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Home / Equine Research Bank / Adv Drug Deliv Rev / The past, present and future in scaffold-based tendon treatm...
Advanced drug delivery reviews2014; 84; 257-277; doi: 10.1016/j.addr.2014.11.022

The past, present and future in scaffold-based tendon treatments.

Abstract: Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.
Copyright © 2014 Elsevier B.V. All rights reserved.
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Publication Date: 2014-12-10 PubMed ID: 25499820DOI: 10.1016/j.addr.2014.11.022Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the development and potential of scaffold-based therapies for tendon injuries. The report critically analyzes the established treatments and promising technologies that aim to remodel tendon treatments in the future.

Overview of Tendon Injuries

  • Tendon injuries pose a substantial clinical burden on healthcare systems around the globe.
  • As the human lifespan extends and the population grows older, these types of injuries are expected to become more widespread, particularly among the younger generation with a considerable span of life ahead of them.

Scaffold-Based Intervention Strategies

  • Developments in the fields of engineering, chemistry, and biology have resulted in a wide range of three-dimensional scaffold-based treatment approaches. These scaffolds can be either naturally derived or synthetically made.
  • The use of these scaffolds in tendon injury repair provides a structural framework that supports tissue regeneration.

Functionalisation Strategies of Scaffolds

  • The article also delves into the functionalisation strategies of scaffolds based on biophysical, biochemical, and biological cues.
  • These strategies provide control over cell functions, allowing for the targeted and sustained release of therapeutics or biologics.
  • Notably, these functionally designed scaffolds have the capability to positively interact with the host (the patient’s body), that drives the repair and regrowth of tendons.

Therapies and Emerging Technologies

  • The authors offer a critical discussion on present therapies for tendon injuries and forthcoming technologies that can fundamentally alter tendon treatments in the future.
  • They take a keen interest in analyzing the strengths and weaknesses of current treatments and speculate on how cutting-edge technologies could potentially overcome these limitations.

Cite This Article

APA
Lomas AJ, Ryan CN, Sorushanova A, Shologu N, Sideri AI, Tsioli V, Fthenakis GC, Tzora A, Skoufos I, Quinlan LR, O'Laighin G, Mullen AM, Kelly JL, Kearns S, Biggs M, Pandit A, Zeugolis DI. (2014). The past, present and future in scaffold-based tendon treatments. Adv Drug Deliv Rev, 84, 257-277. https://doi.org/10.1016/j.addr.2014.11.022

Publication

Advanced drug delivery reviews
ISSN: 1872-8294
NlmUniqueID: 8710523
Country: Netherlands
Language: English
Volume: 84
Pages: 257-277
PII: S0169-409X(14)00295-6

Researcher Affiliations

Lomas, A J
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Ryan, C N M
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Sorushanova, A
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Shologu, N
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Sideri, A I
  • Veterinary Faculty, University of Thessaly, Karditsa, Greece.
Tsioli, V
  • Veterinary Faculty, University of Thessaly, Karditsa, Greece.
Fthenakis, G C
  • Veterinary Faculty, University of Thessaly, Karditsa, Greece.
Tzora, A
  • Animal Production Division, Department of Agriculture Technology, TEI of Epirus, Arta, Greece.
Skoufos, I
  • Animal Production Division, Department of Agriculture Technology, TEI of Epirus, Arta, Greece.
Quinlan, L R
  • Department of Physiology, NUI Galway, Ireland.
O'Laighin, G
  • College of Engineering and Informatics, NUI Galway, Galway, Ireland.
Mullen, A M
  • Teagasc Research Centre, Ashtown, Ireland.
Kelly, J L
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; Department of Surgery, NUI Galway, Galway, Ireland.
Kearns, S
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; University College Hospitals Galway (UCHG), Galway, Ireland.
Biggs, M
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Pandit, A
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Zeugolis, D I
  • Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland. Electronic address: dimitrios.zeugolis@nuigalway.ie.

MeSH Terms

  • Humans
  • Regeneration / physiology
  • Tendons / physiology
  • Tissue Scaffolds / trends

Citations

This article has been cited 52 times.
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