in Turkey

  • Moreover, the study includes an analysis of the epidemiological situation of BPV infections in Turkey, focusing on cattle herds. It presents a discussion that concerns the patterns, causes, and effects of these infections within this specific region. This in-depth study could provide valuable information for the development of preventive measures to control the spread of BPV infections.

Cite This Article

APA
Kaynarcalidan O, Oğuzoğlu TÇ. (2020). The oncogenic pathways of papillomaviruses. Vet Comp Oncol, 19(1), 7-16. https://doi.org/10.1111/vco.12659

Publication

Veterinary and comparative oncology
ISSN: 1476-5829
NlmUniqueID: 101185242
Country: England
Language: English
Volume: 19
Issue: 1
Pages: 7-16

Researcher Affiliations

Kaynarcalidan, Onur
  • Institute for Virology Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Oğuzoğlu, Tuba Çiğdem
  • Department of Virology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.

MeSH Terms

  • Animals
  • Carcinogenesis
  • Cell Differentiation
  • Gene Expression Regulation, Viral
  • Genome, Viral
  • Humans
  • Papillomaviridae / genetics
  • Papillomaviridae / physiology
  • Papillomavirus Infections / veterinary
  • Papillomavirus Infections / virology

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Citations

This article has been cited 8 times.
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